Shiina Isamu | Researcher Information

天然薬理活性化合物の全合成
Asymmetric Total Synthesis of Natural Products

Hiroharu SAKAI, Isamu SHIINA, Takahisa SHINOMIYA, Yukitoshi NAGAHARA. BRAP2 Inhibits the Ras/Raf/MEK and PI3K/Akt Pathways in Leukemia Cells, Thereby Inducing Apoptosis and Inhibiting Cell Growth. Experimental and Therapeutic Medicine. 2021. 21. 5. 463
Takayuki TONOI, Takehiko INOHANA, Ryo KAWAHARA, Teruyuki SATO, Miyuki IKEDA, Miku AKUTSU, Takatsugu MURATA, Isamu SHIINA. 4-(Dimethylamino)pyridine N-Oxide-Catalyzed Macrolactamization Using 2-Methyl-6-nitrobenzoic Anhydride in the Synthesis of the Depsipeptidic Analogue of FE399. ACS Omega. 2021. 6. 5. 3571-3577
Takayuki TONOI, Miyuki IKEDA, Teruyuki SATO, Takehiko INOHANA, Ryo KAWAHARA, Takatsugu MURATA, Isamu SHIINA. Total Synthesis of the Antitumor Depsipeptide FE399 and Its S-Benzyl Derivative: A Macrolactamization Approach. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2020. 2020. 32. 5119-5125
Takayuki TONOI, Takehiko INOHANA, Teruyuki SATO, Yuuki NODA, Miyuki IKEDA, Miku AKUTSU, Takatsugu MURATA, Yutaro MAEKAWA, Anna TANAKA, Rio SEKI, et al. Total Synthesis and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16Z,20E)-Eushearilide and (16E,20E)-Eushearilide. MOLECULES. 2019. 24. 3437. 1-12
Yuuki OBATA, Yasushi HARA, Isamu SHIINA, Takatsugu MURATA, Yasutaka TASAKI, Kyohei SUZUKI, Keiichi ITO, Shou TSUGAWA, Kouhei YAMAWAKI, Tsuyoshi TAKAHASHI, et al. N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells. CELL COMMUN SIGNAL. 2019. 17. 1. 1-15

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椎名勇. エステル・アミドって何? ラクトンって何? -理科大発! MNBAを用いた世界最速合成法の開発-. 理大科学フォーラム. 2019. 36. 6(通巻414). 28-33
椎名勇. 薬はどのような形をしているのか? -分子の形の調べ方, 掘り方と磨き方-. 「薬学図書館」(日本薬学図書館協議会機関誌)(ISSN 0386-2062)[Pharmaceutical Library Bulletin(Japan Pharmaceutical Library Association)]. 2017. 62. 3. 173-175
椎名勇, 森田明典. 新規タモキシフェン類縁体の放射線防護剤としての活性評価. 広島大学原爆放射線医科学研究所平成25年度共同利用・共同研究成果報告集(福島原発事故対応緊急プロジェクト研究). 2015. 13-13
椎名勇. 置換安息香酸無水物を用いる実用的縮合反応. ケミカルエンジニヤリング. 2006. 51. 702-706
椎名勇. 不斉触媒を活用した光学活性有機化合物の創製. (ハイテクリサーチセンター整備事業)「高度光利用グリーン科学技術研究センター」研究成果報告書. 2006. 2006. 45_46-114_117

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ペプチド
BRAP2作用増強剤
安息香酸誘導体及び脱水縮合剤、並びにエステル及びラクトンの製造方法
ユーシェアリライド類の製造方法
ユーシェアリライド類の製造方法

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「有機分子触媒の開発と工業利用」(ファインケミカルシリーズ)第21章有機触媒を用いたカルボン酸誘導体および光学活性アルコールとカルボン酸の合成,ならびに医薬品合成への応用
(株)シーエムシー出版 2018
「理工系の基礎教養化学」(理工系の基礎シリーズIII)第6章4節医薬品
丸善(株) 2016
「有機合成法実験ハンドブック」(第2版)第29章複素環の合成
丸善(株) 2015
「有機合成法実験ハンドブック」(第2版)第16章カルボニル化合物の反応
丸善(株) 2015
「大学院講義有機化学 II」(第2版)第3章カルボン酸,ケトン,アルコールなどの変換反応
東京化学同人 2015

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非環式ユーシェアリライドの合成研究
(日本化学会第102春季年会(2022) 2022)
ビオールアセオイドAの改良合成
(日本化学会第102春季年会(2022) 2022)
ナフォリダイフェン類縁体の合成研究
(日本化学会第102春季年会(2022) 2022)
コプロフィリン縮環部異性体の全合成
(日本化学会第102春季年会(2022) 2022)
7’-ヒドロキシ-2-メチルタンザワ酸Bアミドエナンチオマーの全合成
(日本化学会第102春季年会(2022) 2022)

