Rchr
J-GLOBAL ID：200901057616466003
Update date: Nov. 11, 2024
Tanaka Sakae
タナカ サカエ | Tanaka Sakae
Affiliation and department：
Job title：
Associate Professor
Homepage URL (1)：
http://www.h.u-tokyo.ac.jp/ortho/
Research field (1)：
Orthopedics
Research keywords (2)：
整形外科学
, Orthopedic surgery
Research theme for competitive and other funds (70)：
- 2022 - 2025 画像検査と人工知能の融合による膝関節キネマティクスの予測システムの開発
- 2021 - 2024 転写因子Hhexによる破骨細胞・マクロファージ制御機構と骨関節疾患への関与
- 2020 - 2024 AI-assisted diagnostic system for osteoporosis
- 2019 - 2024 Establishment of an integrated locomotive science including dynamics of bone-articular cells and regulation by immune system
- 2019 - 2022 Elucidation of articular joint homeostasis regulated by the cellular network in the synovium
- 2019 - 2022 Characteristics of three-dimensional acetabular morphology of patients with rotational acetabular osteotomy
- 2018 - 2022 Prg4に立脚した、細胞・分子の多層的アプローチによる関節形成・維持機構の解明
- 2018 - 2021 Novel fracture treatment by prevention of bacterial adherence and biofilm formation
- 2017 - 2020 Comprehensive research for molecular regulation of development, homeostasis, and degeneration of spine
- 2017 - 2020 Utilization and usefulness of big data on postoperative knee joint dynamics using IT global network
- 2016 - 2019 Support tools for evaluating osteoporosis therapeutic effects with rheumatoid arthritis patients
- 2015 - 2018 On the regulatory mechanism of hard tissue metabolism by 8-nitro-cGMP
- 2014 - 2018 Epigenetics in osteoclastogenesis
- 2013 - 2016 Radiograhic quantifications of joint space narrowing by computer-based approach on rheumatoid arthritis patients
- 2011 - 2013 Elucidation of the mechanism of action of anti-RANKL antibody for treatment of metabolic bone disease.
- 2011 - 2013 Regulation of osteoclast function by AMPK activity
- 2011 - 2012 Molecular mechanism of bone-resorption in osteoclasts through microtubule regulation
- 2010 - 2012 Distinguishing the Proapoptotic and Antiresorptive Functions of Bisphosphonates inMurine Osteoclasts
- 2010 - 2012 Functional and morphological analysis of mitochondria in osteoclastic bone resorption
- 2011 - 2011 TGF-βによる破骨細胞分化に関わる遺伝子群の解明
- 2010 - 2011 破骨細胞分化のエピジェネティックな制御機構の解明
- 2010 - 2011 Regulatory mechanisms of osteoclast apoptosis by Bim and Puma
- 2009 - 2011 Crosstalk of TGF signal and TRAF signal in osteoclastogenesis
- 2009 - 2011 Molecul ar epidemiological study of the regulation of bone and joint destruction through intracellular ATP and ROS levels
- 2008 - 2011 Basic research on the integrated regulation of locomotive function
- 2007 - 2011 The integrated study for molecular backgrounds and therapeutic targets of osteoarthritis : The ROAD project.
- 2009 - 2010 アポトーシス制御分子による破骨細胞エネルギー産生調節メカニズムに関する研究
- 2007 - 2009 EFFECT OF CASPASE 3 ON BONE METABOLISM
- 2007 - 2008 滑膜肉腫キメラ遺伝子SYT/SSX関連タンパクの網羅的解析による分子標的薬の開発
- 2007 - 2008 Molecular epidemiological study of the regulation of osteoclastic bone resorption
- 2007 - 2008 末梢神経の髄鞘成熟における転写因子Soxファミリーの機能解析
- 2006 - 2008 Regulation of chondrogenic differentiation of synovial fibroblasts by BMP signaling and the effect of proinflammtory cytokines
- 2005 - 2008 破骨細胞分化誘導因子可溶化の分子メカニズムの解明
- 2006 - 2007 Functional analysis of apoptosis-related proteins in osteoclasts
- 2005 - 2007 REGULATION OF ECTODOMAIN SHEDDING OF RANKL
- 2005 - 2006 The analysis of the mechanism of chondrocyte differentiation and apoptosis
- 2005 - 2006 ミエリン関連糖蛋白(MAG)プロモーター解析による髄鞘形成プログラムの解明
- 2004 - 2006 Discovery for the Target Molecules to Control. Glial Scar Formation after Spinal Cord Injury
- 2004 - 2005 Study of the role of small G proteins on the activation and apoptosis of the osteoclast.
