Rchr
J-GLOBAL ID：200901057610502741   Update date: Sep. 19, 2024

Shirao Tomoaki

Shirao Tomoaki | Shirao Tomoaki
Affiliation and department：
AlzMed, Inc.

About AlzMed, Inc.


Job title： President
Homepage URL  (2)： https://www.alzmed.jp/ ,  http://neuro.med.gunma-u.ac.jp/
Research field  (4)： Applied molecular and cellular biology ,  Applied molecular and cellular biology ,  Neuroscience - general ,  Cell biology
Research keywords  (15)： diagnostics ,  therapeutics ,  Alzheimer's disease ,  樹状突起スパイン ,  可塑性 ,  高次脳機能 ,  細胞培養 ,  海馬 ,  ドレブリン ,  形態形成 ,  アクチン ,  シナプス ,  神経科学 ,  細胞生物学 ,  cell biology neuroscience synapse actin morphogenesis drebrin hippocampus cell culture higher brain function plasticity dendritic spine
Research theme for competitive and other funds  (38)：
  • 2017 - 2020 Actin-based model of synaptic plasticity
  • 2015 - 2017 Study for the mechanisms of intercellular signaling of glial cells in the central nervous system
  • 2010 - 2016 Comprehensive Brain Science Network
  • 2010 - 2012 Role of Drebrin in the regulation of ocular dominance plastiity
  • 2010 - 2011 Mapping of the developmental stages of neurons in the brain using the radiosensitivity as an index.
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Papers (258)：
  • Yuki Kajita, Nobuhiko Kojima, Tomoaki Shirao. A lack of drebrin causes olfactory impairment. Brain and Behavior. 2023. 14. 1
  • Hiroyuki Yamazaki, Tomoaki Shirao. The Nuclear Export and Dendritic Spine Localization of Transcriptional-regulator Spikar/ZMYND8. The Kitakanto Medical Journal. 2023. 73. 4. 293-298
  • Hiroyuki Yamazaki, Noriko Koganezawa, Hideaki Yokoo, Yuko Sekino, Tomoaki Shirao. Super-resolution imaging reveals the relationship between CaMKIIβ and drebrin within dendritic spines. Neuroscience Research. 2023
  • Mai Yamamura, Kenji Hanamura, Noriko Koganezawa, Senami Furubayashi, Tomoaki Shirao, Hiroshi Kawabe. Impacts of methotrexate on survival, dendrite development, and synapse formation of cortical neurons. Genes to cells : devoted to molecular & cellular mechanisms. 2023. 28. 8. 563-572
  • Noriko Koganezawa, Reiko T Roppongi, Yuko Sekino, Izuo Tsutsui, Ayaka Higa, Tomoaki Shirao. Easy and Reproducible Low-Density Primary Culture using Frozen Stock of Embryonic Hippocampal Neurons. Journal of visualized experiments : JoVE. 2023. 191
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MISC (613)：
  • Kazutaka Ikeda, Soichiro Ide, Hiromi Takahashi-Omoe, Masabumi Minami, Hisatsugu Miyata, Mitsuo Kawato, Hitoshi Okamoto, Tetsuro Kikuchi, Yumiko Saito, Tomoaki Shirao, et al. Required research activities to overcome addiction problems in Japan. Taiwanese Journal of Psychiatry. 2021. 35. 1. 6-11
  • YAMAZAKI Hiroyuki, HANAMURA Kenji, SEGAWA Banri, TSUKAHARA Narutoshi, MURAKAMI Akikazu, SHIRAO Tomoaki. Live cell imaging of endogenous drebrin using camelidae single-domain antibody. Journal of Physiological Sciences (Web). 2020. 70. Supplement 1
  • 三木大輔, 小林勇喜, 河渕省吾, 宮本達雄, 小金澤紀子, 武井延之, 関野祐子, 白尾智明, 斎藤祐見子. 神経細胞一次繊毛局在型GPCRを介するシグナルは繊毛の長さを調節する. 日本生化学会大会(Web). 2019. 92nd
  • YAMAZAKI Hiroyuki, HANAMURA Kenji, TSUKAHARA Narutoshi, SEGAWA Banri, MURAKAMI Akikazu, SHIRAO Tomoaki. ドレブリンナノボディの開発. 日本神経化学会大会抄録集(Web). 2019. 62nd
  • Kenji Hanamura, Yousuke Kamata, Hiroyuki Yamazaki, Nobuhiko Kojima, Tomoaki Shirao. Isoform-dependent Regulation of Drebrin Dynamics in Dendritic Spines. Neuroscience. 2018. 379. 67-76
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Patents (2)：
  • ドレブリンA発現抑制作用を有するアンチセンスオリゴヌクレオチド
  • ドレブリンA発現抑制動物神経細胞及び非ヒトモデル動物
Books (9)：
  • オックスフォード生理学 原書4班
    丸善出版 2016
  • リッピンコットシリーズ イラストレイテッド 神経科学
    丸善出版 2013
  • インテグレーテッドシリーズ6 神経科学
    東京科学同人 2011
  • Role for signal propagation through the hippocampal CA2 field in memory formation
    Lecture Notes in Artificial Intelligence. 2007
  • Role for signal propagation through the hippocampal CA2 field in memory formation
    Lecture Notes in Artificial Intelligence. 2007
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Lectures and oral presentations  (540)：
  • A role of drebrin A in the activity-dependent trafficking of NMDA receptors to the plasma membrane
    (第58回日本神経化学大会 2015)
  • Allopregnanolone induces increase of excitatory synapses via protein kinase A activation
    (第58回日本神経化学大会 2015)
  • Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid beta oligomers
    (第58回日本神経化学大会 2015)
  • Early stage development of human iPSCs-derived neurons and its application to non-clinical study
    (第58回日本神経化学大会 2015)
  • Deletion of drebrin A impairs hippocampal synaptic plasticity and hippocampus-dependent fear learning in adulthood
    (第58回日本神経化学大会 2015)
ｍore...
Education (4)：
  • - 1984 Gunma University
  • - 1984 Gunma University Graduate School of Medicine Pharmacology
  • - 1980 Gunma University Faculty of Medicine
  • - 1980 Gunma University Faculty of Medicine
Professional career (1)：
  • (BLANK) (Gunma University)
Work history (13)：
  • 2020/04 - 現在 AlzMed, Inc. central office President
  • 2019/04 - 2020/03 Gunma University
  • 2019/04 - 2020/03 Gunma University Vice President
  • 1993 - 2003 群馬大学医学部付属行動医学研究施設 行動分析学分野 教授
  • 1993 - 2003 Gunma University School of Medicine, Department of Neurobiology and Behavior, Professor
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Committee career (21)：
  • 2007 - 2011 日本生理学会 常任幹事(2007~2011)、学術研究委員会委員長(2008~2011)
  • 2011 - International program chair of ISN 2011 meeting at Athens
  • 2011 - 学術研究委員会委員(2011~)
  • 2011 - International program chair of ISN 2011 meeting at Athens
  • International Society of Radiation Neurobiology President
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Awards (1)：
  • 1996 - 日本医師会医学研究助成
Association Membership(s) (10)：
International Society of Radiation Neurobiology ,  新学術領域研究[包括的脳科学研究推進ネットワーク」 ,  International Society for Neurochemsitry ,  日本神経科学学会 ,  神経組織の成長再生移植研究会 ,  日本生理学会 ,  日本神経化学会 ,  日本薬理学会 ,  International Society of Radiation Neurobiology ,  International Society for Neurochemsitry
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