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- 1992 Tokyo University of Science Graduate School, Division of Natural Science Department of Chemistry
- 1990 Tokyo University of Science Faculty of Science Department of Applied Chemistry

Ph.D (The University of Tokyo)

2018/04 - Tokyo University of Science, Research Institute for Science and Technology Chemical Biology Division Supported by Practical Organic Synthesis Director of Chemical Biology Division Supported by Practical Organic Synthesis
2012/04 - 2017/03 Tokyo University of Science, Research Institute for Science and Technology Research Center for Chirality Director of Research Center for Chirality
2007 - 2008 Tokyo University of Science Associate Professor
2008 - Department of Applied Chemistry, Faculty of Science, Tokyo University of Science Professor
2003 - 2007 Tokyo University of Science Associate Professor

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2022/12/01 - 2023/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
2021/12/01 - 2022/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
2020/12/01 - 2021/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
2019/12/01 - 2020/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
2018/12/01 - 2019/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2018/12/01 - 2019/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2017/12/01 - 2018/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2017/04/01 - 2018/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2016/04/01 - 2017/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2016/11/30 - 2016/11/30 15th Symposium on Chemical Approaches to Chirality Organizing Committee

2015/10/31 - 2016/10/28 The Chemical Society of Japan Delegates Committee Member

2015/11/18 - 2015/11/18 14th Symposium on Chemical Approaches to Chirality Organizing Committee

2014/04/01 - 2015/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2014/11/12 - 2014/11/12 13th Symposium on Chemical Approaches to Chirality Organizing Committee

2013/04/01 - 2014/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2013/03/01 - 2014/02/28 The Society of Synthetic Organic Chemistry, Japan Organizing Committee

2013/11/27 - 2013/11/27 12th Symposium on Chemical Approaches to Chirality Organizing Committee

2012/02/17 - 2013/02/28 The Society of Synthetic Organic Chemistry, Japan Organizing Committee

2012/09/26 - 2012/09/26 11th Symposium on Chemical Approaches to Chirality Organizing Committee

2011/04/01 - 2012/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2012/02/24 - 2012/02/24 10th Symposium on Chemical Approaches to Chirality Organizing Committee

2011/12/14 - 2011/12/14 9th Symposium on Chemical Approaches to Chirality Organizing Committee

2010/04/01 - 2011/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2010/12/01 - 2010/12/01 8th Symposium on Chemical Approaches to Chirality Organizing Committee

2010/09/29 - 2010/09/29 7th Symposium on Chemical Approaches to Chirality Organizing Committee

2009/11/25 - 2009/11/25 6th Symposium on Chemical Approaches to Chirality Organizing Committee

2008/04/01 - 2009/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2008/12/01 - 2008/12/01 5th Symposium on Chemical Approaches to Chirality Organizing Committee

2008/01/29 - 2008/01/29 4th Symposium on Chemical Approaches to Chirality Organizing Committee

2007/11/15 - 2007/11/15 3rd Symposium on Chemical Approaches to Chirality Organizing Committee

2005/11/10 - 2005/11/10 2nd Symposium on Chemical Approaches to Chirality Organizing Committee

2003/12/03 - 2003/12/03 1st Symposium on Chemical Approaches to Chirality Organizing Committee

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2021/11/25 - 9th DSANJ Digital Bio Conference AMED Invited Frame Research Results Selection
2021/04/20 - 2021 Chiba University Fungal Medicine Research Center Joint Research Project Selection
2021/02/10 - ACS Omega (ACS Publications) Cover Feature Article (2/2021)
2020/08/19 - European Journal of Organic Chemistry (European JOC) Cover Feature Article (8/2020)
2020/07/07 - Yahoo! JAPAN Headline News (7/July/2020)

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The Society of Synthetic Organic Chemistry, Japan , The Chemical Society of Japan , 9th Symposium on Chemical Approaches to Chirality , 8th Symposium on Chemical Approaches to Chirality , 7th Symposium on Chemical Approaches to Chirality , 6th Symposium on Chemical Approaches to Chirality , 5th Symposium on Chemical Approaches to Chirality , 4th Symposium on Chemical Approaches to Chirality , 3rd Symposium on Chemical Approaches to Chirality , 2nd Symposium on Chemical Approaches to Chirality , 1st Symposium on Chemical Approaches to Chirality , 15th Symposium on Chemical Approaches to Chirality , 14th Symposium on Chemical Approaches to Chirality , 13th Symposium on Chemical Approaches to Chirality , 12th Symposium on Chemical Approaches to Chirality , 11th Symposium on Chemical Approaches to Chirality , 10th Symposium on Chemical Approaches to Chirality