Research keywords (3)：
melanoma
, Oncoimmunology
, Dermatology
Research theme for competitive and other funds (18)：
2023 - 2026 Development of novel assist tool for the diagnosis of skin cancer by the active measurement of effective thermal conductivity
2021 - 2025 線溶系制御因子を標的とした新規複合的がん免疫療法の確立
2021 - 2024 Investigation for the roles of IL-17/LL37 signaling in melanoma
2021 - 2024 Anti-PD-1 plus TM5614 immunotherapy for unresectable malignant melanoma: Protocol for an investigator-initiated, open-label, single-arm, multicentre, phase 2 clinical trial
2020 - 2023 能動的精密表面温度計測を用いた熱パルスレーダ-による癌の生体内診断
2018 - 2021 Treatment of melanoma with IL-36
2016 - 2020 Early diagnosis and low invasive treatment of cancer by micro/nano thermal engineering
2018 - 2020 免疫チェックポイント阻害薬使用による免疫関連副作用予測システムの開発
2018 - 2019 非侵襲熱物性計測による皮膚腫瘍浸潤度測定法の開発
2016 - 2019 Development of novel immune therapy for melanoma by targeting tumor associated macrophages
2014 - 2017 Investigation of subpopulation of skin resident macrophages.
2013 - 2016 Development of novel immunotherapy for malignant melanoma by targeting MDSC.
2012 - 2014 Role of Foxp3-positive regulatory T cells in moyamoya disease
2011 - 2013 The effect of myeloid derived suppressor cells on the induction of peripheral tolerance
2005 - 2007 悪性黒色腫に対する新規樹状細胞療法の開発
2007 - 2007 悪性黒色腫に対する新規免疫療法の開発
2006 - 2006 感温磁性体素子と平面コイルを用いた3次元温熱療法による皮膚癌治療法の開発
2005 - 2006 Investigation for the methods of enhanced tumor vaccination using apoptosis-resistant dendritic cells manipulated by transfection of small-interfering RNAs responsible for the apoptosis of dendritic cells
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Papers (288)：
Emi Yamazaki, Taku Fujimura, Manami Takahashi-Watanabe, Satsuki Tada, Chisako Kitayama, Ryo Amagai, Yumi Kambayashi, Masahiro Watanabe, Masamitsu Maekawa, Nariyasu Mano, et al. Decreased serum levels of IL-4 correlate with the efficacy of the PAI-1 inhibitor TM5614 in patients with malignant melanoma refractory to anti-PD-1 antibodies: post hoc study of TM5614-MM trial. The British journal of dermatology. 2024
Yusuke Muto, Yumi Kambayashi, Hiroshi Kato, Satoru Mizuhashi, Takamichi Ito, Takeo Maekawa, Shoichiro Ishizuki, Hiroshi Uchi, Shigeto Matsushita, Yuki Yamamoto, et al. Three-Year Analysis of Adjuvant Therapy in Postoperative Melanoma including Acral and Mucosal Subtypes. Cancers. 2024. 16. 15
Yoji Hirai, Jun Sakurai, Shiho Yoshida, Takashi Kikuchi, Toshiharu Mitsuhashi, Tomoko Miyake, Taku Fujimura, Riichiro Abe, Hiroki Fujikawa, Hikari Boki, et al. Phase I/II clinical trial of brentuximab vedotin for pretreated Japanese patients with CD30-positive cutaneous T-cell lymphoma. The Journal of dermatology. 2024
Taku Fujimura, Koji Yoshino, Hiroshi Kato, Satoshi Fukushima, Shoichiro Ishizuki, Atsushi Otsuka, Shigeto Matsushita, Ryo Amagai, Yusuke Muto, Emi Yamazaki, et al. Phase II, multicenter study of plasminogen activator inhibitor-1 inhibitor (TM5614) plus nivolumab for treating anti-PD-1 antibody-refractory malignant melanoma: TM5614-MM trial. The British journal of dermatology. 2024
Generation of B7H1-expressing CD11b+Gr1+ myeloid derived suppressor cells (MDSCs) during immune-modulatory therapy for B16F10 melanoma.
(第37回日本研究皮膚科学会 2012)
Comparison of immunosuppressive cells and immunomodulatory cells in Angiosarcoma; the possible novel supportive therapies for angiosarcoma.
(第37回日本研究皮膚科学会 2012)
Comparison of Foxp3+ regulatory T-cells and CD163+ macrophages in invasive and non-invasive extramammary Paget’s disease.
(第37回日本研究皮膚科学会 2012)
Imiquimod augments the expression of B7H1 on CD11b+Gr1+ myeloid derived suppressor cells (MDSCs) in B16F10 melanoma
(European Society for Dermatological Research 2012)
- 2004 Tohoku University Graduate School, Division of Medicine
- 1998 Tohoku University Faculty of Medicine
Professional career (1)：
医学博士 (Tohoku University)
Work history (7)：
2023/04 - 現在 Tohoku University Department of Dermatology Associate professor
2017/09 - 2023/03 東北大学病院 皮膚科 講師
2010/08 - 2017/08 東北大学医学系研究科皮膚科学分野 助教
2007/07 - 2010/07 Department of Dermatology, University of Heidelberg Research Fellow
2004/04 - 2007/06 東北大学医学部付属病院 病院助手 助手
2002/10 - 2003/12 東北大学医学部免疫学教室 大学院生 大学院生
2000/07 - 2002/06 北海道大学遺伝子制御研究所免疫制御分野 大学院生 大学院生
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Committee career (2)：
2018/09 - 現在 日本皮膚科学会 皮膚リンパ腫治療安全検討ワーキンググループ
2017/04 - 現在 日本皮膚科学会 皮膚悪性腫瘍ガイドライン委員
Awards (4)：
2018/04 - 日本臨床皮膚科学会 ポスター賞 銀賞
2016/05 - Japan Skin Cancer Society Japan Skin Cancer Society Award Immunomodulatory effect of peritumoral administration of interferon-beta on melanoma through tumor-associated macrophages.
