Rchr

J-GLOBAL ID：200901057616466003 Update date: Jun. 06, 2024

Tanaka Sakae

タナカサカエ | Tanaka Sakae

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.h.u-tokyo.ac.jp/ortho/

Research field (1)： Orthopedics

Research keywords (2)：整形外科学 , Orthopedic surgery

Research theme for competitive and other funds (70)：

2022 - 2025 画像検査と人工知能の融合による膝関節キネマティクスの予測システムの開発
2021 - 2024 転写因子Hhexによる破骨細胞・マクロファージ制御機構と骨関節疾患への関与
2020 - 2024 AI-assisted diagnostic system for osteoporosis
2019 - 2024 Establishment of an integrated locomotive science including dynamics of bone-articular cells and regulation by immune system
2019 - 2022 Elucidation of articular joint homeostasis regulated by the cellular network in the synovium

2019 - 2022 Characteristics of three-dimensional acetabular morphology of patients with rotational acetabular osteotomy

2018 - 2022 Prg4に立脚した、細胞・分子の多層的アプローチによる関節形成・維持機構の解明

2018 - 2021 Novel fracture treatment by prevention of bacterial adherence and biofilm formation

2017 - 2020 Comprehensive research for molecular regulation of development, homeostasis, and degeneration of spine

2017 - 2020 Utilization and usefulness of big data on postoperative knee joint dynamics using IT global network

2016 - 2019 Support tools for evaluating osteoporosis therapeutic effects with rheumatoid arthritis patients

2015 - 2018 On the regulatory mechanism of hard tissue metabolism by 8-nitro-cGMP

2014 - 2018 Epigenetics in osteoclastogenesis

2013 - 2016 Radiograhic quantifications of joint space narrowing by computer-based approach on rheumatoid arthritis patients

2011 - 2013 Elucidation of the mechanism of action of anti-RANKL antibody for treatment of metabolic bone disease.

2011 - 2013 Regulation of osteoclast function by AMPK activity

2011 - 2012 Molecular mechanism of bone-resorption in osteoclasts through microtubule regulation

2010 - 2012 Distinguishing the Proapoptotic and Antiresorptive Functions of Bisphosphonates inMurine Osteoclasts

2010 - 2012 Functional and morphological analysis of mitochondria in osteoclastic bone resorption

2011 - 2011 TGF-βによる破骨細胞分化に関わる遺伝子群の解明

2010 - 2011 破骨細胞分化のエピジェネティックな制御機構の解明

2010 - 2011 Regulatory mechanisms of osteoclast apoptosis by Bim and Puma

2009 - 2011 Crosstalk of TGF signal and TRAF signal in osteoclastogenesis

2009 - 2011 Molecul ar epidemiological study of the regulation of bone and joint destruction through intracellular ATP and ROS levels

2008 - 2011 Basic research on the integrated regulation of locomotive function

2007 - 2011 The integrated study for molecular backgrounds and therapeutic targets of osteoarthritis : The ROAD project.

2009 - 2010 アポトーシス制御分子による破骨細胞エネルギー産生調節メカニズムに関する研究

2007 - 2009 EFFECT OF CASPASE 3 ON BONE METABOLISM

2007 - 2008 滑膜肉腫キメラ遺伝子SYT/SSX関連タンパクの網羅的解析による分子標的薬の開発

2007 - 2008 Molecular epidemiological study of the regulation of osteoclastic bone resorption

2007 - 2008 末梢神経の髄鞘成熟における転写因子Soxファミリーの機能解析

2006 - 2008 Regulation of chondrogenic differentiation of synovial fibroblasts by BMP signaling and the effect of proinflammtory cytokines

2005 - 2008 破骨細胞分化誘導因子可溶化の分子メカニズムの解明

2006 - 2007 Functional analysis of apoptosis-related proteins in osteoclasts

2005 - 2007 REGULATION OF ECTODOMAIN SHEDDING OF RANKL

2005 - 2006 The analysis of the mechanism of chondrocyte differentiation and apoptosis

2005 - 2006 ミエリン関連糖蛋白(MAG)プロモーター解析による髄鞘形成プログラムの解明

2004 - 2006 Discovery for the Target Molecules to Control. Glial Scar Formation after Spinal Cord Injury

2004 - 2005 Study of the role of small G proteins on the activation and apoptosis of the osteoclast.

