Rchr
J-GLOBAL ID:200901056584053163
Update date: Apr. 04, 2024
Hirota Seiichi
ヒロタ セイイチ | Hirota Seiichi
Affiliation and department:
Job title:
Professor
Research field (2):
Experimental pathology
, Human pathology
Research keywords (8):
Pathology
, Gastrointestinal tract
, カハール介在細胞
, 消化管の非上皮性腫瘍
, 異所石灰化
, Interstitial cells of Cajal
, Gastrointestinal Stromal Tumors
, ectopic calcification
Research theme for competitive and other funds (50):
- 2021 - 2024 深層学習による冠動脈粥腫自動診断システムの開発とその臨床応用に関する研究
- 2018 - 2023 The development of methods for inhibition of PD-L1 expression towards suppression of Epstein-Barr virus-related tumors
- 2016 - 2019 Development of diagnostic method and its application to treatment in GIST with particular mutations through creating monoclonal antibodies
- 2012 - 2015 Analysis of gene expression on interstitial cells of Cajal
- 2011 - 2014 Influence of various types of receptor tyrosine kinase gene mutations in pathogenesis of GISTs
- 2012 - 2012 腫瘍細胞株をもちいたGIST悪性化の関連分子の同定とその機能分析
- 2010 - 2012 Analysis of molecular mechanism and the regulation of adhesion
- 2009 - 2011 Diversity of imatinib-resistance clones in gastrointestinal stromal tumors
- 2007 - 2010 Analysis of the molecular mechanism in gastrointestinal pacemaker cell using KIT knock-in animal
- 2007 - 2009 A study of secondary resistance mechanism for molecular target drugs in gastrointestinal stromal tumors
- 2007 - 2009 Role of glycosylation in the oncogenesis of gastrointestinal sarcoma
- 2005 - 2009 Analysis of abnormal signaling through KIT and PDGFRA in development of gastrointestinal stromal tumors
- 2007 - 2008 アミノ酸の惹起する細胞内シグナル伝達の基礎研究と腸管蠕動不全治療の研究アプローチ
- 2004 - 2006 Molecular mechanisms of drug resistance in cancer.-GIST resistant to imatinib as a model-
- 2002 - 2004 Analysis of familial and multiple GIST
- 2002 - 2004 Pathological analysis of GIST using transgenic or knock-in-mouse
- 2002 - 2003 Control Mechanism of Intestinal Pacemaker Cell on Upper Gastrointestinal Motor Function
- 1999 - 2002 Mechanisms of the gastrointestinal motility dysfunction under septic conditions - a role of Interstitial Cells of Cajal -
- 2000 - 2001 Generation of gene-targetting mice with gain-of-function mutation of c-kit gene
- 2000 - 2000 消化管機能をコントロールする新たな細胞群
- 2000 - 2000 ヒト消化管ストローマ細胞腫瘍(GIST)患者の予後に対するc-kit変異の影響
- 1998 - 2000 Development of practically usefull Ws/Ws rat and its utilization
- 1998 - 2000 Roles of brain mast cells and their related substances in the central mechanisms of stress responses
- 1999 - 1999 ヒト消化管ストローマ細胞腫瘍(GIST)とc-kitの変異
- 1998 - 1999 Relation between gain-of-function mutation of c-kit gene and development of GIST
- 1998 - 1998 ヒト消化管ストローマ細胞腫瘍の発生・悪性化とc-kit機能獲得性突然変異の関係
- 1997 - 1998 Role of the c-kit tyrosine kinase in the genesis of gastrointestinal stromal tumors.
- 1997 - 1997 ヒト消化管筋層の間葉細胞腫の発生におけるc-kit突然変異の意義
- 1996 - 1997 マスト細胞におけるmi転写因子の機能とその異常の分子病理学的解析
- 1996 - 1996 cーkitミュータントラットにおけるカハール介在細胞欠損と胃内胆汁逆流の関係
- 1996 - 1996 mi転写因子による受容体チロシンキナーゼ癌原遺伝子の発現制御
- 1995 - 1996 Molecular analysis of abnormal fracture healing process
- 1996 - 消化管における間葉糸腫瘍発生の病理
- 1996 - 消化管におけるカハール介在細胞の生理病理
- 1996 - Pathology of Gastrointestinal Mesenchymal Tumors
- 1995 - 1995 細胞相互間の認識機構に広範囲な影響を与えるmiDNA結合蛋白標的遺伝子の単純
- 1994 - 1995 Analysis of Phenotypic Variation of Mast Cells by Using Messenger RNA Expression as a Marker
- 1994 - 1995 c-kit Mutant Rats as a Tool for Mast Cell Research-Development and Function
- 1994 - 1994 組織石灰化の分子病理学的研究
- 1993 - 1994 Research for Precursors of Mast Cells using Mast Cell-Deficient Ws/Ws Rats.
