Shiina Isamu | Researcher Information

天然薬理活性化合物の全合成
Asymmetric Total Synthesis of Natural Products

Isamu SHIINA, Takashi IIZUMI, Saori TANIGUCHI, Masuhiro SUGIMOTO, Takahisa SHIMAZAKI, Yu-suke YAMAI, Go OGAWA, Tetsuro YAMADA, Shojiro SHINOHARA, Yosuke KAGEYAMA, Teppei KUBOKI, Yuki SUWA, Keita YONEKURA, Keiichi ITO, Kiyotaka TOYOYAMA, Satoru TATEYAMA, Takahiro MORI, Takatsugu MURATA. Total Synthesis of the Sesquiterpene (-)-Merrillianin. ORGANIC LETTERS. 2024. 26. 16. 3327-3331
Natsume M, Niwa M, Ichikawa S, Okamoto T, Tsutsui H, Usukura D, Murata T, Abe R, Shimonaka M, Nishida T, et al. Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5. bioRxiv. 2023. 300. 6. 107327
Yuuki OBATA, Kazuo KUROKAWA, Takuro TOJIMA, Miyuki NATSUME, Isamu SHIINA, Tsuyoshi TAKAHASHI, Ryo ABE, Akihiko NAKANO, Toshirou NISHIDA. Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells. Cell Reports. 2023. 42. 9. 113035
Takatsugu MURATA, Hisazumi TSUTSUI, Takumi YOSHIDA, Hirokazu KUBOTA, Shintaro HIRAISHI, Hiyo NATSUKAWA, Yuki SUZUKI, Daiki HIRAGA, Takahiro MORI, Yutaro MAEKAWA, Satoru TATEYAMA, Kiyotaka TOYOYAMA, Keiichi ITO, Kyohei SUZUKI, Keita YONEKURA, Natsumi SHIBATA, Teruyuki SATO, Yasutaka TASAKI, Takehiko INOHANA, Atsuhiro TAKANO, Naoki EGASHIRA, Masaki HONDA, Yuma UMEZAKI, Isamu SHIINA. First Total Synthesis of Tanzawaic Acid B. ACS Omega. 2023. 8. 30. 27703-27709
Kouhei Yamawaki, Isamu Shiina, Takatsugu Murata, Satoru Tateyama, Yutarou Maekawa, Mariko Niwa, Motoyuki Shimonaka, Koji Okamoto, Toshihiro Suzuki, Toshirou Nishida, et al. FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells. Scientific reports. 2021. 11. 1. 22678-22678

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椎名勇. エステル・アミドって何? ラクトンって何? -理科大発! MNBAを用いた世界最速合成法の開発-. 理大科学フォーラム. 2019. 36. 6(通巻414). 28-33
椎名勇. 薬はどのような形をしているのか? -分子の形の調べ方, 掘り方と磨き方-. 「薬学図書館」(日本薬学図書館協議会機関誌)(ISSN 0386-2062)[Pharmaceutical Library Bulletin(Japan Pharmaceutical Library Association)]. 2017. 62. 3. 173-175
椎名勇, 森田明典. 新規タモキシフェン類縁体の放射線防護剤としての活性評価. 広島大学原爆放射線医科学研究所平成25年度共同利用・共同研究成果報告集(福島原発事故対応緊急プロジェクト研究). 2015. 13-13
椎名勇. 置換安息香酸無水物を用いる実用的縮合反応. ケミカルエンジニヤリング. 2006. 51. 702-706
椎名勇. 不斉触媒を活用した光学活性有機化合物の創製. (ハイテクリサーチセンター整備事業)「高度光利用グリーン科学技術研究センター」研究成果報告書. 2006. 2006. 45_46-114_117

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新規化合物及びその製造方法、並びに医薬組成物
抗菌組成物
新規化合物及びその製造方法、並びに医薬組成物
新規化合物及びその製造方法、並びに医薬組成物
新規化合物及びその製造方法、並びに医薬組成物

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「有機分子触媒の開発と工業利用」(ファインケミカルシリーズ)第21章有機触媒を用いたカルボン酸誘導体および光学活性アルコールとカルボン酸の合成,ならびに医薬品合成への応用
(株)シーエムシー出版 2018
「理工系の基礎教養化学」(理工系の基礎シリーズIII)第6章4節医薬品
丸善(株) 2016
「有機合成法実験ハンドブック」(第2版)第29章複素環の合成
丸善(株) 2015
「有機合成法実験ハンドブック」(第2版)第16章カルボニル化合物の反応
丸善(株) 2015
「大学院講義有機化学 II」(第2版)第3章カルボン酸,ケトン,アルコールなどの変換反応
東京化学同人 2015

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肝癌細胞株に対するM-COPAのエンドソーム制御解析(30P-am191)
(日本薬学会第144年会 2024)
タモキシフェン類縁体リダイフェン類は,リソソームへの集積を介してより強力な細胞死を誘導する(30P-am183S)
(日本薬学会第144年会 2024)
新規マクロライド系抗菌剤の抗真菌活性ならびに抗細菌活性研究
(2023年度国際共同利用・共同研究拠点事業成果報告会(千葉大学真菌医学研究センター) 2024)
2'-デメチル-7'-ヒドロキシ-2-メチルタンザワ酸Bアミド縮環部異性体の全合成
(2023年度日本農芸化学会 2024)
Weinrebアミド型HornerWadsworth-Emmons(HWE)試薬を用いたHWE反応の実験的機構解析研究
(日本化学会第104春季年会(2024) 2024)

