Rchr
J-GLOBAL ID：200901055052354690   Update date: Nov. 19, 2024

Aoki Junken

アオキ ジユンケン | Aoki Junken
Affiliation and department：
東京大学 薬学系研究科

About 東京大学 薬学系研究科


Job title： 教授
Homepage URL  (2)： http://db.tohoku.ac.jp/whois/detail/269b5fbf825ea70139d27a5d42e4daaa.html ,  http://db.tohoku.ac.jp/whois/e_detail/269b5fbf825ea70139d27a5d42e4daaa.html
Research field  (1)： Applied biochemistry
Research keywords  (5)： lysophosphatidylserine ,  lysophosphatidic acid ,  phospholipase ,  GPCR ,  lysophospholipid
Research theme for competitive and other funds  (51)：
  • 2023 - 2027 Stratification of depression based on lysophospholipid metabolic disorders and innovative development of novel antidepressants
  • 2022 - 2025 Elucidation of immunoregulatory roles of lysophospholipid mediators and their pharmacological significance
  • 2020 - 2023 多種多様な脂肪酸種で構成されるリン脂質分子種の意義解明
  • 2019 - 2022 Identification of synthetic pathway for lysophosphatidylserine in activated lymphocytes.
  • 2015 - 2020 Analyses of membrane phospholipid quality
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Papers (489)：
  • Makoto Ohira, Akiharu Uwamizu, Keita Hori, Yumi Obinata, Daisuke Uta, Junken Aoki, Keiichi Ebina, Tsukasa Matsumoto, Akira Sato. Biotinylated Heptapeptides with D-amino Acids Suppress Allergic Reactions by Inhibiting Mast Cell Activation and Antagonizing the Histamine Receptor. International Journal of Peptide Research and Therapeutics. 2024. 31. 1
  • Sazanami Mori, Natsuki Nakamura, Ayane Fuchigami, Satoshi Yoshimoto, Moe Sakakibara, Toshiyuki Ozawa, Junken Aoki, Asuka Inoue, Hayakazu Sumida, Hideya Ando, et al. Intracellular TAS2Rs act as a gatekeeper for the excretion of harmful substances via ABCB1 in keratinocytes. FASEB BioAdvances. 2024
  • Taiga Iwama, Kuniyuki Kano, Hiroki Kawana, Hideo Shindou, Takao Shimizu, Nozomu Kono, Junken Aoki. Visualization of Phospholipid Synthesis on Tissue Sections Using Functional Mass Spectrometry Imaging. Analytical chemistry. 2024. 96. 29. 11771-11779
  • Yoshinori Takano, Hiroshi Naraoka, Jason P. Dworkin, Toshiki Koga, Kazunori Sasaki, Hajime Sato, Yasuhiro Oba, Nanako O. Ogawa, Toshihiro Yoshimura, Kenji Hamase, et al. Primordial aqueous alteration recorded in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu. Nature Communications. 2024. 15. 1
  • Mary P Moore, Xiaobo Wang, John Paul Kennelly, Hongxue Shi, Yuki Ishino, Kuniyuki Kano, Junken Aoki, Alessandro Cherubini, Luisa Ronzoni, Xiuqing Guo, et al. Low MBOAT7 expression, a genetic risk for MASH, promotes a pro-fibrotic pathway involving hepatocyte TAZ upregulation. Hepatology (Baltimore, Md.). 2024
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MISC (659)：
  • 片岡陸汰, 川名裕己, 佐藤悠喜飛, 可野邦行, 河野望, 青木淳賢. リン脂質sn-1位脂肪酸導入酵素としてのLPLAT10/LPEAT2の機能解析. 次世代を担う若手のためのファーマ・バイオフォーラム講演要旨集. 2023. 22nd
  • 岩田紘歩, 坂本新悟, 川名裕己, 河野望, 青木淳賢. THP-1細胞分化に伴うリン脂質脂肪酸鎖リモデリングを担う分子の探索. 日本生化学会大会(Web). 2023. 96th
  • 高鳥翔, 惠谷隼, 近江純平, 斉藤貴志, 西道隆臣, 高井俊行, 大和田智彦, 青木淳賢, 富田泰輔. ミクログリアによるアミロイドβ貪食の分子機構とその制御. Dementia Japan. 2023. 37. 4
  • 惠谷隼, 高鳥翔, 赤堀愛果, 近江純平, 青木淳賢, 大和田智彦, 渡部博貴, 岡野栄之, 富田泰輔. GPR34選択的アゴニストはミクログリアにおけるアミロイドβ線維の貪食を促進する. 日本生化学会大会(Web). 2023. 96th
  • 梶谷直人, 梶谷直人, 梶谷直人, 岡田麻美, 井上飛鳥, 朴秀賢, 青木淳賢, 竹林実, 竹林実. Tricyclic antidepressants act as a G protein-biased LPA1 receptor agonist and contribute to antidepressant effects. 日本生物学的精神医学会(Web). 2023. 45th
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Professional career (1)：
  • 薬学博士 (The University of Tokyo)
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