Yamashita Tetsuo

ヤマシタテツオ | Yamashita Tetsuo

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://www.med.kagawa-u.ac.jp/~cardiovasc-physiol/

Research field (3)： Physiology , Structural biochemistry , Functional biochemistry

Research keywords (7)： vascular smooth muscle , Myosin light chain phosphatase , physiology , flavoprotein , NADH dehydrogenase , respiratory chain , bioenegetics

Research theme for competitive and other funds (18)：

2024 - 2027 血液凝固系の老化促進因子としての機能解明とその制御
2022 - 2027 血液凝固系の老化促進因子としての機能解明とその制御
2021 - 2024 New therapeutic strategy for inflammatory bowel disease and inflammatory carcinogenesis from breast milk-derived probiotics
2023 - 2024 D-アロースによる炎症性腸疾患に伴う発癌抑制効果に関する研究
2022 - 2023 新規血管病治療薬開発に向けた平滑筋ミオシン軽鎖ホスファターゼの構造解析

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Papers (24)：

Xiaodong Li, Lin-Hai Kurahara, Zhixin Zhao, Feiyan Zhao, Ryo Ishikawa, Kiyomi Ohmichi, Gaopeng Li, Tetsuo Yamashita, Takeshi Hashimoto, Mayumi Hirano, et al. The therapeutic effect of proteinase-activated receptor-1 antagonist on colitis-associated carcinogenesis. Cellular and Molecular Gastroenterology and Hepatology. 2024
Keizo Hiraishi, Feiyan Zhao, Lin-Hai Kurahara, Xiaodong Li, Tetsuo Yamashita, Takeshi Hashimoto, Yoko Matsuda, Zhihong Sun, Heping Zhang, Katsuya Hirano. Lactulose Modulates the Structure of Gut Microbiota and Alleviates Colitis-Associated Tumorigenesis. Nutrients. 2022. 14. 3
Feronika Heppy Sriherfyna, Minenosuke Matsutani, Kensuke Hirano, Hisashi Koike, Naoya Kataoka, Tetsuo Yamashita, Eiko Nakamaru-Ogiso, Kazunobu Matsushita, Toshiharu Yakushi. The Auxiliary NADH Dehydrogenase Plays a Crucial Role in Redox Homeostasis of Nicotinamide Cofactors in the Absence of the Periplasmic Oxidation System in Gluconobacter oxydans NBRC3293. Applied and environmental microbiology. 2021. 87. 2
Liu W, Hashimoto T, Yamashita T, Hirano K. Coagulation factor XI induces Ca²⁺ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1. American journal of physiology. Cell physiology. 2019. 316. 3. C377-C392
Tetsuo Yamashita, Daniel Ken Inaoka, Tomoo Shiba, Takumi Oohashi, So Iwata, Takao Yagi, Hiroaki Kosaka, Hideto Miyoshi, Shigeharu Harada, Kiyoshi Kita, et al. Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors. Scientific Reports. 2018. 8. 1. 2427-2427

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MISC (52)：

Purification of enzymatically active ternary complex of myosin light chain phosphatase by using yeast expression system. 2022. 48. 72-73
YAMASHITA Tetsuo, HASHIMOTO Takeshi, IGARASHI Junsuke, KOSAKA Hiroaki, HIRANO Katsuya. N-terminal region of apoptosis-inducing factor facilitates dimer formation by stabilizing the charge transfer complex. Journal of Physiological Sciences. 2020. 70. Supplement 1. S137-S137
平野健輔, Sriherfyna Feronika Heppy, 松谷峰之介, 片岡尚也, 山下哲生, 小木曾映子[中丸], 松下一信, 薬師寿治. Gluconobacter属酢酸菌においてII型NADH脱水素酵素によるNADPH酸化が生育に及ぼす影響. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [1T06a-01]
劉文華, 橋本剛, 山下哲生, 平野勝也. 血液凝固第XI因子の血管機能調節因子としての新たな機能の発見. 日本生理学雑誌. 2019. 81. 2. 35-35
SRIHERFYNA Feronika Heppy, EMOTO Shoko, MATSUTANI Minenosuke, KOIKE Hisashi, KATAOKA Naoya, YAMASHITA Tetsuo, NAKAMARU-OGISO Eiko, MATSUSHITA Kazunobu, YAKUSHI Toshiharu. Biochemical and physiological properties of the two type-II NADH dehydrogenases of Gluconobacter oxydans NBRC3293. 2019. 53rd. 54-54

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Books (1)：

Biochemistry and Molecular Biology of Vitamine B6 and PQQ-dependent Protein
Birkhauser/Switzerland 2000

Lectures and oral presentations (56)：

M20 subunit inhibits auto-dephosphorylation of MYPT1 subunit in myosin light chain phosphatase
(The annual meeting of the physiological society of Japan 2024)
Proteinase-activated receptor 1 antagonist mitigated experimental colitis and inhibited associated tumorigenesis in mouse model
(The 75th Annual Meeting of the PSJ Chugoku-Shikoku Division 2023)
The therapeutic effect of D-allose on colitis-associated carcinogenesis
(The 8th International Symposium of International Society of Rare Sugars 2023)
酵母発現系を用いた機能的ヘテロ3量体ミオシン軽鎖ホスファターゼの調製
(日本生体エネルギー研究会第48回討論会 2022)
機能的ヘテロ3量体ミオシン軽鎖ホスファターゼの調製
(第74回日本生理学会中国四国地方会 2022)

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Works (2)：

酵母シングルサブユニット NADH-quinone oxidoreductase (Ndi1) の構造解析
2006 -
酵母シングルサブユニット NADH-quinone oxidoreductase (Ndi1) のキノン結合部位の解析
2006 -

Education (3)：

2001 - 2004 Graduate School of Pharmaceutical Sciences, The University of Tokyo
1998 - 2000 Yamaguchi University
1993 - 1997 Yamaguchi University Faculty of Agriculture

Professional career (1)：

pharmaceutical sciences (The University of Tokyo)

Work history (5)：

2006 - 現在 Kagawa University Faculty of Medicine Assistant professor
2004 - 2006 The Scripps Research Institute Research Associate
2000 - 2001 The University of Tokyo Graduate School of Medicine
2000 - 2001 Graduate School of Medicine, The University of Tokyo, Research subsidiary
2000 - Yamaguchi University Faculty of Agriculture

Association Membership(s) (3)：

日本生理学会 , 日本生化学会 , ミトコンドリア学会

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