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J-GLOBAL ID：200901055438493007   Update date: Apr. 17, 2024

Miyazono Kohei

ミヤゾノ コウヘイ | Miyazono Kohei
Affiliation and department：
The University of Tokyo Graduate School of Medicine, Pathology, Immunology and Microbiology, Department of Molecular Pathology

About The University of Tokyo Graduate School of Medicine, Pathology, Immunology and Microbiology, Department of Molecular Pathology


Job title： Professor
Homepage URL  (1)： http://beta-lab.umin.ac.jp
Research field  (4)： Tumor biology ,  Experimental pathology ,  Pathobiochemistry ,  Medical biochemistry
Research keywords  (7)： 腫瘍生物学 ,  実験病理学 ,  病態医化学 ,  医化学一般 ,  Cell Biology ,  Pathological Medical Chemistry ,  Medical Chemistry in General
Research theme for competitive and other funds  (59)：
  • 2020 - 2023 Comprehensive Studies on the Mechanisms of Cancer Metastasis from Molecular Signaling to Whole-Body Level
  • 2017 - 2022 Integrated analysis and regulation of cellular diversity
  • 2017 - 2022 Molecular mechanisms of cell differentiation and diversity by TGF-β family members
  • 2019 - 2021 ゲノム医療の実装に資する臨床ゲノム情報統合データベースの整備と我が国の継続的なゲノム医療実施体制の構築
  • 2018 - 2021 Development of Novel ALK2 Inhibitor for FOP
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Papers (178)：
  • Kei Takahashi-Yamashiro, Kohei Miyazono. Tissue clearing method in visualization of cancer progression and metastasis. Upsala Journal of Medical Sciences. 2024. 129
  • Shiori Tokizaki, Katarzyna A. Podyma-Inoue, Takehisa Matsumoto, Kazuki Takahashi, Miho Kobayashi, Haruka Ibi, Shizuka Uchida, Sadahiro Iwabuchi, Hiroyuki Harada, Shinichi Hashimoto, et al. Inhibition of transforming growth factor-β signals suppresses tumor formation by regulation of tumor microenvironment networks. Cancer Science. 2023
  • Kei Takahashi, Ko Abe, Shimpei I Kubota, Noriaki Fukatsu, Yasuyuki Morishita, Yasuhiro Yoshimatsu, Satoshi Hirakawa, Yoshiaki Kubota, Tetsuro Watabe, Shogo Ehata, et al. An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis. Nature communications. 2022. 13. 1. 5239-5239
  • Kazuki Takahashi, Katarzyna A. Podyma-Inoue, Maki Saito, Shintaro Sakakitani, Akinari Sugauchi, Keita Iida, Sadahiro Iwabuchi, Daizo Koinuma, Kyoko Kurioka, Toru Konishi, et al. TGF-β generates a population of cancer cells residing in G1 phase with high motility and metastatic potential via KRTAP2-3. Cell Reports. 2022. 40. 13. 111411-111411
  • Jun Nishida, Kosuke Miyakuni, Kohei Miyazono, Shogo Ehata. An in vivo orthotopic serial passaging model for a metastatic renal cancer study. STAR protocols. 2022. 3. 2. 101306-101306
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MISC (132)：
  • 井上 カタジナアンナ, 高橋 和樹, 須河内 昭成, 飯田 渓太, 岩淵 禎弘, 鯉沼 代造, 栗岡 恭子, 小西 徹, 田中 晋, 戒田 篤志, et al. がん研究における女性研究者 TGF-βは増殖が低下して運動能が上昇したがん細胞集団を形成することで口腔がんの転移を亢進する(TGF-β enhances metastasis of oral cancer via generation of a population of cancer cells in G1 phase with high motility). 日本癌学会総会記事. 2022. 81回. SS1-5
  • Kazuki Takahashi, Katarzyna A. Inoue, Shintaro Sakakitani, Toru Konisi, Akinari Sugauchi, Maki Saito, Atsushi Kaida, Daizo Koinuma, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, et al. Oral cancer cells under TGF-beta-induced cell cycle arrest exhibit motile phenotypes through induction of EMT. CANCER SCIENCE. 2022. 113. 910-910
  • 鯉沼代造, 田村佑介, 森川真大, 森川真大, 堤修一, 田邉諒, 田邉諒, 宮園浩平, 宮園浩平. PolyI:C attenuates TGF-β signaling to induce pyroptotic and cytostatic programs in triple-negative breast cancer. 日本癌学会学術総会抄録集(Web). 2022. 81st
  • 荻窪一貴, 西田純, 西田純, 高橋恵生, 高橋恵生, 森川真大, 森川真大, 江幡正悟, 江幡正悟, 鯉沼代造, et al. Identification of the mechanisms of malignant progression of triple-negative breast cancer via epigenetic changes. 日本癌学会学術総会抄録集(Web). 2022. 81st
  • 高橋 和樹, 井上 カタジナアンナ, 榊谷 振太郎, 小西 徹, 須河内 昭成, 齋藤 万樹, 戒田 篤志, 鯉沼 代造, 吉松 康裕, 内橋 俊大, et al. TGF-βにより細胞周期が静止した口腔扁平上皮がん細胞は上皮間葉移行の誘導を介して運動・転移能が亢進する. 日本癌学会総会記事. 2021. 80回. [J13-6]
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Books (2)：
  • The Biology of the TGF-β Family
    Cold Spring Harbor Perspectives in Biology 2017
  • The TGF-β Family
    Cold Spring Harbor Laboratory Press 2008
Education (2)：
  • - 1981 The University of Tokyo Faculty of Medicine School of Medicine
  • - 1981 The University of Tokyo Faculty of Medicine
Professional career (1)：
  • M.D., Ph.D.
Work history (6)：
  • 2000/08 - 現在 The University of Tokyo Graduate School of Medicine Professor
  • 2019/04 - 2021/03 The University of Tokyo Executive Vice President
  • 2011/04 - 2019/03 The University of Tokyo Graduate School of Medicine Dean
  • 1995/04 - 2000/07 Japanese Foundation for Cancer Research (JFCR) Department of Biochemistry, The Cancer Institute Chief
  • 1990/02 - 1995/03 Uppsala University, Sweden Ludwig Institute for Cancer Research Researcher
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Awards (12)：
  • 2019/11 - Princess Takamatsu Cancer Research Fund Nakahara Memorial Lecture Prize
  • 2018 - The Japan Academy Member
  • 2018 - Japanese Cancer Association The Tomizo Yoshida Prize
  • 2012 - AAAS (American Association for the Advancement of Science) Fellow
  • 2011 - Japan Academy Prize
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Association Membership(s) (9)：
The Japanese Vascular Biology and Medicine Organization ,  The Japanese Association for Molecular Target Therapy of Cancer ,  The Molecular Biology Society of Japan ,  Japanese Biochemical Society ,  Japanese Cancer Association ,  American Association for the Advancement of Science (AAAS) ,  American Association for Cancer Research (AACR) ,  The Japanese Association for Metastasis Research ,  The Japanese Society of Pathology
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