Rchr
J-GLOBAL ID：200901054541047477
Update date: Nov. 22, 2024
Hirokawa Takatsugu
ヒロカワ タカツグ | Hirokawa Takatsugu
Affiliation and department：
Job title：
Professor
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research theme for competitive and other funds (16)：
- 2024 - 2028 Deorphanization of MFS-Type Multidrug Efflux Transporters: Inhibition of Drug Efflux and Physiological function
- 2020 - 2024 プロスタグランジン受容体を標的とした構造に基づく創薬
- 2020 - 2023 汎フィロウイルス治療薬開発に向けたドライ-ウェット融合型研究基盤の構築
- 2017 - 2020 Rational design of high functional biosupra and development of therapeutic evaluation system with disease models
- 2016 - 2020 Development of methods for modification of proteins with its application to protein drugs
- 2015 - 2019 Construction of dynamic prediction model of EGFR tyrosine kinase inhibitors efficacy for mutated EGFR based on protein three-dimensional structure analysis
- 2014 - 2017 Development of neoglycobiologics and application for drug discovery for lysosomal diseases
- 2012 - 2017 Understanding the virus-host network by post genome analysis
- 2014 - 2016 Development of small molecules that stabilize i-motif DNA structures composed in the C-rich regions.
- 2012 - 2015 Medicinal chemical study by the three-dimensional structural diversity-oriented strategy based on the characteristic steric and stereoelectronic features of cyclopropane
- 2011 - 2014 Development of neo-biologics targeted on protein-protein interaction sites
- 2008 - 2009 Development of novel glycolipids] which activate natural killer T cells to induce antitumor acivity
- 2004 - 2004 ゲノムワイドな構造・機能分類による膜蛋白質の機能理解:G蛋白質共役型受容体
- 2004 - 2004 バイオインフォマテクスの構造予測にもとづいた神経栄養因子の一塩基多型の機能解析
- 2003 - 2003 ゲノムワイドな構造・機能分類によるG蛋白質共役型受容体の機能理解
- 2002 - 2002 ゲノムワイドな膜蛋白質の構造、機能分類:G蛋白質共役型受容体への応用
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Papers (157)：
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Ryo Ishikawa, Kazuki Yanagita, Sayuri Shimada, Shogo Sasaki, Takatsugu Hirokawa, Yue Ma, Kazuo Nagasawa, Masayuki Tera. Topology-selective photo-crosslinking of G-quadruplexes via dual G-quartet and groove recognition. Chemical Communications. 2024
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Zihan Zhang, Toru Takenaga, Sarah Katharina Fehling, Manabu Igarashi, Takatsugu Hirokawa, Yukiko Muramoto, Koji Yamauchi, Chiho Onishi, Masahiro Nakano, Shuzo Urata, et al. Hexestrol, an estrogen receptor agonist, inhibits Lassa virus entry. Journal of virology. 2024. 98. 7. e0071424
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Yuya Maruyama, Yusuke Ohsawa, Takayuki Suzuki, Yuko Yamauchi, Kohsuke Ohno, Hitoshi Inoue, Akitoshi Yamamoto, Morimichi Hayashi, Yuji Okuhara, Wataru Muramatsu, et al. Pseudoirreversible inhibition elicits persistent efficacy of a sphingosine 1-phosphate receptor 1 antagonist. Nature communications. 2024. 15. 1. 5743-5743
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Genki Kudo, Takumi Hirao, Ryuhei Harada, Takatsugu Hirokawa, Yasuteru Shigeta, Ryunosuke Yoshino. Prediction of the binding mechanism of a selective DNA methyltransferase 3A inhibitor by molecular simulation. Scientific reports. 2024. 14. 1. 13508-13508
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Genki Kudo, Takumi Hirao, Ryunosuke Yoshino, Yasuteru Shigeta, Takatsugu Hirokawa. Site Identification and Next Choice Protocol for Hit-to-Lead Optimization. Journal of chemical information and modeling. 2024. 64. 11. 4475-4484
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MISC (187)：
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稲葉和恵, 海老原佳奈, 小祝孝太郎, 吉野龍ノ介, 広川貴次, 今村理世, 小島宏建, 岡部隆義, 長野哲雄, 井上英史, et al. Structure-activity relationship analysis of inhibitors targeting mosquito glutathione S-transferase Noppera-bo. 量子ビームサイエンスフェスタ(Web). 2021. 2020
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Hirokawa Takatsugu, Masakazu Sekijima, Tanaka Shigenori, Nakamura Haruki. In silico approaches to drug repositioning for COVID-19 at AMED-BINDS. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 0. 2-ES-3
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福士友理, 堀井雄登, 仲村和佳, 広川貴次, 鬼塚正義, 伊藤孝司. ガラクトシアリドーシスの治療を目指したN型糖鎖追加型カテプシンAの創製と分子機能解析. 日本生化学会大会(Web). 2020. 93rd
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中北智哉, 中北智哉, 成川真隆, 広川貴次, 三坂巧. Comparison of active and inactive models of transmembrane-domain of the sweet receptor T1R3 subunit. 日本農芸化学会大会講演要旨集(Web). 2020. 2020
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福士友理, 堀井雄登, 仲村和佳, 広川貴次, 鬼塚正義, 伊藤孝司. Development and Molecular Characterization of N-glycan-added CathepsinA. 日本糖質学会年会要旨集. 2020. 39th
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Patents (29)：
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