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J-GLOBAL ID：200901053413658963   Update date: Sep. 10, 2025

Shiina Isamu

シイナ イサム | Shiina Isamu
Affiliation and department：
Tokyo University of Science Faculty of Science Division I, Department of Applied Chemistry

About Tokyo University of Science Faculty of Science Division I, Department of Applied Chemistry


Job title： Professor
Homepage URL  (2)： http://www.rs.kagu.tus.ac.jp/shiina/indexj.html ,  http://www.tus.ac.jp/en/news/archive/20150511.html
Research field  (1)： Synthetic organic chemistry
Research keywords  (1)： Organic reaction chemistry、Natural products chemistry
Research theme for competitive and other funds  (2)：
  • 天然薬理活性化合物の全合成
  • Asymmetric Total Synthesis of Natural Products
Papers (178)：
  • Takatsugu MURATA, Hisazumi TSUTSUI, Isamu SHIINA. (E)-Selective Weinreb Amide-type Horner-Wadsworth-Emmons Reaction: Effect of Reaction Conditions, Substrate Scope, and Isolation of a Reactive Magnesium Phosphonoenolate, and Their Applications. JOURNAL OF ORGANIC CHEMISTRY. 2024. 89. 21. 15414-15435
  • Takatsugu MURATA, Kyoka KOMUKAI, Yuta SEMBA, Eri MURATA, Fumi SATO, Tomohiro TAKANO, Kaho TSUCHIYA, Chihiro MATSUDA, Anju SAKAI, Amane YONEOKA, Shunsuke TAKAHASHI, Yukitoshi NAGAHARA, Isamu SHIINA. Synthesis of BODIPY FL-tethered Ridaifen-B, RID-B-BODIPY, and Its Localization in Cancer Cells. Frontiers in Chemistry. 2024. 12. 1451468
  • Isamu SHIINA, Takashi IIZUMI, Saori TANIGUCHI, Masuhiro SUGIMOTO, Takahisa SHIMAZAKI, Yu-suke YAMAI, Go OGAWA, Tetsuro YAMADA, Shojiro SHINOHARA, Yosuke KAGEYAMA, Teppei KUBOKI, Yuki SUWA, Keita YONEKURA, Keiichi ITO, Kiyotaka TOYOYAMA, Satoru TATEYAMA, Takahiro MORI, Takatsugu MURATA. Total Synthesis of the Sesquiterpene (-)-Merrillianin. ORGANIC LETTERS. 2024. 26. 16. 3327-3331
  • Natsume M, Niwa M, Ichikawa S, Okamoto T, Tsutsui H, Usukura D, Murata T, Abe R, Shimonaka M, Nishida T, et al. Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5. bioRxiv. 2023. 300. 6. 107327
  • Yuuki OBATA, Kazuo KUROKAWA, Takuro TOJIMA, Miyuki NATSUME, Isamu SHIINA, Tsuyoshi TAKAHASHI, Ryo ABE, Akihiko NAKANO, Toshirou NISHIDA. Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells. Cell Reports. 2023. 42. 9. 113035
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MISC (23)：
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Patents (56)：
  • 新規化合物及びその製造方法、並びに医薬組成物
  • 新規化合物及びその製造方法、並びに医薬組成物
  • 抗菌組成物
  • 新規化合物及びその製造方法、並びに医薬組成物
  • 新規化合物及びその製造方法、並びに医薬組成物
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Books (27)：
  • 「有機分子触媒の開発と工業利用」(ファインケミカルシリーズ)第21章 有機触媒を用いたカルボン酸誘導体および光学活性アルコールとカルボン酸の合成,ならびに医薬品合成への応用
    (株)シーエムシー出版 2018
  • 「理工系の基礎 教養化学」(理工系の基礎シリーズIII)第6章4節 医薬品
    丸善(株) 2016
  • 「有機合成法実験ハンドブック」(第2版)第29章 複素環の合成
    丸善(株) 2015
  • 「有機合成法実験ハンドブック」(第2版)第16章 カルボニル化合物の反応
    丸善(株) 2015
  • 「大学院講義有機化学 II」(第2版)第3章 カルボン酸,ケトン,アルコールなどの変換反応
    東京化学同人 2015
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Lectures and oral presentations  (555)：
  • Ridaifen-Bによる皮膚分化調節機構の解明
    (日本薬学会第145年会 2025)
  • カルボニル基α位にメトキシ基を有するWeinrebアミド型Horner-Wadsworth-Emmons(HWE)試薬を用いたHWE反応の開発研究
    (日本化学会第105春季年会 2025)
