Research theme for competitive and other funds (55):
2009 - 2014 Characterization of structural dynamics of intrinsically disordered proteins
2009 - 2014 Integrative understanding of biological processes mediated by transient macromolecul ar complexes; New technology for visualizing physiologically metastable states
2009 - 2014 Target recognition and expression mechanism of intrinsically disordered protein
2008 - 2012 Dynamics of intrinsically disordered proteins and their functional roles
2003 - 2009 Molecular soft interactions regulating membrane-interface activities in living systems
2008 - 2008 核内転写関連因子の天然変性状態と動的構造解析
2007 - 2008 ソフトな相互作用からなる、塩濃度に敏感な複合体の溶液構造の解析
2005 - 2007 Basic research on double-stranded DNA-binding proteins
1994 - 1998 Analyses of Signal Transduction Mechanisms based on Protein Structures
1997 - 1997 構造生物学にもとづくシグナル伝達機構の解明
1994 - 1997 Roles of Protein Structures on the DNA Recognition
1994 - 1996 Information Exchange on Cancer Research with North American
1993 - 1994 生体高分子用レーザー増感NMR装置の製作
1993 - 1993 蛋白質の高次構造に基づくシグナル認識機構の解明
1993 - 1993 DNAの高次構造を識別する蛋白質(まとめ)
1993 - 1993 特異な構造をもつヌクレオシドの化学合成と反応
1992 - 1992 遺伝子調節機構の立体構造とダイナミクスの研究調査
1992 - 1992 蛋白質が認識するDNA構造
1991 - 1991 蛋白質が認識するDNA構造
1991 - 1991 DNAの高次講造を識別する蛋白質
1990 - 1990 蛋白質が認識するDNA構造
1990 - 1990 DNAの高次構造を識別する蛋白質
1989 - 1989 Pー450の活性部位構造の解析
1989 - 1989 DNAの高次構造を識別する蛋白質
1988 - 1989 DNAの曲がりとタンパク質による認識の構造的基盤
1988 - 1989 Structure and Functions of Immunoglobulins
1987 - 1989 Design of a high-resolution NMR spectrometer for in vivo measurements
1988 - 1988 P-450の活性部位構造の解析と細胞内P-450の構造的同定
1988 - 1988 発現調節の分子論的解析
1987 - 1988 走査型レーザ顕微ラマン分光システムの製作
1987 - 1988 Structures and Reactivities of Higher-valent Reaction Intermediates of Heme-containing Enzymes
1986 - 1987 塩基配列に依存した溶液中のDNA構造と制限酵素による識別
1986 - 1987 Versatality of Nucleic Acid Structure and its recognition
染色体末端テロメアの構造解析
蛋白質・DNA複合体の構造解析
シグナル認識タンパク質の構造解析
Structural Analyses of Telomeres
Structural Analyses of DNA・Protein Complexes
Structural Analyses of Signal-Recognizing Proteins
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Papers (82):
Masahiko Okuda, Yoshifumi Nishimura. Structural polymorphism of the PH domain in TFIIH. Bioscience Reports. 2023. 43. 7
Hideaki Ohtomo, Tsutomu Yamane, Takashi Oda, Noriyuki Kodera, Jun-ichi Kurita, Yasuo Tsunaka, Romain Amyot, Mitsunori Ikeguchi, Yoshifumi Nishimura. Dynamic solution structures of whole human NAP1 dimer bound to one and two histone H2A-H2B heterodimers obtained by integrative methods. Journal of Molecular Biology. 2023. 168189-168189
Hideaki Ohtomo, Shinsuke Ito, Nicholas J. McKenzie, Michael Uckelmann, Masatoshi Wakamori, Haruhiko Ehara, Ayako Furukawa, Yasuo Tsunaka, Marika Shibata, Shun-ichi Sekine, et al. H2A ubiquitination alters H3-tail dynamics on linker-DNA to enhance H3K27 methylation. Journal of Molecular Biology. 2023. 435. 4. 167936-167936
Masahiko Okuda, Yasuo Tsunaka, Yoshifumi Nishimura. Dynamic structures of intrinsically disordered proteins related to the general transcription factor TFIIH, nucleosomes, and histone chaperones. Biophysical Reviews. 2022. 14. 6. 1449-1472
Yasuo Tsunaka, Hideaki Ohtomo, Yoshifumi Nishimura. FACT modulates the conformations of histone H2A and H2B N-terminal tails within nucleosomes. Communications biology. 2022. 5. 1. 814-814