Rchr

J-GLOBAL ID：200901052008634856 Update date: Mar. 23, 2026

Hibi Hideharu

ヒビヒデハル | Hibi Hideharu

Affiliation and department：
Job title： Professor

Research field (3)： Other , Other , Surgical dentistry

Research keywords (7)： implantology , prosthodontology , occlusion , orthognathic surgery , distraction osteogenesis , tissue engineering , regenerative medicine

Research theme for competitive and other funds (32)：

2025 - 2028 骨-神経間クロストーク解明による新規顎骨再生治療の開発
2021 - 2024 幹/前駆細胞のシーケンシャルな体内移動を基軸とした新しい骨再生治療の開発
2019 - 2024 Cascaded bone regeneration method with extracellular vesicles prepared for different purposes under variable culture environment
2018 - 2022 自家骨採取量の削減を可能にする生体吸収性アドヒーシブゲルの臨床応用
2019 - 2020 細胞治療の実現化に向けたアドヒーシブ・スキャホールドの開発

2017 - 2020 Evaluation and clinical development of the bone regenerative therapy using bone marrow mesenchymal cells

2016 - 2019 Bone Regeneration with various factors derived from cells in severe culture conditions

2015 - 2018 金属インプラントの生体活性を司る表面階層構造の厳密な構築とin vivo評価

2014 - 2017 腫瘍切除等顎骨欠損症例に対し,予後QOL向上に向けた顎骨再生医療法の最適化研究

2014 - 2017 組織再生スケールアップを目指した生体内血管網構築法の開発

2013 - 2017 工学的・生物学的表面処理の融合によるバイオインプラント製造プロセスの構築と評価

2014 - 2016 硬組織と軟組織のいずれにも適合する金属・セラミックス・有機系生体材料の開発

2013 - 2016 Extended Bone Regeneration Following Distraction Osteogenesis without Device

2013 - 2014 抗炎症性/組織再生型M2マクロファージを誘導する新規タンパク複合体による骨再生研究

2011 - 2014 Cell destruction and reloading treatment for bone graft in oral cancer surgery

2011 - 2013 Analysis of molecular forces for stem/progenitor cell homing in bone regeneration

2010 - 2013 Bone Regeneration following Activated Vascular Network

2009 - 2011 Characterization of dental pulp stem cells and paradigm shift to multifaceted regenerative therapy

2009 - 2011 Induce Cells Activity on in vivo Real-time Monitoring System

2007 - 2009 Periodontal Regeneration on Root Surface

2007 - 2009 Tooth Dock

2006 - 2009 Mandibular Reconstruction Using Distraction Osteogenesis Accelerated with Tissue Engineering

2008 - 2008 SHED Bank

2007 - 2008 Clinical Application of Injectable bone Material

2006 - 2007 Seminar on Regenerative Medicine

2006 - 2007 Clinical Trials of Injectable Bone Mateiral

2004 - 2007 Multicenter Study on Periodontal Regeneration Using Stem Cells

2006 - 2006 Injectable Bone Materials

2004 - 2006 Internal Multidirectional Distraction Device

2004 - 2005 Osteogenic Materials

2003 - 2005 Promoted Distraction Osteogenesis Using Injectable Tissue Engineered Osteogenic Cells

1995 - 1996 Accelerated Osseointegration Using Electrical Stimulation

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Papers (272)：

Kobayashia T., Seo W., Ichimura N., Urata Y., Hibi H., Nishikawa H. Reticulocalbin1-mediated regulation of calcium homeostasis in naïve T lymphoncytes. Cell Calcium. 2026. 134. 103121
Sakai K., Yamaguchi S., Usui S., Yamamoto N., Hibi H. Bilateral pleural effusion and right chylothorax after left cervical dissection: A case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2026. 38. 1. 65-68
Bian H., Fujio M., Matsushita M., Esaki R., Tsuboi M., Wakasugi M., Liu Y., Imagama S., Hibi H. FGFR3 gain-of-function delays intramembranous bone healing in a mouse calvarial fracture model. Biochemical and Biophysical Research Communications. 2025. 788. 152799
Ohara G., Okabe K., Sato K., Toyama N., Ohta Y., Kaminogo K., Watanabe J., Ichimura N., Sakai K., Hibi H. Human dental pulp stem cells-derived small extracellular vesicles prevent osteoradionecrosis of the jaw in a rat model. Nagoya Journal of Medical Science. 2025. 87. 4. 787-800
Tsuboi M., Fujio M., Chang Q., Bian H., Wakasugi M., Liu Y., Hibi H. Rho-associated coiled-coil-containing protein kinase inhibitor Y-27632 promotes distraction osteogenesis healing by activating both osteoblasts and osteoclasts. Nagoya Journal of Medical Science. 2025. 87. 4. 719-729