- 1993 - 1993 チロシンキナーゼ受容体癌原遺伝子の発現を制御するmi遺伝子の分離同定
- 1990 - 1993 Fibroblast-dependent Proliferation of Mast Cells
- 1992 - 1992 c-kitレセプターを介した細胞間相互作用ーマウスとラットの突然変異の比較ー
- 1991 - 1991 cーkitレセプタ-を介した細胞間相互作用ーマウスとラットの突然変異の比較ー
- 1988 - 1990 マスト細胞欠損マウスと培養マスト細胞を利用したマスト細胞機能解析システムの開発
- 1989 - 1989 配偶子成熟に必要な微小環境に欠陥をもたらすマウスのSl突然変異の発生工学的解析
- 1989 - 1989 細胞間相互作用が癌の増殖進展に与える影響:ミュータントマウス由来細胞による解析
- 異所石灰化組織における骨基質蛋白の発現
- Physiology and Pathology of interstitial cells of Cajal
- Expression of bone matrix protein mRNAs in ectopic calcification
Show all
Papers (477):
-
Reiko Fukui, Takahiro Watanabe, Koji Morimoto, Yukie Fujimoto, Masayuki Nagahashi, Eri Ishikawa, Seiichi Hirota, Yasuo Miyoshi. Reply to comment on 'An increase in tumor-infiltrating lymphocytes after treatment is significantly associated with a poor response to neoadjuvant endocrine therapy for estrogen receptor-positive/HER2-negative breast cancers' by Fukui et al. Breast cancer (Tokyo, Japan). 2024
-
Kazuteru Noguchi, Tetsuya Furukawa, Yoshiki Tatsumi, Shuhei Kasama, Takahiro Yoshikawa, Teppei Hashimoto, Naoto Azuma, Seiichi Hirota, Takashi Kimura, Kiyoshi Matsui. Involvement of YKL-40-positive macrophages commonly identified in polymyositis and dermatomyositis in the pathogenesis of myositis: a retrospective study. Immunological medicine. 2024. 47. 1. 37-44
-
Ken Wakimoto, Yu Wakimoto, Ikuo Matsuda, Satoshi Yoshihara, Yuji Ukita, Atushi Fukui, Seiichi Hirota, Hiroaki Shibahara. A case of non-Hodgkin lymphoma of the upper gingiva with minimal residual disease detected in cryopreserved ovarian tissue: A case report. The journal of obstetrics and gynaecology research. 2024. 50. 3. 526-529
-
Ryugo Teranishi, Tsuyoshi Takahashi, Shinsuke Sato, Katsunobu Sakurai, Kentaro Kishi, Hisahiro Hosogi, Takuya Nakai, Yukinori Kurokawa, Junya Fujita, Toshirou Nishida, et al. The impact of contour maps on estimating the risk of gastrointestinal stromal tumor recurrence: indications for adjuvant therapy: an analysis of the Kinki GIST registry. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2024. 27. 2. 355-365
-
Toshirou Nishida, Yoichi Naito, Tsuyoshi Takahashi, Takuro Saito, Shigeo Hisamori, Dai Manaka, Katsuhiro Ogawa, Seiichi Hirota, Hitoshi Ichikawa. Molecular and clinicopathological features of KIT/PDGFRA wild-type gastrointestinal stromal tumors. Cancer science. 2024. 115. 3. 894-904
more...
MISC (84):
-
Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Akaki Kotaro, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Tomonori Hirano, et al. Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability. CANCER RESEARCH. 2020. 80. 16
-
Masashi Fujita, Nagahide Matsubara, Ikuo Matsuda, Tomoki Yamano, Akihiro Fujimoto, Satoru Miyano, Naohiro Tomita, Seiichi Hirota, Hiroki Ikeuchi, Hidewaki Nakagawa. Precision oncology by genomic profiling for colitic cancer indicates potentials for cancer diagnosis and treatment. CANCER SCIENCE. 2018. 109. 834-834
-
Rika Kawakami, Takahiro Imanaka, Masaharu Ishihara, Takako Kihara, Kenichi Fujii, Seiichi Hirota, Hiroyuki Hao. Protruding in-stent mass after bioresorbable polymer sirolimus-eluting stent - Ex vivo intravascular imaging and histopathology -. Circulation Journal. 2018. 82. 3. 932-933
-
Masashi Fujita, Nagahide Matsubara, Kazuhiro Maejima, Tomoki Yamano, Ikuo Matsuda, Seiichi Hirota, Hiroki Ikeuchi, Naohiro Tomita, Hidewaki Nakagawa. Genetic profiling of colitis-associated cancer indicates de novo carcinogenesis and the impact of chronic inflammation. CANCER RESEARCH. 2017. 77
-
Tsuyoshi Takahashi, Seiichi Hirota, Yashuhiro Miyazaki, Yukinori Kurokawa, Tomonori Makino, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Masaki Mori, Yuichiro Doki. The mutation status of KIT and PDGFRA of GIST patients in Japan. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2016. 31. 57-57
more...
Education (4):
- - 1988 Osaka University
- - 1988 Osaka University Graduate School, Division of Medicine
- - 1984 Hyogo College of Medicine Faculty of Medicine
- - 1984 Hyogo College of Medicine Faculty of Medicine
Professional career (1):
- (BLANK) (Osaka University)
Work history (5):
- 2004/09 - 現在 Hyogo Medical University Faculty of Medicine Department of Medicine Professor
- 1998 - - 大阪大学医学部 助教授
- 1998 - - Associate Professor, Osaka University Medical School
- 1989 - - 大阪大学医学部 助手
- 1989 - - Assistant Professor, Osaka University Medical School
Committee career (1):
Awards (1):
Association Membership(s) (4):
日本臨床細胞学会
, 日本血液学会
, 日本癌学会
, 日本病理学会
Return to Previous Page