Rchr
J-GLOBAL ID：200901055025829791
Update date: Sep. 11, 2024
Yamamoto Kimiko
ヤマモト キミコ | Yamamoto Kimiko
Affiliation and department：
Job title：
Lecturer
Homepage URL (1)：
http://square.umin.ac.jp/bme/
Research field (3)：
Polymer chemistry
, Biomaterials
, Biomedical engineering
Research keywords (4)：
Mechanobiology
, メカノトランスダクション
, 血管のメカノバイオロジー
, Mechanotransduction
Research theme for competitive and other funds (23)：
- 2021 - 2025 The molecular mechanism of mechanotransduction in vascular homeostasis and disease
- 2021 - 2024 Mitochondria-mediated blood flow mechanosensing in endothelial cells
- 2019 - 2021 Bioenergetics of vascular endothelial mitochondria in response to blood flow stimuli
- 2018 - 2021 Blood flow-sensing mechanisms via lipid molecules in endothelial plasma membranes
- 2014 - 2017 Blood flow mechanotransduction in vascular endothelial cells
- 2013 - 2016 Mechanoresponses of endothelial cell membranes to fluid shear stress
- 2012 - 2014 Cloning of LDL receptors responding to fluid shear stress
- 2009 - 2014 Molecular Biomechanics of Vascular Cell Mechano-Responses
- 2010 - 2012 Blood-flow-mediated mechanotransduction in vascular endothelial cells
- 2007 - 2009 Shear-stress-induced molecular dynamics of endothelial cell membrane
- 2005 - 2009 Biomechanical force-sensing and response mechanisms in vascular cells and its application to tissue engineering
- 2006 - 2008 Ion channel-mediated blood flow-sensing mechanism in vascular endothelial cells
- 2004 - 2006 Generating blood-flow-sensing-molecule-deficient mice and analysis of their physiological functions
- 2003 - 2005 Mechano-sensing Mechanism and Mechano-Responsive Genes in Vascular Endothelial Cells
- 2003 - 2004 Imaging and analysis of subplasmalemmal Ca^<2+> dynamics by FRET
- 2002 - 2003 血管内皮細胞における流れずり応力の感知と生理機能解析に関する研究
- 2001 - 2002 Exploration of blood flow-sensing molecules in vascular endothelial cells
- 流れずり応力下での血管内皮細胞における細胞外マトリックスの動的役割
- 物理的刺激による細胞の分化誘導
- 血管内皮細胞の流れずり応力感知機構に果たすP2Xプリノセプターの役割
- Dynamicfunction of extracellular matrix on vascular endothelial cells under shear-stress condition
- Inducting the differentiation of vascular endothelial progenitor cells by loading shear stress
- Role of P2X4purinoceptors in the sensing mechanism of shear stress in endothelial cells
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Papers (80)：
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Kimiko Yamamoto, Yuji Shimogonya, Ryohei Maeno, Kenshiroh Kawabe, Joji Ando. Endothelial cells differentially sense laminar and disturbed flows by altering the lipid order of their plasma and mitochondrial membranes. American Journal of Physiology-Cell Physiology. 2023
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Kazuki Yoshida, Shota Tanihara, Yuki Miyashita, Kosuke Obayashi, Masa-aki Ito, Kimiko Yamamoto, Toshiyashu Imai, Isao Matsuoka. P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice. Scientific Reports. 2022. 12. 1
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Joji Ando, Kimiko Yamamoto. Hemodynamic Forces, Endothelial Mechanotransduction, and Vascular Diseases. Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine. 2022. 21. 2. 258-266
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Kosuke Obayashi, Kazuki Yoshida, Masa-aki Ito, Tetsuya Mori, Kimiko Yamamoto, Toshiyashu Imai, Isao Matsuoka. Synergistic Cytokine Production by ATP and PGE2 via P2X4 and EP3 Receptors in Mouse Bone-Marrow-Derived Mast Cells. Cells. 2022. 11. 4. 616-616
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Haruka Tani, Bo Li, Takashi Kusu, Ryu Okumura, Junichi Nishimura, Daisuke Okuzaki, Daisuke Motooka, Shoya Arakawa, Asuka Mori, Terukazu Yoshihara, et al. The ATP-hydrolyzing ectoenzyme E-NTPD8 attenuates colitis through modulation of P2X4 receptor-dependent metabolism in myeloid cells. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 39
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MISC (93)：
Books (2)：
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細胞のマルチスケールメカノバイオロジー
森北出版 2017 ISBN:9784627691414
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Vascular Engineering
Springer 2016 ISBN:9784431548003
Lectures and oral presentations (32)：
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Emerging roles of membrane lipids and mitochondria in endothelial cell mechanosensing
(The 2nd Joint Meeting of ESCHM-ISCH-ISB 2021 2021)
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内皮細胞の血流センシングにおける膜脂質とミトコンドリアの新しい役割
(臨床エピジェネティクス研究会 2021)
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血流シグナル伝達の新しい仕組み〜内皮細胞膜とミトコンドリアの連携プレイ〜
(第80回Blood Vessel Club 2021)
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血管内皮細胞の膜脂質を介したメカノセンシングと循環調節の仕組み
(第61回日本脈管学会総会 2020)
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内皮細胞ミトコンドリアのバイオエナジェティクスを介した血流感知機構
(第93回日本生化学会 2020)
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Education (3)：
- - 2000 The University of Tokyo
- - 2000 The University of Tokyo Graduate School, Division of Medical Sciences
- - 1987 Waseda University Faculty of Science and Engineering
Professional career (3)：
- Doctor of Medicine (The University of Tokyo)
- Doctor of Engineering (Yamagata University)
- Master of Engineering (Waseda University)
Work history (10)：
- 2016 - 現在 東京大学
- 2015 - 現在 Japan Agency for Medical Research and Development
- 2003 - 2016 The University of Tokyo Graduate School of Medicine
- 2003 - 2016 University of Tokyo, Lecturer
- 2006 - 2009 科学技術振興機構さきがけ研究員(兼任)
- 2000 - 2003 The University of Tokyo Graduate School of Medicine
- 2000 - 2003 University of Tokyo, Research Assistant
- 1997 - 2000 日本学術振興会 特別研究員
- 1997 - 2000 Japan Society for the Promotion of Science, Research Fellow
- 1989 - 1991 DuPont Japan, Central Research Center, Chemist
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Committee career (3)：
- 日本生体医工学会 代議員
- 日本バイオレオロジー学会 理事
- 日本血管生物医学会 評議委員
Association Membership(s) (8)：
PHYSIOLOGICAL SOCIETY OF JAPAN
, Biophysical Society
, The American Physiological Society
, 日本高分子学会
, 日本バイオレオロジー学会
, 日本循環器学会
, 日本血管生物医学会
, 日本生体医工学会
