Rchr
J-GLOBAL ID:200901055306904156
Update date: Feb. 13, 2025
Ishiwata Toshiyuki
イシワタ トシユキ | Ishiwata Toshiyuki
Affiliation and department:
Homepage URL (2):
https://ttaggg-rtgp.org/
,
http://www.tmig.or.jp/eresearch/a21.html
Research field (5):
Digestive surgery
, Gastroenterology
, Experimental pathology
, Human pathology
, Molecular biology
Research keywords (13):
3-dimensional culture
, Cellular senescence
, Epithelial-mesenchymal transition
, 膵臓癌
, 線維芽細胞増殖因子
, nestin
, 糖鎖
, 細胞外基質
, 癌幹細胞
, 細胞増殖因子受容体
, 消化器癌
, Molecular biology
, Experimental Pathology
Research theme for competitive and other funds (36):
- 2024 - 2027 3次元培養を用いた膵臓がん細胞のプロテオーム解析:個別化治療と早期診断法の探索
- 2022 - 2025 高齢者胃癌の遺伝子異常に基づく病態解明と治療戦略
- 2022 - 2025 Molecular biological analysis of gastrointestinal neuroendocrine tumors and development of new therapeutic drugs
- 2022 - 2025 Development of novel therapies by regulating epithelial and mesenchymal features of pancreatic cancer
- 2021 - 2025 幹細胞表面特異的糖鎖を標的とした膵癌の新規治療法の開発
- 2021 - 2024 New therapeutic methods by variability control of pancreatic cancer cells
- 2023 - 2024 膵癌の老化誘導薬の探索と老化細胞死誘導の研究
- 2021 - 2022 膵臓がん細胞の老化誘導と老化細胞除去療法の開発
- 2019 - 2022 Development of early diagnosis and new treatments for pancreatic cancer using cancer stem cell-specific glycans
- 2021 - 2022 スフェア形成法を用いた膵癌幹細胞に有効な薬剤の探索
- 2019 - 2020 スフェア形成法を用いた膵癌幹細胞に有効な薬剤の探索
- 2016 - 2019 Mechanisms of aging in the tissue progenitor cells and tissue regeneration
- 2016 - 2019 新たな膵癌分子標的のFGFR-4に対する個別化治療の研究
- 2014 - 2017 The biological role and signal pathway of Stat5 in pancreatic cancer
- 2014 - 2017 Basic study of a long non-coding RNA, H19, as a novel therapeutic target for pancreatic cancer
- 2014 - 2017 犬の難治性がんにおける癌幹細胞の特性解析と癌幹細胞標的治療法の基盤構築
- 2013 - 2016 Regulation of nestin using microRNA: Examination for clinical application of pancreatic cancer therapy
- 2013 - 2016 Inhibition of nestin phosphorylation in pancreatic cancer cells
- 2011 - 2013 Identification of Pancreatic Cancer Stem Cells and Development of Novel Therapeutic Strategies using Stem Cell Markers
- 2010 - 2012 Treatment strategy of pancreatic cancer by regulating FGFR2IIIc isoform
- 2008 - 2010 Investigation of differentiation of extrapancreatic stem cells to pancreatic β-cells
- 2007 - 2008 Novel strategy for pancreatic cancer treatment, using keratinocyte growth factor receptor
- 2006 - 2007 Ideniification and isolation of pancreatic stem cells
- 2006 - 2007 Inhibitory effect of lumican on the growth factor-mediated pancreatic cancer cell growth
- 2005 - 2006 Role of lumican for cell growth and differentiation in pancreatic cancer
- 2004 - 2005 Identification and application of pancreatic internal and external progenitor cell having differentiation potency to β-cells
- 2003 - 2004 Role of lumican in pancreatic cancer and chronic pancreatits-like lesion in pancreatic cancer
- 2003 - 2004 Research of pancreatic regeneration by fibroblast growth factor -7 and -10
- 2001 - 2002 Expression and the role of fibroblast growth factor (FGF)-10 in chronic pancreatitis
- 1998 - 1999 関節リウマチのサイトカインおよび血管増殖因子抑制効果に関する基礎的研究-サイトカインおよびVEGFアンチセンス療法による新しい治療戦略-
- 膵臓癌における癌幹細胞の研究
- 膵臓癌および大腸癌におけるルミカンの研究
- 膵臓癌における増殖因子の分子病理学的研究
- Pancreatic cancer stem cell
