Hayashi Yoshio

ハヤシヨシオ | Hayashi Yoshio

Affiliation and department：

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (2)：創薬化学 , Medicinal Chemistry

Research theme for competitive and other funds (25)：

2020 - 2024 GTP代謝制御によるウイルス複製阻害技術の開発
2019 - 2023 Synthesis and Medicinal Chemical Development of Mid-Sized Peptide Conjugate Based on the Chemistry of Solid-Phase Disulfide Ligation
2016 - 2019 筋委縮性疾患克服を目指したマイオスタチン阻害ペプチドの創製研究
2015 - 2019 Studies on molecular functions of mid-size peptides derived from living system and their basic research for practical drug discovery
2016 - 2018 γ-チューブリンを標的とするジケトピラジン類の創製とケミカルバイオロジー研究

2014 - 2017 Development of brachytherapy for early stage oral cancer using I-125 seeds

2014 - 2016 天然由来ジペプチド様物質ネガマイシンを戦略分子とする創薬基盤研究

2011 - 2015 Integrated medicinal chemistry research of intractable diseases based on peptidic small molecules

2011 - 2014 Visualization of oral cancer microenvironment using molecular imaging and its application to radiotherapy

2011 - 2012 Study on Medicinal Chemistry of Reversible Cysteine Protease Inhibitors for the Treatment of Infectious Diseases

2011 - 2012 アリールケトン構造を有する非ペプチド型SARSウイルスプロテアーゼ阻害剤の開発

2008 - 2010 Study on Medicinal Chemistry, Chemical Biology and Chemical Pharmaceutics of Anticancer Drug Based on the Microtubule Targeting Agents

2008 - 2009 化学療法による遺伝病克服への挑戦:デュシェンヌ型筋ジストロフィーの治療薬の開発

2006 - 2007 腫瘍選択的血管内皮細胞障害物質フェニラヒスチンを戦略分子とする分子創薬基盤研究

2005 - 2007 Chemical Pharmaceutics Oriented Research on Medicinal Chemistry

2005 - 2005 腫瘍選択的血管内皮細胞障害物質フェニラヒスチンを戦略分子とする分子創薬基盤研究

2003 - 2005 Design and development of therapeutic drugs for intractable diseases based on molecular recognition of aspartic proteases

2003 - 2004 Development of Anticancer and Antiviral Agents Based on Diketopiperazine as a Bio-function-Mimicking Molecular Platform

2002 - 2002 アルツハイマー病克服をめざしたアミロイドセクレターゼ制御分子のデザインと合成

2000 - 2002 Molecular Function of Naturally Occurring Anti-microtubule Agent Phenylahistin (Determination of Structural Components Necessary for the Anti-microtubule activity t and Molecular Design for Drugs)

2000 - 2002 Design of resistance-surmountable HIV protease inhibitors based on molecular recognition analysis of mutant protease

ペプチドミメテックスの分子設計と合成研究

創薬化学に関する研究

Study on the design and synthesis of peptidomimetics

Study on Medicinal chemistry

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Papers (283)：

Yuki Yamauchi, Sho Konno, Noriko Omura, Narumi Yoshioka, Alexandra Hingst, Michael Gütschow, Christa E Müller, Akihiro Taguchi, Atsuhiko Taniguchi, Atsushi Kawaguchi, et al. Detection of Active SARS-CoV-2 3CL Protease in Infected Cells Using Activity-Based Probes with a 2,6-Dichlorobenzoyloxymethyl Ketone Reactive Warhead. ACS chemical biology. 2024. 19. 5. 1028-1034
Kyohei Muguruma, Akane Fukuda, Hayate Shida, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yuji Ito, Yoshio Hayashi. Structure Derivatization of IgG-Binding Peptides and Analysis of Their Secondary Structure by Circular Dichroism Spectroscopy. Chemical & pharmaceutical bulletin. 2024. 72. 9. 831-837
Noriko Omura, Akihiro Taguchi, Tomoki Kuwahara, Keisuke Hamada, Mizuki Watanabe, Masanori Nakakuki, Sho Konno, Kentaro Takayama, Atsuhiko Taniguchi, Toshifumi Nomura, et al. Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity. ACS Medicinal Chemistry Letters. 2023
Sho Konno, Miyu Tanaka, Tomoe Mizuguchi, Haruka Toyokai, Akihiro Taguchi, Atsuhiko Taniguchi, Yoshio Hayashi. Peptide mixed phosphonates for covalent complex formation with thioesterases in nonribosomal peptide synthetases. Journal of peptide science : an official publication of the European Peptide Society. 2023. e3532
Minagi Mukaiyama, Chihiro Uchiyama, Akane Fukuda, Yoshiki Nakazawa, Yuka Kuramochi, Yudai Shibata, Sho Konno, Kyohei Muguruma, Naohiro Matsugaki, Tomo Asari, et al. X-Ray Conformation and Structure-Activity Relationships of MA026, a Reversible Tight Junction Opener. Journal of medicinal chemistry. 2023. 66. 13. 8717-8724

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MISC (235)：

高山健太郎, 高山健太郎, 森健二, 齊藤梨沙, 佐々木優羽, 森戸克弥, 田口晃弘, 谷口敦彦, 宮里幹也, 長澤一樹, et al. Discovery of a novel partial agonist to human neuromedin U receptor 2. 日本薬学会年会要旨集(Web). 2022. 142年会. 28PO10-15
林良雄, 高山健太郎, 淺利知, 岡本英之, 根岸洋一, 常陸圭介, 土田邦博, 伊東史子, 谷口敦彦. 化学を基軸とする筋疾患研究マイオスタチン阻害ペプチドの創製. 日本筋学会学術集会プログラム・抄録集. 2021. 7回. 22-22
坂田萌, 田口晃弘, 倉石彩恵香, 今野翔, 高山健太郎, 高山健太郎, 谷口敦彦, 林良雄. One-pot synthesis of cyclic disulfide peptide with water-soluble Npys derivative. 日本薬学会年会要旨集(Web). 2021. 141st
岡本英之, 谷口敦彦, 宇佐美翔哉, 勝山雅大, 今野翔, 田口晃弘, 高山健太郎, 高山健太郎, 林良雄. 光酸素化能を付与した機能化ペプチドによるマイオスタチンの活性阻害. 創薬懇話会講演要旨集. 2021. 2021
坂田萌, 田口晃弘, 倉石彩恵香, 今野翔, 高山健太郎, 高山健太郎, 谷口敦彦, 林良雄. 水溶性Npys誘導体を用いたジスルフィドペプチドの効率的合成法開発. 創薬懇話会講演要旨集. 2021. 2021

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Lectures and oral presentations (1)：

Chemical synthesis of 71-meric neuregulin 1-β1
(Peptide Science 2008 2009)

Works (2)：

フェニラヒスチンの合成研究
2000 -
Joint Research on the total synthesis of phenylahistin
2000 -

Professional career (1)：

Doctor of Pharmaceutical Science (Kyoto University)

Work history (8)：

2007/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy
2001/04 - 2007/03 Kyoto Pharmaceutical University
1999/10 - 2001/03 Kyoto Pharmaceutical University
1999/04 - 1999/09 京都薬科大学非常勤講師
1988 - 1999 新日本製鐵株式会社技術開発本部先端技術研究所ライフサイエンス研究センター主任研究員

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Awards (1)：

2000 - 第9回日本薬学会医薬化学部会ポスター賞

Association Membership(s) (3)：

アメリカペプチド学会 , 日本ペプチド学会 , 日本薬学会

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