Rchr
J-GLOBAL ID：200901055486447874
Update date: Nov. 19, 2024
Nakaoka Yoshikazu
ナカオカ ヨシカズ | Nakaoka Yoshikazu
Affiliation and department：
Job title：
Director/Deputy Director General of the Hospital
Research field (3)：
Cardiology
, Immunology
, Allergies and connective tissue disease
Research keywords (6)：
microbiota
, pulmonary hypertension
, Takayasu arteritis
, inflammation
, cardiovascular disaeses
, cytokine
Research theme for competitive and other funds (21)：
- 2023 - 2026 Construction of an evaluation system for feeding and swallowing disorders and sarcopenia after stroke and search for key molecules in the brain-gut-muscle linkage
- 2020 - 2025 高安動脈炎に関連する肺高血圧症に対するIL-6阻害薬の有効性と治療指標の探索
- 2020 - 2023 組織特異的AHRノックアウトマウスを用いた肺動脈性肺高血圧症発症メカニズムの解明
- 2020 - 2023 The Pathogenesis of pulmonary arterial hypertension via aryl hydrocarbon receptor
- 2019 - 2022 IL-6阻害による重症肺高血圧症の新規治療法開発に向けた基盤的研究
- 2017 - 2020 気管支上皮細胞のTrkBによる炎症性シグナルを介した肺高血圧症の病態機構の解明
- 2016 - 2019 Role of pulmonary sympathetic nerves in the regulation of the pulmonary circulation by beta-receptors on pulmonary macrophages during chronic intermittent hypoxia
- 2016 - 2019 Elucidation of the molecular pathogenesis of pulmonary hypertension via inflammatory cytokines
- 2015 - 2018 Biomarker research of peripartum cardiomyopathy with hypertensive disorders in pregnancy
- 2015 - 2017 Molecular mechanism of Vasculitis and Pulmonary arterial hypertension via inflammatory cytokines
- 2014 - 2017 Evaluation of cardiotoxicity and elucidation of cardiotoxic molecular mechanisms in cancer patients receiving angiogenesis inhibitors
- 2013 - 2016 Angiopoietin-1-mediated vascular development and maturation in the developing heart
- 2013 - 2015 The novel therapeutic strategy for pulmonary hypertension targeting inflammation amplification loop mediated by IL-6
- 2011 - 2014 Myocardial inflammation of heart failure as a novel therapeutic target
- 2011 - 2013 The molecular mechanism of atherosclerosis through endothelial dysfunction
- 2012 - 2012 The role of sarcomere-specific isoform of docking protein Gab1in heart failure
- 2009 - 2011 The signaling network between endothelium and myocardium responsible for myocardial protection
- 2007 - 2008 The role of paracrine signal networks between myocardium and endothelium in the prevention of heart failure
- 2005 - 2006 心血管系でのGabファミリー蛋白質の機能解析
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Papers (90)：
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Hideo Ohuchi, Ryotaro Asano, Aki Mori, Tomohiko Ishibashi, Daisuke Motooka, Michikazu Nakai, Yoshikazu Nakaoka. Gut Dysbiosis in Patients With Fontan Circulation. Journal of the American Heart Association. 2024. 13. 18. e034538
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Haruhito A. Uchida, Yoshikazu Nakaoka, Takahiko Sugihara, Hajime Yoshifuji, Yasuhiro Maejima, Yoshiko Watanabe, Hiroko Nagafuchi, Takahiro Okazaki, Yoshinori Komagata, Yoshiya Tanaka, et al. Clinical Characteristics and Treatment Outcomes of Patients With Newly Diagnosed Takayasu Arteritis in Japan During the First 2 Years of Treatment - A Nationwide Retrospective Cohort Study -. Circulation Journal. 2024
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Takako Miyamae, Yusuke Manabe, Takahiko Sugihara, Natsuka Umezawa, Hajime Yoshifuji, Naoto Tamura, Yoshiyuki Abe, Shunsuke Furuta, Hiroko Nagafuchi, Jun Ishizaki, et al. Pregnancy and childbirth in Takayasu arteritis in Japan: A nationwide retrospective study. Modern rheumatology. 2024
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Tomohiko Ishibashi, Tadakatsu Inagaki, Makoto Okazawa, Akiko Yamagishi, Keiko Ohta-Ogo, Ryotaro Asano, Takeshi Masaki, Yui Kotani, Xin Ding, Tomomi Chikaishi-Kirino, et al. IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of pulmonary hypertension. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 16. e2315123121
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Yoshiyuki Abe, Takao Fujii, Yoshia Miyawaki, Takahiko Sugihara, Haruhito A Uchida, Yasuhiro Maejima, Yoshiko Watanabe, Takuya Hashimoto, Takako Miyamae, Yoshikazu Nakaoka, et al. The real-world clinical decisions of physicians in the management of Takayasu arteritis and giant cell arteritis in Japan: A cross-sectional web-questionnaire survey. Modern Rheumatology. 2024