- Role of Lumican on pancreatic or colorectal cancer
- Molecular Pathological study of growth factors on pancreatic cancer
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Papers (246):
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Seiichi Shinji, Yutaro Ogawa, Takeshi Yamada, Akihisa Matsuda, Kay Uehara, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Toshimitsu Miyasaka, Shintaro Kanaka, et al. Morphological and functional analysis of colorectal cancer cell lines in 2D and 3D culture models. Scientific reports. 2025. 15. 1. 3047-3047
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Takashi Nakano, Kouki Okita, Shogo Okazaki, Soshi Yoshimoto, Sachiko Masuko, Hideki Yagi, Kazunori Kato, Yoshihisa Tomioka, Kenichi Imai, Yoichi Hamada, et al. CD44v, S1PR1, HER3, MET and cancer-associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb. FEBS open bio. 2025
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Keisuke Nonaka, Junko Aida, Yasuko Hasegawa, Tomio Arai, Toshiyuki Ishiwata, Kaiyo Takubo. Telomere Length Measurement in Human Tissue Sections by Quantitative Fluorescence In Situ Hybridization (Q-FISH). Methods in Molecular Biology. 2024. 9-14
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Keisuke Nonaka, Akira Arakawa, Manato Hara, Akiko Komatsu, Takuya Nagasaka, Toshio Kumasaka, Seiya Kamino, Hirofumi Rokutan, Yuuki Shichi, Shigeo Murayama, et al. An Autopsy Case of Myotonic Dystrophy Type 1 With Pancreatic Intraductal Papillary Mucinous Neoplasm. Cureus. 2024
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Yuuki Shichi, Fujiya Gomi, Yasuko Hasegawa, Keisuke Nonaka, Seiichi Shinji, Kimimasa Takahashi, Toshiyuki Ishiwata. Artificial intelligence-based analysis of time-lapse images of sphere formation and process of plate adhesion and spread of pancreatic cancer cells. Frontiers in Cell and Developmental Biology. 2023. 11
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MISC (697):
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進士誠一, 進士誠一, 志智優樹, 山田岳史, 松田明久, 上原圭, 横山康行, 高橋吾郎, 岩井拓磨, 武田幸樹, et al. Morphofunctional analysis of human colon cancer cell lines in 3D culture. 日本癌学会学術総会抄録集(Web). 2023. 82nd
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石渡俊行. 加齢とがん. 保健の科学. 2022. 64. 8. 526-530
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佐々木 紀彦, 石渡 俊行. 膵癌特異的ガングリオシドに対する光免疫療法の適用. 大和証券ヘルス財団研究業績集. 2022. 45. 54-57
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相田 順子, 田久保 海誉, 石渡 俊行. 【ここが知りたい、表在型Barrett食道腺癌】Barrett食道・Barrett食道腺癌の病理判定基準 欧米と本邦ではどのくらい違うのか. 消化器内視鏡. 2021. 33. 11. 1659-1668
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佐々木 紀彦, 五味 不二也, 吉村 久志, 山本 昌美, 松田 陽子, 道下 正貴, 畠山 仁, 川野 陽一, 板倉 陽子, 豊田 雅士, et al. FGFR4阻害剤のBLU9931により、膵癌細胞で細胞老化が誘導される. 日本癌学会総会記事. 2021. 80回. [J16-6]
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Patents (2):
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膵臓がんの診断補助方法及び膵臓がん治療用医薬組成物
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医薬組成物
Books (8):
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図解 病理解剖ガイド 新井冨生編集
文光堂 2018
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Evolution of the molecular biology of brain tumors and the therapeutic implications.
