Rchr
J-GLOBAL ID：200901055052709714   Update date: Oct. 19, 2024

Taniguchi Naoyuki

谷口 直之 | Taniguchi Naoyuki
Affiliation and department：
Osaka International Cancer Institute Department of Glyco-Oncology and Medical Biochemistry

About Osaka International Cancer Institute Department of Glyco-Oncology and Medical Biochemistry


Job title： Director of Research Center and Chair of Department of Glyco-Oncology and Medical Biochemistry
Homepage URL  (2)： https://oici.jp/laboratory/outline/gaiyou/ ,  https://oici.jp.e.abv.hp.transer.com/laboratory/outline/gaiyou/
Research field  (1)： Pathobiochemistry
Research keywords  (12)： Glycoscience ,  Glycogenes and their regulation ,  Glyco-redox ,  Glycosyltransferases in Volvo’s in N-glycan brabching ,  Metabolism of reactive oxygen species ,  Glutathione metabolism ,  Glycation of protein ,  Complex carbohydrates (Glycoconjugates) ,  Disease Glycomics ,  Glycation of Proteins ,  Reactive Oxygen Species and its Metabolism ,  Glycobiology
Research theme for competitive and other funds  (75)：
  • 2018 - 2021 Modulation of cancer cells by core fucose-specific antibody
  • 2017 - 2020 Therapeutic effects of keratan sulfate disaccharide and its analog against COPD
  • 2015 - 2019 Elucidation of pathological mechanisms by integration glycans and redox
  • 2014 - 2019 Oxygen biology: a new criterion for integrated understanding of life
  • 2015 - 2018 Development of novel glycan-based drug for cancer, COPD and Alzheimer's disease
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Papers (785)：
  • Naoyuki Taniguchi, Yuki Ohkawa, Taiki Kuribara, Junpei Abe, Yoichiro Harada, Motoko Takahashi. Roles of Glyco-redox in Epithelial Mesenchymal Transition and Mesenchymal Epithelial Transition, Cancer, and Various Diseases. Antioxidants & redox signaling. 2024
  • Emma Lee Johnson, Yuki Ohkawa, Noriko Kanto, Reiko Fujinawa, Taiki Kuribara, Eiji Miyoshi, Naoyuki Taniguchi. The S1 spike protein of SARS-CoV-2 upregulates the ERK/MAPK signaling pathway in DC-SIGN-expressing THP-1 cells. Cell stress & chaperones. 2024. 29. 2. 227-234
  • Tiantong Wang, Zhiwei Zhang, Changduo Qu, Wanli Song, Ming Li, Xiaoguang Shao, Tomohiko Fukuda, Jianguo Gu, Naoyuki Taniguchi, Wenzhe Li. Core fucosylation regulates the ovarian response via FSH receptor during follicular development. Journal of advanced research. 2024
  • Noriko Kanto, Yuki Ohkawa, Masato Kitano, Kento Maeda, Masafumi Shiida, Tatsuya Ono, Fumi Ota, Yasuhiko Kizuka, Kei Kunimasa, Kazumi Nishino, et al. A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2. The Journal of biological chemistry. 2023. 299. 12. 105365-105365
  • Noriko Kanto, Yuki Ohkawa, Masato Kitano, Kento Maeda, Masafumi Shiida, Tatsuya Ono, Fumi Ota, Yasuhiko Kizuka, Kei Kunimasa, Kazumi Nishino, et al. A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2. The Journal of biological chemistry. 2023. 299. 12. 105365-105365
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MISC (806)：
  • 谷口 直之. 非酵素的糖化反応(メイラード反応)の疾患における役割と今後の展望(5)疾患におけるMaillard反応と今後の展望 グリケーションとグリコシレーションが関わる酸化的ストレスとアルツハイマー病. BIO Clinica. 2022. 37. 13. 1193-1198
  • 前田 賢人, 原田 陽一郎, 大川 祐樹, 谷口 直之. N-アセチルグルコサミン転移酵素Vは肺がん細胞において抗がん剤ゲフィチニブ耐性を誘導する. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1T02a-05
  • 大川 祐樹, 木塚 康彦, 高田 美咲, 中の 三弥子, 伊藤 恵美, Mishra Sushil K., 赤塚 晴奈, 前田 賢人, 原田 陽一郎, 谷口 直之. グライコプロテオミクスによる糖転移酵素GnT-IIIのタンパク質認識機構の解析. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3T02a-07
  • 井原 秀之, 岡田 貴裕, 谷口 直之, 池田 義孝. ヒトα1,6-フコース転移酵素(FUT8)の酵素活性に影響を及ぼすα-ヘリカル(コイルドコイル)ドメイン内疎水性アミノ酸残基の探索. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 2P-029
  • 前田 賢人, 原田 陽一郎, 大川 祐樹, 谷口 直之. N型糖鎖修飾の阻害はヒト非小細胞肺がん株PC-9のゲフィチニブ耐性機構をMET遺伝子増幅に収束させる(Targeting N-glycosylation converges the gefitinib resistance mechanism to MET amplification in human NSCLC PC-9 cells). 日本癌学会総会記事. 2022. 81回. J-2028
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Patents (99)：
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Books (112)：