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MISC (119)：
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Yoshikazu Nakaoka, Katsuhisa Yamashita, Shinji Yamakido. Comment on: Long-term efficacy and safety of tocilizumab in refractory Takayasu arteritis: Final results of the randomized controlled phase 3 TAKT study: Reply. Rheumatology (United Kingdom). 2020. 59. 9. E48-E49
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真鍋 侑資, 森 啓悦, 熊ノ郷 淳, 中岡 良和. 大動脈置換術後に吻合部仮性瘤をくり返した高安動脈炎に対してIL-6阻害療法が有効であった1例. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2020. 64回. 599-599
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中岡 良和. 【肺高血圧症診療up to date最新の知見を診療に活かすために】治す 肺高血圧症基礎研究からの新規治療の展望. Heart View. 2020. 24. 3. 276-282
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中岡 良和. 【肺高血圧症診療最前線-これからの肺高血圧症診療に向けて】肺高血圧症の病態制御から治療へ 炎症性サイトカインに焦点を当てて. 医学のあゆみ. 2019. 271. 12-13. 1267-1272
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Hajime Yoshifuji, Haruhito Uchida, Yoshikazu Nakaoka, Takahiko Sugihara, Mitsuaki Isobe, Masayoshi Harigai. Long-term Clinical Course and Outcomes of 2013 Patients with Takayasu Arteritis. ARTHRITIS & RHEUMATOLOGY. 2019. 71
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Patents (1)：
Books (21)：
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Konnichinochiryoshishin
2024 ISBN:9784260053433
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Management of Cardiovascular Diseases based on the Current Guidelines
2023 ISBN:9784883789351
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血管・リンパ管の機能制御と疾患メカニズム
2022 ISBN:9784759817355
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Textbook of Rheumatology
2022 ISBN:9784524231584
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ASAKURA Internal Medicine
2022 ISBN:9784254322804
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Education (3)：
- 2000 - 2004 Osaka University Graduate School of Medicine
- 1992 - 1996 Osaka University School of Medicine
- 1987 - 1991 The University of Tokyo Fuculty of Science Department of Biophysics and Biochemistry
Professional career (1)：
Work history (9)：
- 2023/02 - 現在 National Cerebral and Cardiovascular Center Hospital Deputy Director General
- 2020/04 - 現在 Osaka University Graduate School of Medicine Department of Molecular Imaging in Cardiovascular Medicine
- 2016/01 - 現在 大阪大学大学院医学系研究科 循環器内科学 招へい教授
- 2016/01 - 現在 National Cerebral and Cardiovascular Center, Research Institute Department of Vascular Physiology Director
- 2013/10 - 2017/03 Japan Science and Technology Agency PRESTO
- 2015/08 - 2015/12 Osaka University Graduate School of Medicine Department of Cardiovascular Medicine Associate Professor
- 2009/11 - 2015/07 Osaka University Graduate School of Medicine Department of Cardiovascular Medicine Assistant Professor
- 2007/04 - 2009/10 Osaka University Graduate School of Medicine
- 2004/04 - 2007/03 National Cerebral and Cardiovascular Center, Research Institute Department of Structural Analysis
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Committee career (9)：
- 2024/04 - 現在 Japanese Pulmonary Circulation and Pulmonary Hypertension Society (JPCPHS) Director
- 2022/04 - 現在 International Society for Heart Research (ISHR) Fellow of International Society for Heart Research (FISHR)
- 2020/04 - 現在 日本血管生物医学会 理事、評議員
- 2019/04 - 現在 Japanese Circulation Society Fellow of Japanese Circulation Society (FJCS)
- 2017/04 - 現在 厚生労働省難治性血管炎に関する調査研究班 大型血管炎臨床分科会長
- 2017/01 - 現在 日本心臓病学会 Journal of Cardiology Cases Associated Editor
- 2014/04 - 現在 日本内科学会近畿支部 評議員
- 2011/12 - 現在 ISHR日本部会 評議員
- 2015/04 - 2018/03 日本循環器学会 血管炎症候群の診療ガイドライン改定・協力員
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Awards (4)：
- 2022/07 - Japanese Pulmonary Circulation and Pulmonary Hypertension Society Yamaki Prize
- 2014/07 - Osaka University Presidential Awards for Encouragement
- 2008/03 - Japanese Circulation Society Yagi Award for Cardiovascular Biochemical Research
- 2006 - 第10回心不全学会Young Investigator’s Award最優秀研究賞(2006年)
Association Membership(s) (8)：
日本心臓病学会
, The Japanese Vascular Biology and Meidicine Organization
, Japanese Section of ISHR
, 日本肺循環・肺高血圧学会
, American Heart Association
, 日本心不全学会
, 日本循環器学会
, 日本内科学会