InTech 2013
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Encyclopedia of cancer
Springer 2012
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Brain tumors/Book 2
In Tech 2012
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"Immunohistochemical and in situ hybridization analysis of lumican in colorectal carcinoma" in Handbook of immunohistochemical and in situ hybridization of human carcinomas, Vol. 2: Molecular Pathology, Colorectal carcinoma,& Prostatic・・・
Elseveier Academic Press 2005
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Lectures and oral presentations (149):
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分子形態学が挑む膵癌研究ー受容体から癌幹細胞、多様性研究へー
(2024)
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Induction of cellular senescence in pancreatic cancer cells
(The 83rd Annual Meeting of the Japanese Cancer Association 2024)
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3次元培養による膵癌培養細胞株の形態的、機能的多様性の解析
(第55回日本膵臓学会大会 2024)
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Telomere and the cancer (pancreatic cancer) in senior citizens
(2024)
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個別化治療を目指した、膵がんの幹細胞と多様性の研究
(金沢大学がん進展制御研究所第4回腫瘍制御共同研究セミナー 2024)
more...
Education (1):
- - 1986 Kawasaki Medical School School of Medicine Department of Medicine
Professional career (1):
- M.D.,Ph.D. (Nippon Medical School)
Work history (7):
- 2020/04 - 現在 東京農工大学 非常勤講師
- 2016/01 - 現在 Tokyo Metropolitan Institute of Gerontology Division of Aging and Carcinogenesis Director
- 2010/04 - 現在 女子栄養大学 非常勤講師
- 2004 - 2015/12 Nippon Medical School Medical School
- 2000 - 2003 Nippon Medical School Medical School
- 1988 - 2000 Nippon Medical School Medical School
- 1995 - 1998 カリフォルニア大学アーバイン校留学 内分泌、代謝、糖尿病学教室 (Murray Korc教授)
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Committee career (18):
- 2019 - 現在 日本癌学会 評議員
- 2017 - 現在 日本膵臓学会 評議員
- 2015 - 現在 日本病理学会 学術評議員
- 2011 - Editorial Board member: Insight Cancer Research
- 2011 - Editorial Board member: Gastroenterology and Hepatology Research
- 2011 - Editorial Board member: Gastroenterology and Hepatology
- 2011 - Editorial Board member: Journal of Carcinogenesis and Mutagenesis
- 2011 - Editorial Board member: Journal of Gastroenterology and Hepatology Research
- 2011 - Editorial Board member: Gastroenterology and Hepatology
- 2010 - Editorial Board member:Journal of carcinogenesis and mutagenesis
- 2010 - Editorial Board member: World Journal of Gastroenterology
- 2010 - Editorial Board member: World Journal of Gastroenterology
- 2009 - Editorial Board member: Oncology Letters
- 2009 - Editorial Board member: Journal of Oncology
- 2009 - Editorial Board member: Oncology Letters
- 2009 - Editorial Board member: Journal of Oncology
- 平成28年度~29年度 独立行政法人 日本学術振興会 科学研究費 第一段審査(書面審査)委員、消化器内科学
- 平成30年度~令和2年度 独立行政法人 日本学術振興会 科学研究費委員会専門委員、2段階書面審査 若手研究、消化器外科学関連、55020(小区分)
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Awards (7):
- 2024/09 - https://topresearcherslist.com/Home/Profile/910379 https://topresearcherslist.com/Home/Profile/910379
- 2022/03 - Scientific Reports Top 100 in Cancer 2021: https://www.nature.com/articles/s41598-021-86028-1
- 2018 - Pathology International High Citation Award 2018: Cancer stem cells and epithelial-mesenchymal transition: Novel therapeutic targets for cancer.
- 2015 - 日本病理学会学術研究賞(A演説) :「癌幹細胞と上皮間葉転換を標的とした革新的な癌治療法」
- 2015 - PanCAN Best Basic Research Award(第46回日本膵臓学会大会) :「膵癌における線維芽細胞増殖因子受容体(FGFR-4)発現と治療標的としての可能性」
- 2002 - 日本医科大学医学会奨学賞 :「線維芽細胞増殖因子(FGF)ファミリーの消化器疾患における分子病理学的検討」
- 1992 - 日本医科大学同窓会賞 :「血管新生病の進展制御に関する分子病理学的研究」
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Association Membership(s) (7):
American Association for Cancer Research
, International Association of Pancreatology
, American Pancreatic Association
, 日本癌学会
, 日本病理学会
, 日本老年医学会
, 日本膵臓学会
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