  • 糖鎖を標的とした肺がん、およびその全判病変の診断・治療法の開発をめざして
    ダイアローグ株式会社 2022
  • Glycoscience : basic science to applications : insights from the Japan consortium for glycobiology and glycotechnology (JCGG)
    Springer 2019 ISBN:9789811358555
  • Medical Biochemistry With STUDENT CONSULT online access 4e(Medical Biochemistry)
    Elsevier Japan, Maruzen Publishing (Sales) 2018 ISBN:9784621301692
  • Essentials of Glycobiology 3rd Edition
    Cold Spring Harbor Laboratory Press 2017 ISBN:9781621821328
  • Glycoscience : biology and medicine
    Springer 2015 ISBN:9784431548409
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Lectures and oral presentations  (82)：
  • Expectations for JHUPO: Lessons from the Human Disease Glycomics Initiative (HGPI)
    (JHUPO 2021)
  • Branching N-glycans and their roles in disease onset, biomarker discovery and treatment.
    (GlycoBioTec 2019 2019)
  • Role of branched N-glycans in disease
    (International Polysaccharide Reserach Center opening Ceremony/Seminar 2018)
  • Branching N-glycans in disease onset, biomarker discovery and therapeutics.
    (1st Academic Seminar of IPRC & IGRC 2018)
  • Branching N-glycans and diseases: approach from biochemistry to systems glycobiology.
    (2018 Annual Meeting of the Society for Glycobiology 2018)
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Education (7)：
  • 1972 - 1973 Hokkaido University School of Medicine Department of Biochemistry
  • 1968 - 1972 Hokkaido University Graduate School of Medicine The 1st Department of Biochemistry
  • 1970 - 1970 Osaka University Institute for Protein Research Department of Enzyme
  • 1967 - 1968 Hokkaido University Hokkaido University Hospital Internship
  • 1963 - 1967 Hokkaido University Faculty of Medicine Medical School
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Professional career (1)：
  • Doctor of Medical Science,(equivalent for PhD) (Hokkaido University)
Work history (21)：
  • 2019/04 - 現在 Osaka International Cancer Institute Research Center Director of Research Center and Chair of the Department of Glyco-Oncology (concurrent duties)
  • 2018/04 - 現在 Osaka International Cancer Institute RGlyco-Oncology Glyco-Oncology Department of Glyco-Oncology Department head
  • 2006/04 - 現在 Osaka University Professor Emeritus
  • 2024/04 - Osaka International Cancer Institute Department of Glyco-Oncology and Medical Biochemsityr Directoer of Research Instituet and Chair
  • 2024/04 - RIKEN Honarable fellow
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Committee career (44)：
  • 2019/04 - 現在 Sapporo Cancer Seminar Foundation Councilor, vice-chair
  • 2019/01 - 現在 Sapporo Cancer Seminar Foundation Vice-Chairman of the Board of Trustees
  • 2007 - 現在 UBMB Life Editorial board member
  • 2007/01 - 現在 Japanese Biochemical Society, Japanese Cancer Association , Japanese Society for Carbohydrate Reseaach Honorary member
  • 2005/01 - 現在 Proteomics Clinical Applications Senior Editor
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Awards (16)：
  • 2018/10 - Society for Glycobiology (US) Karl Meyer Lectureship Award Lessons from glycosyltransferase genes invovled in the branching of N-glycans
  • 2016 - The Order o the Sacred Treasure, Gold Rays with Neck Ribbon
  • 2011 - Japan Academy Prize
  • 2010/10 - WILEY BLackWELL The FEBS Journal Top-Cited Paper Award Branched N-glycans regulate the biological functions of integrins and cadherins
  • 2010/04 - Northeastern University. Barnette Lectureship Why is Sweet Science Important?
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Association Membership(s) (15)：
JHUPO Honorary member ,  Humsn Pfoteome Organization ,  日本糖質学会 ,  日本医学会 ,  日本電気泳動学会 ,  国際糖鎖生物学会 ,  アメリカ生化学会・分子生物学会 ,  日本NO学会 ,  アメリカ化学会 ,  日本糖尿病学会 ,  日本臨床化学会 ,  New York Academy of Science ,  (アメリカ癌学会)American Association for Cancer Research ,  日本癌学会 ,  日本生化学会
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