  • Weinrebアミド型Horner-Wadsworth-Emmons(HWE)試薬を用いたHWE反応の速度論的反応機構解析
    (日本化学会第105春季年会 2025)
  • 抗真菌活性化合物ユーシェアリライド類縁体の合成
    (日本農薬学会第50回大会 2025)
  • Weinreb アミド型Horner-Wadsworth-Emmons (HWE)反応を用いた M-COPA 類縁体の合成
    (日本農薬学会第50回大会 2025)
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Education (2)：
  • - 1992 Tokyo University of Science Graduate School, Division of Natural Science Department of Chemistry
  • - 1990 Tokyo University of Science Faculty of Science Department of Applied Chemistry
Professional career (1)：
  • Ph.D (The University of Tokyo)
Work history (8)：
  • 2018/04 - Tokyo University of Science, Research Institute for Science and Technology Chemical Biology Division Supported by Practical Organic Synthesis Director of Chemical Biology Division Supported by Practical Organic Synthesis
  • 2012/04 - 2017/03 Tokyo University of Science, Research Institute for Science and Technology Research Center for Chirality Director of Research Center for Chirality
  • 2007 - 2008 Tokyo University of Science Associate Professor
  • 2008 - Department of Applied Chemistry, Faculty of Science, Tokyo University of Science Professor
  • 2003 - 2007 Tokyo University of Science Associate Professor
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Committee career (61)：
  • 2024/12/01 - 2025/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
  • 2023/12/01 - 2024/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
  • 2022/12/01 - 2023/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
  • 2023/09/08 - 2023/09/10 17th Symposium on Biorelevant Chemistry Organizing Committee
  • 2021/12/01 - 2022/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
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Awards (95)：
  • 2025/02/18 - The Synthetic Organic Chemistry Award, Japan
  • 2024/09/08 - Chemistry Europe Most Accessed Article (Aug/2024)
  • 2024/08/24 - Asian Journal of Organic Chemistry Most Accessed Article (Aug/2024)
  • 2024/07/15 - Asian Journal of Organic Chemistry (Asian JOC) Cover Feature Article (7/2024)
  • 2024/04/26 - Organic Letters (ACS Publications) Cover Feature Article (4/2024)
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Association Membership(s) (17)：
The Society of Synthetic Organic Chemistry, Japan ,  The Chemical Society of Japan ,  9th Symposium on Chemical Approaches to Chirality ,  8th Symposium on Chemical Approaches to Chirality ,  7th Symposium on Chemical Approaches to Chirality ,  6th Symposium on Chemical Approaches to Chirality ,  5th Symposium on Chemical Approaches to Chirality ,  4th Symposium on Chemical Approaches to Chirality ,  3rd Symposium on Chemical Approaches to Chirality ,  2nd Symposium on Chemical Approaches to Chirality ,  1st Symposium on Chemical Approaches to Chirality ,  15th Symposium on Chemical Approaches to Chirality ,  14th Symposium on Chemical Approaches to Chirality ,  13th Symposium on Chemical Approaches to Chirality ,  12th Symposium on Chemical Approaches to Chirality ,  11th Symposium on Chemical Approaches to Chirality ,  10th Symposium on Chemical Approaches to Chirality
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