- 2003 - 2005 Analysis of functional disturbance of chondroctyes in oseoarthritis and establishment of new therapeutic strategies for the disease.
- 2003 - 2004 Study of the molecular mechanism of osteoclast apoptosis.
- 2003 - 2004 Research for articular cartilage regeneration using overexpression of intracellular signal transduction molecules.
- 2003 - 2004 外来遺伝子導入によるシュワン細胞分化制御とこれを用いた人工神経の開発についての研
- 2003 - 2004 運動器疾患におけるユビキチンシステムの関与とその制御に関する研究
- 2002 - 2004 Study of the therapeutic vaccine approach targeting RANKL.
- 2001 - 2004 Study of the molecular targeting therapy for rheumatoid arthritis.
- 2002 - 2003 The Studies Regarding Gene Transfer for the Promotion of Bone Ligament Healing
- 2002 - 2003 慢性関節リウマチにおける腱断裂機序の解明と治療法の確立
- 2001 - 2003 Study of the role of TRAF6 on differentiation and activation of the osteoclast.
- 2000 - 2003 Study of regeneration of peripheral nervous system with adenoviral vectors
- 2000 - 2002 Involvement of the aging-suppressor gene klotho in the skeletal
- 2000 - 2001 DEVELOPMENT OF A NEW THERAPEUTC APPROCH TO BONE REGENERATION FOR GENE THERAPY
- 2000 - 2001 Intracellulan signal : ry pathways involving bone destruction
- 1998 - 2001 Gene therapy of spinal cord injury by adenovirus vector-mediated gene transduction
- 1999 - 2000 The Studies towards Inhibition of Joint Adhesion by Decorin Gene Transtection Techrique
- 1999 - 2000 The Studies towards Prevention of Osteoarthritis of the knee joint Using Adenovirus Vector Encording Hyaluronic Acid Synthe tase Type-2 Gene
- 1999 - 2000 破骨細胞活性化を制御する細胞内シグナルの研究
- 1998 - 2000 The Studies Regarding Gene Transfer for the Ligament Healing with Adenovirus Vector
- 1997 - 2000 Study on adenovirua vector-mediated gene therapy as a therapeuticc approach for bone diseases
- 脊髄損傷の治療
- 骨関節破壊の遺伝子治療
- 骨軟骨の再生
- 脊髄損傷の遺伝子治療
- 骨吸収の分子メカニズムの研究
- Treatment of spinal cord injury
- regeneration of bone and cartilage
- Gene therapy of bone and joint destruction
- Regeneration of bone and cartilage
- Gene therapy of spinal cord injury
- Study on mechanism of bone destruction in arthritis
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Papers (511)：
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Ryutaro Takeda, Akihiro Uchio, Toshiko Iidaka, Kenta Makabe, Taro Kasai, Yasunori Omata, Noriko Yoshimura, Sakae Tanaka, Takumi Matsumoto. Automatic Hardy and Clapham's classification of hallux sesamoid position on foot radiographs using deep neural network. Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons. 2024
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Tatsuyuki Fukui, Asuka Terashima, Yasunori Omata, Ryota Chijimatsu, Kazuo Okamoto, Masayuki Tsukasaki, Yukiko Fukuda, Tadayoshi Hayata, Akiyoshi Saitoh, Etsuko Toda, et al. Disulfiram ameliorates bone loss in ovariectomized mice by suppressing osteoclastogenesis. Journal of bone and mineral metabolism. 2024
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Takahiro Arakawa, Kenichi Kono, Tetsuya Tomita, Takaharu Yamazaki, Masashi Tamaki, Shoji Konda, Teruya Ishibashi, Ryota Yamagami, Kohei Kawaguchi, Tomofumi Kage, et al. Method for defining the horizontal plane in fluoroscopic kinematic analysis. Journal of Joint Surgery and Research. 2024. 2. 3. 99-105
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Asuka Terashima, Kumiko Ono, Yasunori Omata, Sakae Tanaka, Taku Saito. Inflammatory diseases causing joint and bone destruction: rheumatoid arthritis and hemophilic arthropathy. Journal of bone and mineral metabolism. 2024. 42. 4. 455-462
