Research field (2)：
Tumor biology
, Pathobiochemistry
Research keywords (1)：
腫瘍細胞
Research theme for competitive and other funds (20)：
2021 - 2024 Cross-talk between cancer cells and fibroblasts during cancer progression.
2020 - 2023 消化器癌におけるNa+/H+交換輸送体5の機能解析と特異的阻害薬の開発
2016 - 2019 肝細胞がんの多様性・変幻性におけるMT1-MMP依存性分子経路の解析
2011 - 2014 細胞外マトリックス分解と細胞運動の極性形成維持機構
2010 - 2013 膜型マトリックスメタロプロテアー ゼ-1のがん悪性化形質に果たす役割の解析
2008 - 2011 Cell migration induced by alternation of extracellular matrix microenvironment
2007 - 2010 Study on mechanism of tissue degradation by membrane-type matrix metalloproteinase
2008 - 2009 膜型マトリックスメタロプロテアーゼによる細胞運動極性 制御機構
2004 - 2008 Analysis of regulatory mechanism for cell polarity formation by JNK binding molecules during migration
2005 - 2007 Functional analysis of matrix metalloproteinases associated with tissue destruction
2004 - 2005 がん浸潤の細胞運動と細胞外マトリックス分解制御機構の解析
2003 - 2004 癌細胞浸潤における細胞運動と MT-MMPの協調的制御機構の解析
2002 - 2004 Study on novel functions of membrane-type matrix metalloproteinase in tumor metastasis
2002 - 2004 がん細胞運動とマトリックスメタロプロテアーゼ活性発現の調節機構の解析
1999 - 2004 形態形成過程におけるMT1-MMPの機能発現制御機構の解析
2002 - 2003 癌細胞浸潤における細胞運動と MT-MMPの協調的制御機構の解析
2000 - 2002 癌細胞とマトリックスメタロプロテアーゼ活性発現調節機構の解明
2000 - 2001 がん浸潤における細胞運動とMMP発現の協調的制御機構の解析
1995 - 1997 ROLES OF MEMBRANE TYPE MATRIX METALLOPROTEINASE IN BREAST TUMOR METASTASIS
Study on Tumor Cell Invasion
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Papers (78)：
Yusei Shinohara, Yuki Komiya, Kashin Morimoto, Yoshio Endo, Minoru Terashima, Takeshi Suzuki, Takahisa Takino, Itasu Ninomiya, Hisatsugu Yamada, Yoshihiro Uto. Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound. Bioorganic & medicinal chemistry. 2024. 99. 117603-117603
Gerelsuren Batbayar, Akihiko Ishimura, Hanbing Lyu, Sasithorn Wanna-Udom, Makiko Meguro-Horike, Minoru Terashima, Shin-Ichi Horike, Takahisa Takino, Takeshi Suzuki. ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 lysine 4 methylation. Biochemical and biophysical research communications. 2023. 669. 19-29
Kusuma Suphakhong, Minoru Terashima, Sasithorn Wanna-Udom, Risa Takatsuka, Akihiko Ishimura, Takahisa Takino, Takeshi Suzuki. m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells. The Journal of biological chemistry. 2022. 298. 11. 102554-102554
Hirari Yamahana, Yuki Komiya, Takahisa Takino, Yoshio Endo, Hisatsugu Yamada, Chikako Asada, Yoshihiro Uto. Structure-Activity Relationships of UTX-121 Derivatives for the Development of Novel Matrix Metalloproteinase-2/9 Inhibitors. Chemical and Pharmaceutical Bulletin. 2021. 69. 10. 1017-1028
Yusei Shinohara, Itasu Ninomiya, Yoshio Endo, Takahisa Takino, Yoshihiro Uto. Development of a Novel Amiloride Derivative as a Na plus /H plus exchanger 5 selective inhibitor. CANCER SCIENCE. 2021. 112. 912-912
Hirari Yamahana, Takahisa Takino, Yoshio Endo, Takeshi Suzuki, Yoshihiro Uto. Development of a Novel Celecoxib Derivative UTX-121 as an Antimetastatic Agent. CANCER SCIENCE. 2021. 112. 695-695
- 1990 The University of Tokushima Faculty of Dentistry
Professional career (1)：
医学博士 (金沢大学)
Work history (7)：
2017/04 - 現在 Kanazawa University Institute of Liberal Arts and Science
2016/04 - 2017/03 Kanazawa University Institute of Liberal Arts and Science
2003/05 - 2016/03 Kanazawa University Cancer Research Institute
1999/10 - 2003/04 Kanazawa University
1998/01 - 1999/09 日本学術振興会 海外特別研究員(NIH)
1997/04 - 1997/12 アメリカ保健衛生研究所(NIH)客員研究員
1995/04 - 1997/03 日本学術振興会 特別研究員(がん)
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Committee career (4)：
2007 - 現在 日本結合組織学会 評議員
2005 - 現在 日本がん転移学会 評議員
2023/11 - 2025/11 日本生化学会 代議員
2018/04 - 2020/03 日本癌学会 評議員
Awards (3)：
2005 - 第9回日本がん転移学会研究奨励賞
2005 - 上原記念生命科学財団平成16年度研究奨励金
2003 - 第17回北国がん基金研究助成
Association Membership(s) (8)：
日本生化学会
, 日本結合組織学会
, 日本がん転移学会
, 日本癌学会
, Japanese Biochemical Society
, Japanese Society for Connective Tissue Research
, Japanese Association for Metastasis Research Society
, Japanese Cancer Association
