Rchr
J-GLOBAL ID:200901055856728274   Update date: Jan. 31, 2024

Okamoto Kuniaki

Okamoto Kuniaki
Research field  (1): Oral medicine
Research keywords  (3): oral cancer ,  intercellular transport ,  osteoclast
Research theme for competitive and other funds  (45):
  • 2023 - 2026 Roles of cancer extracellular vesicles in hijacking macrophages and metastatic niche formation
  • 2020 - 2023 三次元腫瘍オルガノイド評価系により見出された新規癌転移抑制化合物の創薬展開
  • 2017 - 2021 Drug repositioning using the gene promoter activity-based anticancer drug screening system
  • 2017 - 2021 MZF1-Driven Cancer Stem-Like Resistance Against Cell Stress
  • 2017 - 2020 Discovery of a novel gene regulating membrane trafficking of immune cells and elucidation of its pathology
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Papers (111):
  • Tatsuo Ogawa, Kisho Ono, Shoji Ryumon, Hotaka Kawai, Tomoya Nakamura, Koki Umemori, Kunihiro Yoshida, Hideka Kanemoto, Kyoichi Obata, Norie Yoshioka, et al. Novel mechanism of cisplatin resistance in head and neck squamous cell carcinoma involving extracellular vesicles and a copper transporter system. Head & neck. 2024
  • Kunihiro Yoshida, Kaung Htike, Takanori Eguchi, Hotaka Kawai, Htoo Shwe Eain, Manh Tien Tran, Chiharu Sogawa, Koki Umemori, Tatsuo Ogawa, Hideka Kanemoto, et al. Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion. Journal of oral biosciences. 2023
  • Fatima Farhana, Eiko Sakai, Yu Koyanagi, Yu Yamaguchi, Mohammad Ibtehaz Alam, Kuniaki Okamoto, Takayuki Tsukuba. Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase. Molecular biology reports. 2023
  • Mayuko Noguromi, Yu Yamaguchi, Keiko Sato, Shun Oyakawa, Kuniaki Okamoto, Hiroshi Murata, Takayuki Tsukuba, Tomoko Kadowaki. Rab44 Deficiency Induces Impaired Immune Responses to Nickel Allergy. International journal of molecular sciences. 2023. 24. 2
  • Manh Tien Tran, Yuka Okusha, Kaung Htike, Chiharu Sogawa, Takanori Eguchi, Tomoko Kadowaki, Eiko Sakai, Takayuki Tsukuba, Kuniaki Okamoto. HSP90 drives the Rab11a-mediated vesicular transport of the cell surface receptors in osteoclasts. Cell Biochemistry and Function. 2022. 40. 8. 838-855
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MISC (122):
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Books (13):
  • 第6版現代歯科薬理学
    医歯薬出版株式会社 2017
  • 第5版現代歯科薬理学
    医歯薬出版株式会社 2012
  • 「第4版現代歯科薬理学」
    医歯薬出版株式会社 2005
  • Arg-gingipain and Lys-gingipain: a novel class of cysteine proteinases.
    Birkhäusen Verlag 1999
  • Possible roles of N-linked oligosaccharides on cathepsin E
    IOS Press 1997
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Lectures and oral presentations  (47):
  • 新規腫瘍オルガノイド形成多元評価システムの薬剤スクリーニングへの応用
    (2019)
  • Keap1遺伝子欠損はNrf2の活性化を介して破骨細胞分化を抑制する
    (第40回日本分子生物学会年会/第90回日本生化学会大会 2017)
  • 口腔扁平上皮癌由来エクソソームニ含まれるプロテオームの特性
    (第40回日本分子生物学会年会/第90回日本生化学会大会 2017)
  • Transcription factor Sp1 regulates the expression of the murine cathepsin E gene in gastric adenosarcoma cells
    (第83回日本薬理学会年会 2010)
  • Transcription factor Sp1 regulates the expression of the murine cathepsin E gene in gastric adenosarcoma cells
    (2010)
more...
Works (3):
  • 破骨細胞におけるカテプシンEの役割と創薬にむけた基質分子の探究
    2009 - 2011
  • 骨疾患における創薬のターゲットとなりうるプロテアーゼの作用機序の解明
    2007 - 2009
  • 歯周病原性細菌の産生するプロテアーゼの膜輸送システムの解明
    2005 -
Professional career (1):
  • (BLANK) (Kyushu University)
Awards (1):
  • 2004 - 日本生化学会JB論文賞
Association Membership(s) (6):
日本分子生物学会 ,  病態と治療におけるプロテアーゼインヒビター研究会 ,  歯科基礎医学会 ,  日本薬理学会 ,  日本生化学会 ,  The molecular Biology Society of Japan
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