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MISC (210)：

佐藤康太郎, 日比英晴, 日比英晴. Esthetic restoration of the maxillary right central incisor after fenestration using an obturator: a case report. 日本補綴歯科学会誌(Web). 2024. 16
松本由梨子, 佐藤康太郎, 坪井亮仁, 金子順哉, 日比英晴, 日比英晴. 開窓が奏効した埋伏過剰歯を伴う含歯性嚢胞の1例. 日本口腔科学会雑誌(Web). 2024. 73. 4
岡本昌典, 中島宏彰, 酒井陽, 竹上靖彦, 大澤郁介, 渡邊純奈, 日比英晴, 今釜史郎. 阻血性骨壊死における細胞老化の関与と間葉系幹細胞培養上清液の骨圧壊抑制効果の検討. 日本整形外科学会雑誌. 2023. 97. 8
佐藤康太郎, 坪井亮仁, 日比英晴. Distraction osteogenesis and dental implants after resection of mandible. 日本補綴歯科学会誌(Web). 2023. 15
小原豪, 岡部一登, 外山直人, 外山直人, 太田優也, 渡邊純奈, 佐藤康太郎, 日比英晴, 日比英晴. ヒト歯髄幹細胞由来細胞外小胞は放射線性顎骨壊死の発症を予防する. 日本口腔科学会雑誌(Web). 2023. 72. 4

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Patents (4)：

医薬組成物および併用薬
骨再生用自己組織化ペプチドハイドロゲル
callus elongating/regenerating device
Callus elongating/regenerating device

Books (36)：

Academic Terms of Oral Implantology 2024
Ishiyaku Pub, Inc. 2024 ISBN:9784263456835
標準口腔外科学第5版・口腔に症状を現す血液疾患および止血機構の障害
医学書院 2024 ISBN:9784260053747
標準口腔外科学第5版・口腔・顎顔面疾患の手術とその他の治療
医学書院 2024 ISBN:9784260053747
口腔外科研修ハンドブック
医歯薬出版株式会社 2022 ISBN:9784263458914
Stem Cells and Tissue Repair. Methods in Molecular Biology
Humana 2020 ISBN:9781071606544

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Lectures and oral presentations (572)：

A case of ameloblastoma recurring from soft tissue
(29th Annual Meeting of the Japanese Academy of Maxillofacial Implants 2025)
両側性唇顎口蓋裂を合併した上顎する経鼻的内視鏡腐骨除去手術施行症例
(第70回日本口腔外科学会 2025)
硬膜マクロファージのシグナルと疼痛との関連
(第70回日本口腔外科学会 2025)
低用量ピル休薬とドライソケット:多機関共同研究
(第70回日本口腔外科学会 2025)
Risks of Osteonecrosis of the Jaw to Consider with Irradiation Therapy and Non-Resorbable Bone Substitutes
(55th Annual Meeting, Japanese Society of Oral Implantology 2025)

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Education (2)：

1987 - 1991 Tokyo Medical and Dental University Graduate School, Division of Dental Research Prosthodontology
1981 - 1987 Tokyo Medical and Dental University Faculty of Dentistry

Professional career (1)：

Doctor of Philosophy (Tokyo Medical and Dental University)

Work history (27)：

2025/04 - 現在 Nagoya University Head
2019/04 - 現在 Nagoya University Center for Low-temperature Plasma Sciences (cLPS)
2015/08/01 - 現在 Chief of Department of Oral and Maxillofacial Surgery, Nagoya University Hospital
2015/08 - 現在 Nagoya University Nagoya University Hospital Chief
2015/08 - 現在 Chief of Department of Oral and Maxillofacial Surgery, Nagoya University Hospital Nagoya University Hospital Chief

2015/08/01 - 現在 Professor, Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine Graduate School of Medicine Program in Integrated Medicine Head and Neck and Sensory Organ Medicine Professor

2025/04 - 2025/07 Gifu University Professor

2024/04 - 2024/09 Gifu University Professor

2023/04 - 2023/09 Gifu University Professor

2014/10 - 2015/07 Chief of Department of Oral and Maxillofacial Surgery, Nagoya University Hospital

2014/10 - 2015/07 Nagoya University Nagoya University Hospital

2009/01 - 2015/07 Associate Professor, Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine Program in Cellular Information Medicine Associate professor

2014/01 - 2014/09 Vice-chief of Department of Oral and Maxillofacial Surgery, Nagoya University Hospital

2014/01 - 2014/09 Nagoya University Nagoya University Hospital

2009/04 - 2014/03 Nagoya University Nagoya University Hospital Oral and Maxillofacial Surgery

2012/06 - 2012/08 Gest researcher, University of Freiburg / Researcher exchange program between JSPS and DAAD

2007/04/01 - 2008/12/31 Associate Professor, Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine

2007/04/01 - 2008/12/31 Nagoya University Nagoya University Hospital Center for Genetic and Regenerative Medicine Project Associate professor

2007/04 - 2008/12 Associate Professor, Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine

2004/06/01 - 2007/03/31 Associate Professor, Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine

2004/06/01 - 2007/03/31 Nagoya University Nagoya University Hospital Center for Genetic and Regenerative Medicine Project Assistant Professor

2004/06 - 2007/03 Associate Professor, Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine

2002/08 - 2004/05 Assistant Professor, Department of Protective Care for Masticatory Disorders, Nagoya University Graduate School of Medicine

