Rchr
J-GLOBAL ID：200901052244356786
Update date: Oct. 04, 2024
Yoshioka Yasuhiro
ヨシオカ ヤスヒロ | Yoshioka Yasuhiro
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.setsunan.ac.jp/
Research field (3)：
Pharmacology
, Pharmaceuticals - health and biochemistry
, Neuroscience - general
Research theme for competitive and other funds (19)：
- 2024 - 2027 筋萎縮性側索硬化症の新規治療薬としてのβ3受容体作用薬の有用性に関する研究
- 2019 - 2022 A study on apelin receptor agonists as a new medicine for the treatment of glaucoma
- 2015 - 2018 A study on apelin as a new therapeutic target for glaucoma using apelin deficiency mouse
- 2013 - 2016 The utility of adrenaline beta3 receptor agonist as a new drug for Parkinson's disease
- 2012 - 2015 Research on the apelin as a therapeutic target molecule in ischemic retinopathy using genetically modified animals
- 2012 - 2013 新規パーキンソン病治療薬としてのβ3受容体アゴニストの開発
- 2009 - 2011 Research on the onset and progression of amyotrophic lateral sclerosis using genetically modified animals
- 2007 - グリア細胞を介した神経細胞保護作用に関する研究
- 2003 - 2004 Modulation of apoptosis by activation of protein kinasse G
- 2001 - 2002 Dual effect of nitric oxide on cell death : Induction and protection of apoptosis
- 1999 - 2000 Effects of nitric oxide on pain perception by primary afferent neurons in inflammation
- Mechanisms of cytoprotection by nitric oxide
- Mechanisms of cell injury by nitric oxide.
- Correlation of tyrosine phosphorylation and cell death.
- 一酸化窒素による細胞保護機構
- 一酸化窒素による細胞障害機構
- 抗酸化酵素の活性測定
- 細胞内抗酸化系を活性化させる化合物の探索
- 酸化的ストレスによるアポトーシスの誘導機構について
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Papers (30)：
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Akiko Yamamuro-Tanabe, Yu Oshima, Takumi Iyama, Yuki Ishimaru, Yasuhiro Yoshioka. Proteasome inhibitors induce apoptosis by superoxide anion generation via NADPH oxidase 5 in human neuroblastoma SH-SY5Y cells. Journal of pharmacological sciences. 2024. 155. 2. 52-62
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Akiko Yamamuro-Tanabe, Yasuhiro Kosuge, Yuki Ishimaru, Yasuhiro Yoshioka. Schwann cell derived-peroxiredoxin protects motor neurons against hydrogen peroxide-induced cell death in mouse motor neuron cell line NSC-34. Journal of Pharmacological Sciences. 2023. 153. 2. 73-83
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Akiko Yamamuro-Tanabe, Yurika Mukai, Wataru Kojima, Siyuan Zheng, Naoko Matsumoto, Shoho Takada, Mao Mizuhara, Yasuhiro Kosuge, Yuki Ishimaru, Yasuhiro Yoshioka. An Increase in Peroxiredoxin 6 Expression Induces Neurotoxic A1 Astrocytes in the Lumbar Spinal Cord of Amyotrophic Lateral Sclerosis Mice Model. Neurochemical Research. 2023
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Yasuhiro Yoshioka, Yuta Sugino, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda. Dopamine inhibits the expression of proinflammatory cytokines of microglial cells through the formation of dopamine quinone in the mouse striatum. Journal of Pharmacological Sciences. 2022. 148. 1. 41-50
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石丸侑希, 柴垣郁弥, 山室晶子, 吉岡靖啓, 前田定秋. 糖尿病モデルマウスにおける高脂肪食負荷による網膜神経変性に対するアペリン-APJシステムの保護作用. 眼薬理. 2021. 35. 1. 94-97
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MISC (34)：
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Yasuhiro Yoshioka, Eriko Ikuta, Hisatsugu Kadoi, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda. Involvement of MRP1 in noradrenaline-induced astrocyte-mediated neuroprotecion. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 209P-209P
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Yuki Ishimaru, Sachi Aichi, Chihiro Kobayashi, Hideki Fujiwara, Ai Sugimoto, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda. Effect of apelin deficiency on upregulation of fibronectin expression in a mouse model of ischemic retinopathy. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 163P-163P
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Yuta Sugino, Yasuhiro Yoshioka, Shogo Kotera, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda. Loss of dopaminergic neuron enhanced the cytokine production in the mouse brain. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 177P-177P
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Akihide Sumino, Yuki Ishimaru, Chihiro Morioka, Daiki Kajioka, Takumi Morita, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda. Apelin protects retinal neuronal injury in a mouse model of glaucoma. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 92P-92P
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Yuta Sugino, Yasuhiro Yoshioka, Takuma Nishizawa, Yoshiko Wada, Shougo Kotera, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda. Dopamine attenuates LPS-induced expression of cytokines through the inhibition of microtubule-dependent nuclear transport of NF-kappa B p65 in microglial cells. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 178P-178P
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Patents (1)：
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網膜神経保護作用を有するアペリン受容体アゴニストを含有する医薬組成物
Books (3)：
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内分泌疾患 代謝疾患
オーム社 2018
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循環器疾患・救急医療 血液疾患
オーム社 2017
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Degenaration and Regenaration in Neurons, 2006: 109-123
Research Signpost 2006 ISBN:8130801256
Lectures and oral presentations (288)：
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アストロサイトと神経細胞の混合培養系における化学的虚血による遅発性神経細胞死に対するノルアドレナリンによるアストロサイトを介した神経保護作用
(日本薬学会第144年会 2024)
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断続的断食が糖尿病モデルマウスの網膜神経障害に及ぼす影響
(日本薬学会第144年会 2024)
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Astrocyte-mediated neuroprotective effect of noradrenaline on chemical ischemia-induced delayed neuronal cell death.
(第97回日本薬理学会年会 2023)
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Fasting alleviates NMDA-induced retinal ganglion cell death in mice
(第97回日本薬理学会年会 2023)
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網膜色素変性症モデルマウスの視細胞障害に対するグルコーストランスポーター阻害薬の保護作用
(第73回 日本薬学会関西支部総会・大会 2023)
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Education (2)：
- - 2000 Osaka University Graduate School, Division of Pharmaceutical Sciences
- - 1998 Osaka University Faculty of Pharmaceutical Science
Professional career (3)：
- 薬学士 (大阪大学)
- 博士(薬学) (大阪大学)
- Master (Pharmaceutical Sciences) (Osaka University)
Committee career (3)：
- 2007 - 現在 日本薬理学会 学術評議員
- 2018/10 - 2020/09 日本薬理学会 代議員
- 2014/10 - 2016/09 日本薬理学会 代議員
Association Membership(s) (6)：
NEUROSCIENCE
, 米国神経科学会
, 日本生化学会
, 日本神経化学会
, 日本薬理学会
, 日本薬学会
