Honke Koichi

ホンケコウイチ | Honke Koichi

Affiliation and department：
Other affiliations (1)：

高知大学医学部教授

Homepage URL (1)： http://www.kochi-ms.ac.jp/~ff_bichm/index.htm

Research field (2)： Pathobiochemistry , Medical biochemistry

Research keywords (3)：脂質生物学 , 糖鎖生物学 , 生化学

Research theme for competitive and other funds (28)：

2021 - 2024 脳特異的リン脂質分子種がつくる神経細胞膜機能ドメインの解明
2016 - 2019 The transport mechanism of the lactate transporter between Sertoli cells and spermatocytes and the role of seminolipid in it.
2015 - 2019 Characterization of combination effects of molecular targeted reagents based on the cell membrane bi-molecular cancer target
2015 - 2018 Integrative understanding of linkage between molecular structures and functions of glycosphingolipids in signal regulation
2014 - 2017 Visualisation of the marker for oligodendrocytes by imaging mass spectrometry

2013 - 2015 Identification of sialyl Lewis antigen carrier proteins involved in the metastasis of lung cancer and development of diagnostic method to measure them

2012 - 2015 O-glycosylation by GalNAc-T3 in pancreatic cancer

2010 - 2011 Characterization of signaling pathways that are regulated through cell surface molecular interaction in B cell lymphoma.

2010 - 2011 Bioinformation Produced by Molecular Interactions in The Membrane Microdomains

2009 - 2011 Molecular Mechanisms to Regulate The Metabolism of Water and Electrolytes

2004 - 2009 病態における膜マイクロドメイン糖鎖機能の解明

2005 - 2006 Molecular mechanism of male infertility caused by arrest of spermatogenesis

2002 - 2006 硫酸化糖脂質の役割と欠損による病態

2001 - 2005 Integrated analyses of biological functions of sugar chains : Glycomics

2003 - 2004 Production of autoantibodies and an animal model of autoimmune disease using a knockoutmouse

2001 - 2002 SULFATED GLYCOLIPID THAT REGULATES DEVELOPMENT OF MALE GERM CELLS

2001 - 2001 新しいトランスメンブランシグナリングとしての糖鎖シグナルネットワーク

1999 - 1999 ヒト腎がん特異的遺伝子発現機構の解析

1997 - 1998 硫酸化糖脂質の組織特異的発現機序と生理機能

1995 - 1996 MECHANISMS OF AUTONOMOUS PROLIFERATION OF HUMAN RENAL CANCER CELLS

1995 - 1995 糖脂質硫酸転移酵素の活性発現機序

1994 - 1994 糖脂質硫酸転移酵素の活性発現機序

1993 - 1993 アリルスルファターゼ欠損症の遺伝子異常

1992 - 1993 Identification of glycolipid-affinity proteins with carbohydrate probes and elucidation of their physiological significance

1991 - 1991 脳の発育に伴う細胞表層糖鎖の発現

1987 - 1987 蛋白キナーゼによる癌の水解酵素のリン酸化とその意義

1986 - 1987 Study on ganglioside syntheses

1986 - 1986 スフィンゴリピドーシスの新しい病変-脳の分化異常の観点に基づく病因の研究

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Papers (178)：

山下竜幸, 王飛霏, 馬場伸育, 沈淵, 高木涼, 都留映美, 津田雅之, 相良祐輔, 前田長正, 本家孝一. 硫酸化糖脂質sulfatideで刺激培養した臍帯MSC由来EVsの新生児低酸素虚血性脳症に対する治療効果の解明. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 2P-011
Keiko Nakashima, Yukie Hirahara, Taro Koike, Susumu Tanaka, Keizo Gamo, Souichi Oe, Shinichi Hayashi, Ryohei Seki-Omura, Yousuke Nakano, Chisato Ohe, et al. Sulfatide with ceramide composed of phytosphingosine (t18:0) and 2-hydroxy fatty acids in renal intercalated cells. Journal of lipid research. 2022. 63. 6. 100210-100210
Farhana Yesmin, Robiul H. Bhuiyan, Yuhsuke Ohmi, Satoko Yamamoto, Kei Kaneko, Yuki Ohkawa, Pu Zhang, Kazunori Hamamura, Nai-Kong V. Cheung, Norihiro Kotani, et al. Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins. International Journal of Molecular Sciences. 2021. 23. 1. 423-423
Hisako Kaneda, Yui Ida, Ryusuke Kuwahara, Izumi Sato, Takanari Nakano, Haruhiko Tokuda, Tsuyoshi Sato, Takayuki Murakoshi, Koichi Honke, Norihiro Kotani. Proximity Proteomics Has Potential for Extracellular Vesicle Identification. Journal of Proteome Research. 2021. 20. 7. 3519-3531
Hideaki Kuge, Izumi Miyamoto, Ken-ichi Yagyu, Koichi Honke. PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids. Journal of Lipid Research. 2020. jlr.RA120001087-jlr.RA120001087

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MISC (85)：

金子慶, 大川祐樹, 橋本登, 大海雄介, 山内祥生, 岡島徹也, 小谷典弘, 本家孝一, 古川圭子, 古川鋼一. ヒトmelanoma細胞におけるNeogenin細胞内ドメイン(NeICD)標的遺伝子の同定. 日本癌学会総会記事. 2015. 74回. E-1081
古川鋼一, 大川祐樹, 橋本登, 金子慶, 小谷典弘, 本家孝一, 大海雄介, 古川圭子. がん関連糖鎖がんマーカーとしての有用性と生物学的意義の統合的理解癌関連糖鎖との協同作用により癌形質を発現する分子群の同定と作用機構. 日本癌学会総会記事. 2015. 74回. S20-4
H. Kuge, K. Akahori, K. Yagyu, K. Honke. Membrane compartmentalization by lateral localization of phospholipid molecular species. MOLECULAR BIOLOGY OF THE CELL. 2015. 26
Noboru Hashimoto, Kazunori Hamamura, Norihiro Kotani, Keiko Furukawa, Kei Kaneko, Koichi Honke, Koichi Furukawa. Proteomic analysis of ganglioside-associated microdomain in malignant melanomas. GLYCOBIOLOGY. 2014. 24. 11. 1220-1220
Koichi Honke, Tatsuyuki Yamashita, Keiko Nio, Kaoru Miyahara, Tomoki Kosugi, Kenji Kadomatsu. Seminolipid is required for transfer of MCT4 from Sertoli cells to the spermatocyte plasma membrane where MCT4 forms a functional lactate transporter assembly with basigin. GLYCOBIOLOGY. 2014. 24. 11. 1179-1179

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Professional career (1)：

博士(医学) (北海道大学)

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