Rchr
J-GLOBAL ID：200901052583820378
Update date: Mar. 13, 2024
Nishimura Ken
ニシムラ ケン | Nishimura Ken
Affiliation and department：
Job title：
Professor
Research field (1)：
Medical biochemistry
Research keywords (1)：
Stem cell biotechnology, Gene regulation
Research theme for competitive and other funds (19)：
- 2023 - 2026 Cell fate decision by dose of transcription factors
- 2022 - 2024 複数・大量タンパク導入システムを用いたスーパーエクソソームによる肝再生療法開発
- 2021 - 2024 Mechanistic analysis of somatic cell reprogramming using paused iPSCs
- 2019 - 2022 Molecular dynamics of epigenomic transcriptional regulation by Klf4 in iPSC generation
- 2019 - 2021 Safe and efficient selection of differentiated cells by stage-specific gene expression from auto-erasable vector
- 2017 - 2021 Reprogramming of cell morphology and functions by Klf4 during iPSC generation
- 2018 - 2021 細胞の運命決定時におけるパイオニア転写因子量依存的な遺伝子発現制御
- 2017 - 2019 A Tcl1-mediated method to generate iPSCs with reduced genomic mutations
- 2016 - 2019 Non-invasive imaging of UCP1 expression in live mice
- 2016 - 2019 Spatially and time-dependent analysis of initial phase of epigenetic regulation in X chromosome reactivation
- 2018 - 2019 再生医療の安全性を向上させる高純度分化組織の単離法
- 2017 - 2018 代謝リプログラミングの調節を介したゲノム変異の少ないiPS細胞の樹立
- 2017 - 2018 再生医療の安全性を向上させる高純度分化組織の単離法
- 2014 - 2017 A novel gene therapy by full-length coagulation factor VIII
- 2014 - 2016 Mechanistic analysis of iPSC production using paused iPSC
- 2014 - 2016 Development of novel molecular imaging method for visualizing pluripotency of iPS cells
- 2013 - 2016 Analysis of the transcription factor network during the early stage of iPSC production
- 2012 - 2014 Establishment of safe and efficient differentiation system using automatic removal vector
- 2011 - 2013 細胞質持続発現型RNAベクターを用いた高効率かつ安全な分化誘導方法の確立
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Papers (67)：
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Utsugi, Yuki, Nishimura, Ken, Yamanaka, Satoshi, Nishino, Kohei, Kosako, Hidetaka, Sawasaki, Tatsuya, Shigemori, Hideyuki, Wandless, Thomas J, Miyamae, Yusaku. Ubiquitin-Derived Fragment as a Peptide Linker for the Efficient Cleavage of a Target Protein from a Degron. ACS chemical biology. 2024. 19. 2. 497-505
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Takumi Kishimoto, Ken Nishimura, Kana Morishita, Aya Fukuda, Yusaku Miyamae, Yutaro Kumagai, Kimio Sumaru, Mahito Nakanishi, Koji Hisatake, Masayuki Sano. An engineered ligand-responsive Csy4 endoribonuclease controls transgene expression from Sendai virus vectors. Journal of biological engineering. 2024. 18. 1. 9-9
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Sekiguchi, Yuya, Fukuda, Aya, Nishimura, Ken, Hisatake, Koji. Engineering Critical Residues of SOX9 Discovers a Variant With Potent Capacity to Induce Chondrocytes. STEM CELLS. 2023. Epub
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Arun Kumar Burramsetty, Ken Nishimura, Takumi Kishimoto, Muhammad Hamzah, Akihiro Kuno, Aya Fukuda, Koji Hisatake. Locus-Specific Isolation of the Nanog Chromatin Identifies Regulators Relevant to Pluripotency of Mouse Embryonic Stem Cells and Reprogramming of Somatic Cells. International Journal of Molecular Science. 2022. 23. 23. 15242
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西村 健, 相澤 志穂, 久武 幸司. iPS細胞誘導におけるX染色体再活性化. 医学のあゆみ. 2022. 283. 9. 871-874
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MISC (3)：
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Ken Nishimura, Hiroaki Segawa, Mahito Nakanishi. Development of novel defective sendai virus vectors capable of expressing therapeutic genes persistently. JOURNAL OF GENE MEDICINE. 2008. 10. 4. 444-444
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Ken Nishimura, Hiroaki Segawa, Takahiro Goto, Mariko Morishita, Takemasa Sakaguchi, Tetsuya Yoshida, Kozo Takayama, Mahito Nakanishi. Persistent gene expression from a novel RNA virus vector based on Sendai virus cl.151 STRAIN. JOURNAL OF GENE MEDICINE. 2006. 8. 12. 1457-1457
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Takahiro Goto, Mariko Morishita, Ken Nishimura, Mahito Nakanishi, Atsushi Kato, Jumpei Ehara, Kozo Takayama. Novel mucosal insulin delivery systems based on fusogenic liposomes. Pharmaceutical research. 2006. 23. 2. 384-91
Patents (7)：
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末梢血単球由来多能性幹細胞作製方法
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末梢血単球由来多能性幹細胞作製方法
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多能性幹細胞作製用ベクター材料及びこれを用いた多能性幹細胞作製方法
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多能性幹細胞作製用ベクター材料及びこれを用いた多能性幹細胞作製方法
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改良された持続感染型センダイウイルスベクター
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Lectures and oral presentations (61)：
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Discovery of a novel SOX9 mutant with potent capacity to induce chondrocytes
(The 36th Annual Meeting of the Japanese Society of Cartilage Metabolism)
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Mechanistic analysis of chromosome-wide epigenetic change during iPSC generation using Klf4-dose dependent reprogramming system
(The 20th International Joint Mini-Symposium on Molecular and Cell Biology among KU-NTU-UT)
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iPS細胞誘導過程において二相性の機能を有するE2F4の解析
(第45回日本分子生物学会年会)
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Dual function of E2F4 on iPSC generation
(TGSW2022)
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A dCas9 based method can identify novel regulators of Nanog and pluripotency
(ISSCR2022)
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Work history (1)：
- 2017/08 - 現在 国立大学法人筑波大学 医学医療系 准教授
Awards (1)：
- 2018/04 - 産業技術総合研究所 産業技術総合研究所 平成29年度理事長賞(研究)
Association Membership(s) (2)：
THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, The Molecular Biology Society of Japan
