SATO Koichi

サトウコウイチ | SATO Koichi

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Research field (1)： Veterinary medicine

Research keywords (5)：オルガノイド , がん微小環境 , 消化管微小環境 , 消化管炎症 , 消化管運動

Research theme for competitive and other funds (18)：

2024 - 2027 非アルコール性脂肪肝炎の病態発症機構の解明
2021 - 2024 PP2A活性制御を軸とした癌ニッチにおける癌関連筋線維芽細胞CAFsの役割解明
2018 - 2021 Role of increased SET expression in myofibroblasts in the "cancer niche"
2015 - 2017 Development of the new drug transmission absorption examination model by two phase culture system of intestinal epithelium cell and myofibroblast
2008 - 2013 Studies on the phased immune-barrier systems in gut-liver axis focusing on immune responses of mesenchymal cells

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Papers (86)：

Shunta Ikeda, Sana Ando, Nana Kishida, Keiko Tanaka, Masashi Sakurai, Yusuke Sakai, Shinya Ayabe, Saori Mizuno-Iijima, Atsushi Yoshiki, Kenichi Nakashima, et al. Two Distinct Mechanisms of PP2A Regulation by Methylesterase PME-1 Are Both Essential for Mouse Development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2025. 39. 9. e70554
Takashi Matsuwaki, Koichi Sato, Maho Urabe, Nayana Wijayawardhane. VetEd Asia 2024: a symposium to promote veterinary education and collaboration. Journal of Veterinary Science. 2025
Nobuyuki Fujiwara, Ryouichi Tsunedomi, Yuta Kimura, Masao Nakajima, Shinobu Tomochika, Shuhei Enjoji, Takashi Ohama, Koichi Sato, Hiroaki Nagano. Protein phosphatase 6 promotes stemness of colorectal cancer cells. Cancer science. 2024
Sana Ando, Keiko Tanaka, Maharu Matsumoto, Yuki Oyama, Yuri Tomabechi, Atsushi Yamagata, Mikako Shirouzu, Reiko Nakagawa, Noriaki Okimoto, Makoto Taiji, et al. The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction. Journal of Biological Chemistry. 2024. 300. 5. 107277-107277
Naoki Kohyanagi, Nao Kitamura, Shunta Ikeda, Shusaku Shibutani, Koichi Sato, Takashi Ohama. PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells. The Journal of biological chemistry. 2023. 105584-105584

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MISC (33)：

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Books (4)：

Lectures and oral presentations (95)：

リン酸化酵素CHK1はがん抑制因子PP2Aとその阻害タンパク質PME-1との結合を促進する
(第47回日本分子生物学会年会 2024)
CHK1はがん抑制因子PP2Aをリン酸化することでPP2A阻害タンパク質PME-1との結合を促進する
(第167回日本獣医学会学術集会 2024)
NASH発症制御におけるPP2Aメチル化の役割
(2024)
CHK1 promotes PP2A and PME-1 association through the phosphorylation of PP2Ac The 5th Japan-Taiwan Bilateral Conference on Protein Phosphatase
(2024)
NanoBiT法を用いたPDK1-Aktタンパク質間相互作用のリアルタイム動態解析
(第46回日本分子生物学会年会 2023)

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Education (3)：

1987 - 1988 The University of Tokyo
1985 - 1987 University of Miyazaki
1981 - 1985 University of Miyazaki Faculty of Agriculture Department of Veterinary Medicine

Professional career (1)：

Work history (13)：

2024/04 - 現在 Vice President (Research Promotion), Yamaguchi University
2012/05 - 現在 Yamaguchi University Joint Faculty of Veterinary Medicine
2023/01 - 2024/03 Assistant Vice President (Academic Research), Yamaguchi University
2020/04 - 2022/03 Dean, The United Graduate School of Veterinary Science, Yamaguchi University
2018/04 - 2022/03 Dean, Joint Graducate School of Veterinary Medicine, Yamaguchi University

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Awards (2)：

Association Membership(s) (3)：

日本Neurogastroenterology(神経消化器病)学会評議員 , 日本獣医学会評議員 , 日本薬理学会評議員

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