Rchr
J-GLOBAL ID：200901054485643045   Update date: Apr. 11, 2024

Kasai Rinshi

Kasai Rinshi
Affiliation and department：
National Cancer Center Research Institute

About National Cancer Center Research Institute


Homepage URL  (1)： https://sites.google.com/view/kasai-rinshi-hp/home?authuser=0
Research field  (2)： Bio-, chemical, and soft-matter physics ,  Cell biology
Research keywords  (8)： Planar Cell Polarity ,  Super-resolution microscopy ,  membrane protein ,  蛍光顕微鏡 ,  dimer ,  G-protein coupled receptor ,  蛍光1分子観察 ,  membrane organization
Research theme for competitive and other funds  (12)：
  • 2020 - 2023 Measuring molecular properties of membrane proteins using a synthetic cell micro-environment conposed of a model cell membrane and a nanometric space
  • 2018 - 2023 Development of single-molecule methods measuring energy conversion processes of biological and synthetic molecular engines
  • 2018 - 2023 Uncovering the secrets of lipid-transporting ABC proteins
  • 2017 - 2020 Evaluating the affinity of membrane proteins and lipid raft using a patterned model membrane platform
  • 2017 - 2020 Dimerization-induced signal generation of GPCR: Single molecule observation in live cells
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Papers (47)：
  • Shigetaka Nishiguchi, Rinshi S. Kasai, Takayuki Uchihashi. Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed atomic force microscopy. Proceedings of the National Academy of Sciences. 2023
  • Nishiguchi, S., Kasai, R.S., Uchihashi, T. Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed-atomic force microscopy. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 18
  • Taisei Yamamoto, Satoshi Yasuda, Rinshi S. Kasai, Ryosuke Nakano, Simon Hikiri, Kanna Sugaya, Tomohiko Hayashi, Satoshi Ogasawara, Mitsunori Shiroishi, Takahiro K. Fujiwara, et al. A methodology for creating mutants of G-protein coupled receptors stabilized in active state by combining statistical thermodynamics and evolutionary molecular engineering. Protein Science. 2022. 31. 10
  • Taka A. Tsunoyama, Christian Hoffmann, Bo Tang, Koichiro M. Hirosawa, Yuri L. Nemoto, Rinshi S. Kasai, Takahiro K. Fujiwara, Kenichi G.N. Suzuki, Dragomir Milovanovic, Akihiro Kusumi. iTRVZ: liquid nano-platform for signal integration on the plasma membrane. 2021
  • Rurika Nagai, Ayane Sugimachi, Yasushi Tanimoto, Kenichi G N Suzuki, Fumio Hayashi, Dorothee Weikert, Peter Gmeiner, Rinshi S Kasai, Kenichi Morigaki. Functional Reconstitution of Dopamine D2 Receptor into a Supported Model Membrane in a Nanometric Confinement. Advanced biology. 2021. 5. 12. e2100636
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MISC (41)：
  • 岡本雄介, 永田紅, 笠井倫志, 木村泰久, 木岡紀幸, 木岡紀幸, 植田和光, 植田和光. ABCAサブファミリータンパク質のC末端領域の機能解明を目的としたキメラタンパク質の解析. 日本生化学会大会(Web). 2018. 91st
  • 岡本雄介, 永田紅, 笠井倫志, 楠見明弘, 楠見明弘, 木村泰久, 木岡紀幸, 植田和光, 植田和光. HDL産生の鍵を握るABCA1のC末端領域の機能解析. 日本農芸化学会大会講演要旨集(Web). 2016. 2016
  • KASAI Rinshi. Dimers are the key trigger for the GPCR’s basic signaling without ligation. 2014
  • Kasai Rinshi, Kusumi Akihiro. 2P104 Dimers are the key trigger for the GPCR's basic signaling without ligation(03. Membrane proteins,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)). Seibutsu Butsuri. 2014. 54. 1. S212
  • Yuki Shirai, Peng Zhou, Rinshi Kasai, Wonhwa Cho, Takahiro Fujiwara, Akihiro Kusumi. 3P175 Single-molecule detection of hotspots for dynamic concentration of the kappa opioid receptor(Cell biology,Poster,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014)). Seibutsu Butsuri. 2014. 54. 1. S278
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Books (8)：
  • Quantitative Biology: Dynamics of Living Systems
    Frontiers Media SA 2017
  • 医学のあゆみ GPCR研究の最前線2016 企画 飯利太朗 槙田紀子
    医歯薬出版株式会社 2016
  • 生体の科学 [増大特集] 生命動態システム科学
    医学書院 2014
  • 現代化学
    東京化学同人 2013
  • Clinical Neuroscience 月刊 臨床神経科学
    中外医学社 2013
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Lectures and oral presentations  (30)：
  • Gタンパク質共役型受容体の動的なダイマー形成:蛍光1 分子観察法による解明
    (日本農芸化学会 中部支部 第184回例会 若手シンポジウム “化学と生物のマリアージュ:若手研究者による生化学研究の新機軸” 2018)
  • Transient dimer formation of G-protein coupled receptor: single fluorescent molecule imaging in live cells
    (The 3rd Biosignal Research Center International Symposium “Modulation of GPCR signaling by membrane heterogeneity and molecular clustering” 2018)
  • Transient dimers of GPCRs are responsible for triggering GPCRs’ basic constitutive signals - A finding by the two-color single fluorescent-molecule tracking in living cells
    (Cold Spring Harbor meeting: Single Biomolecules 2018)
  • Transient GPCR dimers trigger basal signals as revealed by single-molecule imaging
    (Gordon Research Conference 2017)
  • Dynamic dimer formation of G-protein coupled receptor in the live plasma membrane: An approach by using single molecule observation
    (The 54th Japanese Biophysical Society meeting, Symposium 2016)
ｍore...
Education (3)：
  • 2000 - 2005 Nagoya University
  • 1998 - 2000 Nagoya University
  • 1994 - 1998 Kanazawa University Faculty of Science
Professional career (2)：
  • Master of Science (Nagoya University)
  • Doctor of Science (Nagoya University)
Work history (8)：
  • 2024/04 - 現在 Hoshi University
  • 2023/06 - 現在 National Cancer Center Research Institute Laboratory Head
  • 2021/04 - 2023/05 Gifu University
  • 2016/10 - 2021/03 Kyoto University Institute for Frontier Life and Medical Sicences Assistant Professor
  • 2011/04 - 2016/09 Kyoto University Institute for Frontier Medical Sciences Assistant Professor
Show all
Committee career (1)：
  • 2010/01 - 現在 日本生物物理学会 分野別専門委員
Association Membership(s) (4)：
アメリカ生物物理学会 ,  アメリカ細胞生物学会 ,  日本細胞生物学会 ,  日本生物物理学会
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