Nishida Motohiro

2020 - 2022 Molecular basis underlying Zn2+-dependent regulation of sympathetic nerve-stimulated response

2019 - 2022 Elucidation of mechanism underlying dysregulation of mitochondrial quality control in the failing heart and its therapeutic strategy

2019 - 2021 Molecular mechanism underlying induction of spontaneous excitation by GPCR and its physiological significance

2018 - 2019 Sulfur-dependent energy metabolism: sulfur respiration and its physiological role

2016 - 2019 A novel model for causing senescence via mitochondrial dysfunction by environmental factors

2016 - 2019 Elucidation of molecualr mechanism underlying maintenance of living body homeostasis by mechano-activated molecules and establishment of a strategy for exercise-mimetic drug development

2015 - 2019 Promotion of oxygen biology on the basis of international networks

2014 - 2019 Formation and regulation of ligand signals associated with accepting and activating molecular oxygen

2015 - 2018 Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pulmonary Arterial Hypertension

2013 - 2018 Comprehensive study on environmental electrophiles-mediated signal transduction pathways regulated by reactive sulfur species

2015 - 2017 Elucidation of molecualr mechanism underlying cardiac hibernation by reactive persulfide species

2014 - 2017 Role of reactive oxygen species in physiology and pathophysiology of cardiac biomechanics

2014 - 2017 Elucidation of epigenetic regulation of gene expresson involved in maintaining cardiac function and metabolism

2013 - 2016 Study on the regulation of cardiac homeostasis by formation of TRPC3/6 channel protein complex

2013 - 2015 Establishment of the molecualr basis underlying regulation of cardiac redox homeostasis by electrophilic signaling and its therapeutic application for heart failure

2012 - 2015 Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pathological Cardiac Remodeling

2008 - 2014 Signaling Functions of Reactive Oxygen Species

2011 - 2012 Regulation of extracellular matrix homeostasis via amino acid-operated cation channels

2008 - 2012 ROS sensor-effector regulation via cysteine modifications

2010 - 2011 Study on the role of receptor-activated cation channel TRPC3 in cardiac remodeling

2007 - 2009 Analysis of G protein signaling pathways involved in the development of heart failure and discovery of the novel therapeutic target.

2005 - 2009 mechanistic analysis of cardiac functions by building G protein signal network

2004 - 2005 Elucidation of physiological significance of direct Ca^<2+> channel-phospholipase coupling in cell fate control

2004 - 2005 PLCタンパク複合体形成による細胞死シグナル誘導のメカニズム

2002 - 2003 活性酸素によって活性化されるCa^<2+>channelの生理的役割の解明

2002 - 2003 活性酸素によるCa2+流入を介した細胞周期の制御機構の解明

2001 - 2003 Mechanism underlying polarized subcellular distribution of Ca channels and its neurobiological significance.

酸化ストレスで活性化されるCaチャネルの活性化機構の解明

Study on the mechanism of Ca channel activation by reactive oxygen species