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Kenta Makabe, Hiroyuki Okada, Naohiro Tachibana, Hisatoshi Ishikura, Norihito Ito, Masaru Tanaka, Ryota Chijimatsu, Asuka Terashima, Fumiko Yano, Meiko Asaka, et al. Baricitinib ameliorates inflammatory and neuropathic pain in collagen antibody-induced arthritis mice by modulating the IL-6/JAK/STAT3 pathway and CSF-1 expression in dorsal root ganglion neurons. Arthritis research & therapy. 2024. 26. 1. 121-121
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MISC (427)：
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谷口優樹, 松林嘉孝, 加藤壯, 大島寧, 田中栄. Spinal deformity in Marfan syndrome. 関節外科. 2023. 42. 4
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谷口優樹, 谷口優樹, 松林嘉孝, 加藤壯, 大島寧, 田中栄, 池田敏之, 岡崎仁, 深柄和彦. 脊椎手術における完全自己血由来フィブリン糊の使用成績. 医療機器学. 2023. 93. 2
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松村雅仁, 大和志匡, 游敬, 加藤壯, 谷口優樹, 松林嘉孝, 大島寧, 田中栄. 脊柱側弯症術後にRod折損を2度生じたGorham-Stout syndromeの1例. 関東整形災害外科学会雑誌. 2023. 54. 2
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松林嘉孝, 谷口優樹, 加藤壯, 大友望, 田中栄, 大島寧. Clinical results of unilateral total facetectomy without instrumentation for spinal tumors. Journal of Spine Research (Web). 2023. 14. 3
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大友望, 加藤壯, 佐々木克幸, 大和志匡, 游敬, 游敬, 永田向生, 土肥透, 谷口優樹, 松林嘉孝, et al. Comparison between laminectomy and fenestration for lumbar spinal canal stenosis with spinal epidural lipomatosis-Multicenter research-. Journal of Spine Research (Web). 2023. 14. 3
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Books (6)：
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Skeletal Biology and Medicine: Aspects of Bone Morphogensis and Remodeling
New York Academy of Sciences 2008 ISBN:1573316849
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人工膝関節置換術〈TKA〉のすべて 安全・確実な手術のために
メジカルビュー社 2007 ISBN:9784758310208
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新骨の科学
医歯薬出版 2007 ISBN:4263456092
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Osteoimmunology (Advances in Experimental Medicine and Biology)
Springer-Verlag 2007 ISBN:0387720081
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Skeletal Development and Remodeling in Health, Disease, and Aging
New York Academy of Sciences 2006 ISBN:1573315834
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Education (4)：
- - 1996 The University of Tokyo
- - 1996 The University of Tokyo Graduate School, Division of Medicine
- - 1987 The University of Tokyo Faculty of Medicine School of Medicine
- - 1987 The University of Tokyo Faculty of Medicine
Professional career (1)：
- Ph.D. (The University of Tokyo)
Work history (2)：
- 2023/04 - 現在 The University of Tokyo Hospital Director
- 2012/01 - 現在 東京大学大学院医学系研究科外科学専攻 整形外科学 教授
Committee career (6)：
- 2007 - - 日本リウマチ学会 Modern Rheumatology編集委員会
- 2007 - - 日本整形外科学会学会誌編集委員会
- 2005 - - 日本整形外科学会専門医試験委員会
- 2005 - - 日本整形外科学会学術用語委員会
- 日本リウマチ学会 評議員 リウマチ専門医 リウマチ指導医
- 日本骨代謝学会 評議員
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Awards (12)：
- 2018 - F1000Prime Awards: Faculty Member of The Year (RHEUMATOLOGY & CLINICAL IMMUNOLOGY)
- 2017 - F1000Prime Awards: Faculty Member of The Year (RHEUMATOLOGY & CLINICAL IMMUNOLOGY)
- 2011 - 日本骨粗鬆症学会 研究奨励賞
- 2010 - BONE Top Reviewer 2009-2010
- 2003 - 東日本整形災害外科学会学術集会奨励賞
- 2003 - 日本リウマチ学会賞
- 2002 - 日本骨代謝学会学術賞
- 1998 - 日本整形外科学会奨励賞
- 1997 - Julius-Wolff Award
- 1997 - アルケア奨励賞
- 1993 - アメリカ骨代謝学会奨励賞
- 1992 - 日本骨代謝学会奨励賞
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Association Membership(s) (5)：
日本分子生物学会
, 日本リウマチ学会
, 日本骨代謝学会
, アメリカ骨代謝学会(American society for bone and mineral research)
, 日本整形外科学会