1995/06 - 2002/07 Part-time Lecturer, Nagoya University School of Medicine

1995/04 - 2002/07 Chief, Department of Oral Surgery and Dentistry, Holy Spirit Hospital

1992/04 - 1995/03 Staff, Department of Oral and Maxillofacial Surgery, Nagoya University Hospital

1991/04 - 1992/03 Staff, Clinic for Prosthetics, Dental Hospital, Tokyo Medical and Dental University

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Committee career (48)：

2023/05 - 現在全国医学部附属病院歯科口腔外科科長会議理事
2022/04 - 現在日本口腔外科学会ダイバーシティ推進委員会委員長
2022/04 - 現在日本口腔外科学会認定医専門医資格認定審査会委員
2021/01 - 現在日本口腔外科学会利益相反管理委員会副委員長
2021/01 - 現在日本口腔外科学会医療安全委員会委員長

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Awards (27)：

2025/01 - Gordon Research Conferences 1st place poster award Generation of novel circular mRNA using a G-quadruplex
2021/11 - Korean Association of Maxillofacial Plastic and Reconstructive Surgeons Excellence prize Comparison of biomechanical analysis after Le Fort I osteotomy with two square-shaped and four L-shaped titanium plates using 3D-FEA
2020/11 - Japanese Society of Oral and Maxillofacial Surgeons Best Research Article Prize (co-presenter)
2018/11 - Japanese Society of Oral and Maxillofacial Surgeons Gold Ribbon Prize (co-presenter)
2018/11 - Japanese Society of Oral and Maxillofacial Surgeons Best Research Article Prize (co-presenter)

2018/09 - 歯科基礎医学会歯科基礎医学会モリタ優秀発表賞(共同)

2017/10 - Japanese Society of Oral and Maxillofacial Surgeons Best Oral Presentation Prize (co-presenter)

2017/07 - 日本顎関節学会日本顎関節学会学術奨励賞(共同) 顎関節症に対する運動療法の短期的効果

2016/09 - 日本学術振興会審査員表彰

2016/08 - 歯科基礎医学会歯科基礎医学会モリタ優秀発表賞(共同)

2016/06 - 日本炎症・再生医学会日本炎症・再生医学会優秀演題賞(共同)

2016/01 - Japanese Society of Oral Oncology Best Poster Presentation Prize (co-presenter)

2014/10 - Japanese Society of Oral and Maxillofacial Surgeons Best Research Article Prize (co-presenter)

2014/10 - Japanese Society of Oral and Maxillofacial Surgeons Best Oral Presentation Prize (co-presenter)

2014/10 - Japanese Society of Oral and Maxillofacial Surgeons Gold Ribbon Prize (co-presenter)

2014/07 - 日本炎症・再生医学会日本炎症・再生医学会優秀演題賞(共同)

2014/05 - Japanese Stomatological Society Appointed Presenter

2013/10 - Japanese Society of Oral and Maxillofacial Surgeons Gold Ribbon Prize (co-presenter)

2013/09 - Japanese Society of Oral Implantology Gold Prize (co-presenter)

2012/10 - Japanese Society of Oral and Maxillofacial Surgeons Gold Ribbon Prize (co-presenter)

2012/10 - Japanese Society of Oral and Maxillofacial Surgeons Best Oral Presentation Prize (co-presenter)

2011/10 - Japanese Society of Oral and Maxillofacial Surgeons Best Oral Presentation Prize (co-presenter)

2008/10 - Japanese Society of Oral and Maxillofacial Surgeons Medartis Prize (co-presenter)

2008/09 - Japanese Society of Oral Implantology Gold Prize (co-presenter)

2006/10 - Japanese Society of Oral and Maxillofacial Surgeons Medartis Prize (co-presenter)

2004/10 - Japanese Society of Oral and Maxillofacial Surgeons Gold Ribbon Prize (co-presenter)

2003/10 - Japanese Society of Oral and Maxillofacial Surgeons Gold Ribbon Prize (co-presenter)

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Association Membership(s) (25)：

International Society of Oral Care , Japanese Society of Oral Care , Japanese Society for Head and Neck Cancer , Global Platform for Dental Patient Safety , Japanese Society of Dentistry for Medically Compromised Patient , Japanese Board of Cancer Therapy , Japanese Society for Oral Tumors , Japanese Stomatological Society , The Stomatological Society, Japan , Asian Association of Oral and Maxillofacial Surgeons , The Japanese Society for Regenerative Medicine , Japanese Society of Oral Implantology , The Japanese Society for Jaw Deformities , The Japanese Society for Tissue Engineering , 日本口蓋裂学会 , Japanese Association for Oral Biology , Japan Society of Plastic and Reconstructive Surgery , The Japanese Society of Inflammation and Regeneration , Academy of Osseointegration , International Association of Oral and Maxillofacial Surgeons , Japanese Society of Oral Therapeutics and Pharmacology , Japanese Society for the Temporomandibular Joint , Japanese Academy of Maxillofacial Implants , Japan Prosthodontic Society , Japanese Society of Oral and Maxillofacial Surgeons

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