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- 1992 Tokyo University of Science Graduate School, Division of Natural Science Department of Chemistry
- 1990 Tokyo University of Science Faculty of Science Department of Applied Chemistry

Ph.D (The University of Tokyo)

2018/04 - Tokyo University of Science, Research Institute for Science and Technology Chemical Biology Division Supported by Practical Organic Synthesis Director of Chemical Biology Division Supported by Practical Organic Synthesis
2012/04 - 2017/03 Tokyo University of Science, Research Institute for Science and Technology Research Center for Chirality Director of Research Center for Chirality
2007 - 2008 Tokyo University of Science Associate Professor
2008 - Department of Applied Chemistry, Faculty of Science, Tokyo University of Science Professor
2003 - 2007 Tokyo University of Science Associate Professor

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2024/12/01 - 2025/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
2023/12/01 - 2024/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
2022/12/01 - 2023/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member
2023/09/08 - 2023/09/10 17th Symposium on Biorelevant Chemistry Organizing Committee
2021/12/01 - 2022/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2020/12/01 - 2021/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2019/12/01 - 2020/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2018/12/01 - 2019/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2017/12/01 - 2018/11/30 The Society of Synthetic Organic Chemistry, Japan Delegates Committee Member

2017/04/01 - 2018/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2016/04/01 - 2017/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2016/11/30 - 2016/11/30 15th Symposium on Chemical Approaches to Chirality Organizing Committee

2015/10/31 - 2016/10/28 The Chemical Society of Japan Delegates Committee Member

2015/11/18 - 2015/11/18 14th Symposium on Chemical Approaches to Chirality Organizing Committee

2014/04/01 - 2015/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2014/11/12 - 2014/11/12 13th Symposium on Chemical Approaches to Chirality Organizing Committee

2013/04/01 - 2014/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2013/03/01 - 2014/02/28 The Society of Synthetic Organic Chemistry, Japan Organizing Committee

2013/11/27 - 2013/11/27 12th Symposium on Chemical Approaches to Chirality Organizing Committee

2012/02/17 - 2013/02/28 The Society of Synthetic Organic Chemistry, Japan Organizing Committee

2012/09/26 - 2012/09/26 11th Symposium on Chemical Approaches to Chirality Organizing Committee

2011/04/01 - 2012/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2012/02/24 - 2012/02/24 10th Symposium on Chemical Approaches to Chirality Organizing Committee

2011/12/14 - 2011/12/14 9th Symposium on Chemical Approaches to Chirality Organizing Committee

2010/04/01 - 2011/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2010/12/01 - 2010/12/01 8th Symposium on Chemical Approaches to Chirality Organizing Committee

2010/09/29 - 2010/09/29 7th Symposium on Chemical Approaches to Chirality Organizing Committee

2009/11/25 - 2009/11/25 6th Symposium on Chemical Approaches to Chirality Organizing Committee

2008/04/01 - 2009/03/31 The Chemical Society of Japan Annual Meeting Organization Committee

2008/12/01 - 2008/12/01 5th Symposium on Chemical Approaches to Chirality Organizing Committee

2008/01/29 - 2008/01/29 4th Symposium on Chemical Approaches to Chirality Organizing Committee

2007/11/15 - 2007/11/15 3rd Symposium on Chemical Approaches to Chirality Organizing Committee

2005/11/10 - 2005/11/10 2nd Symposium on Chemical Approaches to Chirality Organizing Committee

2003/12/03 - 2003/12/03 1st Symposium on Chemical Approaches to Chirality Organizing Committee

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2024/04/26 - Organic Letters (ACS Publications) Cover Feature Article (4/2024)
2023/12/02 - 「The 18th TOIN International Symposium on Biomedical Engineering 2023」Best Poster Award
2023/02/13 - 2023 Chiba University Fungal Medicine Research Center Joint Research Project Selection
2022/11/05 - 「The 17th TOIN International Symposium on Biomedical Engineering 2022」Best Poster Award
2021/11/25 - 9th DSANJ Digital Bio Conference AMED Invited Frame Research Results Selection

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The Society of Synthetic Organic Chemistry, Japan , The Chemical Society of Japan , 9th Symposium on Chemical Approaches to Chirality , 8th Symposium on Chemical Approaches to Chirality , 7th Symposium on Chemical Approaches to Chirality , 6th Symposium on Chemical Approaches to Chirality , 5th Symposium on Chemical Approaches to Chirality , 4th Symposium on Chemical Approaches to Chirality , 3rd Symposium on Chemical Approaches to Chirality , 2nd Symposium on Chemical Approaches to Chirality , 1st Symposium on Chemical Approaches to Chirality , 15th Symposium on Chemical Approaches to Chirality , 14th Symposium on Chemical Approaches to Chirality , 13th Symposium on Chemical Approaches to Chirality , 12th Symposium on Chemical Approaches to Chirality , 11th Symposium on Chemical Approaches to Chirality , 10th Symposium on Chemical Approaches to Chirality