Toyoda Taro

トヨダタロウ | Toyoda Taro

Affiliation and department：
Job title： Junior Associate Professor
Homepage URL (1)： https://sites.google.com/view/toyodatgroup/%E3%83%9B%E3%83%BC%E3%83%A0

Research field (1)： Metabolism and endocrinology

Research keywords (8)： cell therapy , islet transplantation , regenerative medicine , iPS cell , pancreas , 5'AMP-activated protein kinase , glucose transport , skeletal muscle

Research theme for competitive and other funds (8)：

2019 - 2022 iPS細胞由来膵島細胞(iPIC)を用いた1型糖尿病に対する細胞治療の製造法開発及び非臨床試験の実施
2018 - 2021 Molecular mechanisms regulating the differentiation for pancreatic bud-like cells from human pluripotent stem cells
2015 - 2018 Mechanism based development of differentiation method for pancreatic bud-like cells from human pluripotent stem cells
2013 - 2015 Development and verification of implantable pancreatic epithelial cells from human pluripotent stem cell
2011 - 2013 Action mechanism of functional food and natural medicine focusing on AMP kinase and related signaling molecules in skeletal muscle

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Papers (52)：

Ryo Ito, Azuma Kimura, Yurie Hirose, Yu Hatano, Atsushi Mima, Shin-Ichi Mae, Yamato Keidai, Toshihiro Nakamura, Junji Fujikura, Yohei Nishi, et al. Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model. Scientific reports. 2023. 13. 1. 8659-8659
Yuta Tsujisaka, Takeshi Hatani, Chikako Okubo, Ryo Ito, Azuma Kimura, Megumi Narita, Kazuhisa Chonabayashi, Shunsuke Funakoshi, Antonio Lucena-Cacace, Taro Toyoda, et al. Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting. Stem cell reports. 2022. 17. 7. 1772-1785
Ryo Suenaga, Shuhei Konagaya, Junji Yamaura, Ryo Ito, Satoshi Tanaka, Yoichi Ishizaki, Taro Toyoda. Microwell bag culture for large-scale production of homogeneous islet-like clusters. Scientific reports. 2022. 12. 1. 5221-5221
Hideyuki Hiyoshi, Kensuke Sakuma, Noriko Tsubooka-Yamazoe, Shinya Asano, Taisuke Mochida, Junji Yamaura, Shuhei Konagaya, Ryo Fujii, Hirokazu Matsumoto, Ryo Ito, et al. Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC. Scientific reports. 2022. 12. 1. 4740-4740
Azuma Kimura, Taro Toyoda, Mio Iwasaki, Ryusuke Hirama, Kenji Osafune. Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells. Cell chemical biology. 2020. 27. 12. 1561-1572

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MISC (80)：

小長谷周平, 末永亮, 山浦順司, 山浦順司, 伊藤亮, 田中郷史, 石崎庸一, 豊田太郎, 豊田太郎. 多孔培養バッグを用いた均一細胞凝集塊の大量作製. 日本再生医療学会総会(Web). 2022. 21st
小長谷周平, 小長谷周平, 末永亮, 山浦順司, 山浦順司, 伊藤亮, 伊藤亮, 田中郷史, 石崎庸一, 豊田太郎, et al. 多孔培養バッグを用いた均一な膵島様凝集塊の作製. 日本膵・膵島移植研究会プログラム・抄録集. 2021. 48th
木村東, 豊田太郎, 岩崎未央, 平間竜介, 長船健二. 再生医療応用に向けたヒトES/iPS細胞由来膵前駆細胞の増殖機序の解明. 日本再生医療学会総会(Web). 2021. 20th
穴澤貴行, 多田誠一郎, 山根佳, 井ノ口健太, 江本憲央, 藤本七恵, 藤倉純二, 稲垣暢也, 豊田太郎, 坂口志文. 膵島移植と再生医療. 日本再生医療学会総会(Web). 2021. 20th
木村東, 豊田太郎, 岩崎未央, 平間竜介, 長船健二. 糖尿病に対する細胞療法確立に向けたヒトES/iPS細胞由来膵前駆細胞の増殖機序の解明. 糖尿病(Web). 2021. 64. Suppl

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Patents (37)：

増殖抑制剤
インスリン産生細胞
細胞製造法
細胞製造法
増殖抑制剤

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Books (11)：

糖尿病最新の治療2022-2024
南江堂 2021 ISBN:9784524229963
糖尿病最新の治療2019-2021
南江堂 2019 ISBN:9784524245567
再生医療
南江堂 2015
糖尿病学
西村書店 2015
膵島の再生医療
診断と治療社 2015

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Lectures and oral presentations (113)：

Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model
(International Diabetes Federation Western Pacific Region Congress 2023 15th Scientific Meeting of the Asian Association for the Study of Diabetes 2023)
Strategies for reducing non-endocrine cells in stem cell-derived islets
(4th IPITA/HSCI/JDRF summit 2023 2023)
膵内分泌細胞誘導因子ALK5 inhibitor IIの置き換えによる造腫瘍性懸念の回避
(第22回日本再生医療学会総会 2023)
ヒトiPS細胞分化モデルを用いた膵内胚葉分化におけるHHEXの役割の解明
(第22回日本再生医療学会総会 2023)
iPS細胞胚様体の局所刺激による分化誘導を目指したマイクロデバイスの開発
(第45回日本分子生物学会年会 2022)

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Education (5)：

2003 - 2006 Kyoto University Graduate School of Agriculture
2001 - 2003 Kyoto University Graduate School of Agriculture
- 2003 Kyoto University Graduate School, Division of Agriculture
1997 - 2001 Kyoto University Faculty of Agriculture
- 2001 Kyoto University Faculty of Agriculture

Professional career (1)：

Doctor of Agriculture (Kyoto University)

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