Rchr
J-GLOBAL ID：200901055438493007   Update date: Nov. 18, 2024

Miyazono Kohei

ミヤゾノ コウヘイ | Miyazono Kohei
Affiliation and department：
The University of Tokyo Graduate School of Medicine, Pathology, Immunology and Microbiology, Department of Molecular Pathology

About The University of Tokyo Graduate School of Medicine, Pathology, Immunology and Microbiology, Department of Molecular Pathology


Job title： Professor
Homepage URL  (1)： http://beta-lab.umin.ac.jp
Research field  (4)： Tumor biology ,  Experimental pathology ,  Pathobiochemistry ,  Medical biochemistry
Research keywords  (7)： 腫瘍生物学 ,  実験病理学 ,  病態医化学 ,  医化学一般 ,  Cell Biology ,  Pathological Medical Chemistry ,  Medical Chemistry in General
Research theme for competitive and other funds  (59)：
  • 2020 - 2023 Comprehensive Studies on the Mechanisms of Cancer Metastasis from Molecular Signaling to Whole-Body Level
  • 2017 - 2022 Integrated analysis and regulation of cellular diversity
  • 2017 - 2022 Molecular mechanisms of cell differentiation and diversity by TGF-β family members
  • 2019 - 2021 ゲノム医療の実装に資する臨床ゲノム情報統合データベースの整備と我が国の継続的なゲノム医療実施体制の構築
  • 2018 - 2021 Development of Novel ALK2 Inhibitor for FOP
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Papers (182)：
  • Keiji Miyazawa, Yuka Itoh, Hao Fu, Kohei Miyazono. Receptor-activated transcription factors and beyond: multiple modes of Smad2/3-dependent transmission of TGF-β signaling. Journal of Biological Chemistry. 2024. 300. 5. 107256-107256
  • Kei Takahashi-Yamashiro, Kohei Miyazono. Tissue clearing method in visualization of cancer progression and metastasis. Upsala Journal of Medical Sciences. 2024. 129
  • Shiori Tokizaki, Katarzyna A. Podyma-Inoue, Takehisa Matsumoto, Kazuki Takahashi, Miho Kobayashi, Haruka Ibi, Shizuka Uchida, Sadahiro Iwabuchi, Hiroyuki Harada, Shinichi Hashimoto, et al. Inhibition of transforming growth factor-β signals suppresses tumor formation by regulation of tumor microenvironment networks. Cancer Science. 2023
  • 荻窪 一貴, 西田 純, 高橋 恵生, 森川 真大, 江幡 正悟, 鯉沼 代造, 宮園 浩平. エピゲノム変化を介したトリプルネガティブ乳がん高悪性化機構の解明(Elucidation of the mechanisms of epigenetic change-mediated malignant transformation of triple-negative breast cancer). 日本癌学会総会記事. 2023. 82回. 1604-1604
  • Kei Takahashi, Ko Abe, Shimpei I Kubota, Noriaki Fukatsu, Yasuyuki Morishita, Yasuhiro Yoshimatsu, Satoshi Hirakawa, Yoshiaki Kubota, Tetsuro Watabe, Shogo Ehata, et al. An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis. Nature communications. 2022. 13. 1. 5239-5239
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MISC (138)：
  • 時崎 詩織, 井上 カタジナアンナ, 高橋 和樹, 小林 美穂, 松本 武久, 白水 美香子, 内田 靖哉, 岩淵 禎弘, 橋本 真一, 原田 浩之, et al. TGF-βシグナルの阻害はがん微小環境ネットワークを制御することで腫瘍形成を抑制する(Inhibition of TGF-β signaling suppresses tumorigenesis by regulating tumor microenvironment networks). 日本癌学会総会記事. 2023. 82回. 470-470
  • 井上 カタジナアンナ, 高橋 和樹, 斎藤 万樹, 榊谷 振太郎, 飯田 渓太, 岩淵 禎弘, 鯉沼 代造, 小西 徹, 田中 晋, 戒田 篤志, et al. TGF-βは、Slug/HMGA2非依存性EMTの誘導を介して、G1期に停止したがん細胞に高い運動性と転移能を与える(TGF-β confers cancer cells with the high motility and metastatic potential via induction of Slug/HMGA2-independent EMT). 日本癌学会総会記事. 2023. 82回. 1712-1712
  • 井上 カタジナアンナ, 高橋 和樹, 須河内 昭成, 飯田 渓太, 岩淵 禎弘, 鯉沼 代造, 栗岡 恭子, 小西 徹, 田中 晋, 戒田 篤志, et al. がん研究における女性研究者 TGF-βは増殖が低下して運動能が上昇したがん細胞集団を形成することで口腔がんの転移を亢進する(TGF-β enhances metastasis of oral cancer via generation of a population of cancer cells in G1 phase with high motility). 日本癌学会総会記事. 2022. 81回. SS1-5
  • 井上 カタジナアンナ, 高橋 和樹, 須河内 昭成, 飯田 渓太, 岩淵 禎弘, 鯉沼 代造, 栗岡 恭子, 小西 徹, 田中 晋, 戒田 篤志, et al. がん研究における女性研究者 TGF-βは増殖が低下して運動能が上昇したがん細胞集団を形成することで口腔がんの転移を亢進する(TGF-β enhances metastasis of oral cancer via generation of a population of cancer cells in G1 phase with high motility). 日本癌学会総会記事. 2022. 81回. SS1-5
  • Kazuki Takahashi, Katarzyna A. Inoue, Shintaro Sakakitani, Toru Konisi, Akinari Sugauchi, Maki Saito, Atsushi Kaida, Daizo Koinuma, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, et al. Oral cancer cells under TGF-beta-induced cell cycle arrest exhibit motile phenotypes through induction of EMT. CANCER SCIENCE. 2022. 113. 910-910
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Books (2)：
  • The Biology of the TGF-β Family
    Cold Spring Harbor Perspectives in Biology 2017
  • The TGF-β Family
    Cold Spring Harbor Laboratory Press 2008
Education (2)：
  • - 1981 The University of Tokyo Faculty of Medicine School of Medicine
  • - 1981 The University of Tokyo Faculty of Medicine
Professional career (1)：
  • M.D., Ph.D.
Work history (6)：
  • 2000/08 - 現在 The University of Tokyo Graduate School of Medicine Professor
  • 2019/04 - 2021/03 The University of Tokyo Executive Vice President
  • 2011/04 - 2019/03 The University of Tokyo Graduate School of Medicine Dean
  • 1995/04 - 2000/07 Japanese Foundation for Cancer Research (JFCR) Department of Biochemistry, The Cancer Institute Chief
  • 1990/02 - 1995/03 Uppsala University, Sweden Ludwig Institute for Cancer Research Researcher
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Awards (12)：
  • 2019/11 - Princess Takamatsu Cancer Research Fund Nakahara Memorial Lecture Prize
  • 2018 - The Japan Academy Member
  • 2018 - Japanese Cancer Association The Tomizo Yoshida Prize
  • 2012 - AAAS (American Association for the Advancement of Science) Fellow
  • 2011 - Japan Academy Prize
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Association Membership(s) (9)：
The Japanese Vascular Biology and Medicine Organization ,  The Japanese Association for Molecular Target Therapy of Cancer ,  The Molecular Biology Society of Japan ,  Japanese Biochemical Society ,  Japanese Cancer Association ,  American Association for the Advancement of Science (AAAS) ,  American Association for Cancer Research (AACR) ,  The Japanese Association for Metastasis Research ,  The Japanese Society of Pathology
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