2003 - 2005 Analysis of functional disturbance of chondroctyes in oseoarthritis and establishment of new therapeutic strategies for the disease.

2003 - 2004 Study of the molecular mechanism of osteoclast apoptosis.

2003 - 2004 Research for articular cartilage regeneration using overexpression of intracellular signal transduction molecules.

2003 - 2004 外来遺伝子導入によるシュワン細胞分化制御とこれを用いた人工神経の開発についての研

2003 - 2004 運動器疾患におけるユビキチンシステムの関与とその制御に関する研究

2002 - 2004 Study of the therapeutic vaccine approach targeting RANKL.

2001 - 2004 Study of the molecular targeting therapy for rheumatoid arthritis.

2002 - 2003 The Studies Regarding Gene Transfer for the Promotion of Bone Ligament Healing

2002 - 2003 慢性関節リウマチにおける腱断裂機序の解明と治療法の確立

2001 - 2003 Study of the role of TRAF6 on differentiation and activation of the osteoclast.

2000 - 2003 Study of regeneration of peripheral nervous system with adenoviral vectors

2000 - 2002 Involvement of the aging-suppressor gene klotho in the skeletal

2000 - 2001 DEVELOPMENT OF A NEW THERAPEUTC APPROCH TO BONE REGENERATION FOR GENE THERAPY

2000 - 2001 Intracellulan signal : ry pathways involving bone destruction

1998 - 2001 Gene therapy of spinal cord injury by adenovirus vector-mediated gene transduction

1999 - 2000 The Studies towards Inhibition of Joint Adhesion by Decorin Gene Transtection Techrique

1999 - 2000 The Studies towards Prevention of Osteoarthritis of the knee joint Using Adenovirus Vector Encording Hyaluronic Acid Synthe tase Type-2 Gene

1999 - 2000 破骨細胞活性化を制御する細胞内シグナルの研究

1998 - 2000 The Studies Regarding Gene Transfer for the Ligament Healing with Adenovirus Vector

1997 - 2000 Study on adenovirua vector-mediated gene therapy as a therapeuticc approach for bone diseases

脊髄損傷の治療

骨関節破壊の遺伝子治療

骨軟骨の再生

脊髄損傷の遺伝子治療

骨吸収の分子メカニズムの研究

Treatment of spinal cord injury

regeneration of bone and cartilage

Gene therapy of bone and joint destruction

Regeneration of bone and cartilage

Gene therapy of spinal cord injury

Study on mechanism of bone destruction in arthritis

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Papers (461)：

So Kato, Sayaka Fujiwara, Nozomu Ohtomo, Yukimasa Yamato, Katsuyuki Sasaki, Jim Yu, Toru Doi, Yuki Taniguchi, Yoshitaka Matsubayashi, Tomohiro Ushikubo, et al. Motion Capture-based 3-dimensional Measurement of Range of Motion in Patients Undergoing Cervical Laminoplasty. Clinical spine surgery. 2024
Yoshiya Tanaka, Satoshi Soen, Shintaro Hirata, Yosuke Okada, Saeko Fujiwara, Ikuko Tanaka, Yuriko Kitajima, Takuo Kubota, Kosuke Ebina, Yuichi Takashi, et al. The 2023 Guidelines for the management and treatment of glucocorticoid-induced osteoporosis. Journal of bone and mineral metabolism. 2024
Ryutaro Takeda, Hiroyasu Mizuhara, Akihiro Uchio, Toshiko Iidaka, Kenta Makabe, Taro Kasai, Yasunori Omata, Noriko Yoshimura, Sakae Tanaka, Takumi Matsumoto. Automatic estimation of hallux valgus angle using deep neural network with axis-based annotation. Skeletal radiology. 2024
Naohiro Tachibana, Nobuaki Michihata, Takeshi Oichi, Kosei Nagata, Hideki Nakamoto, Nozomu Ohtomo, Yuichi Yoshida, Koji Nakajima, Junya Miyahara, So Kato, et al. Postoperative Complications of Surgery for Cervical Spondylotic Myelopathy with and Without Athetoid Cerebral Palsy. Global Spine Journal. 2024
Satoshi Oka, Akitoshi Ogawa, Takahiro Osada, Masaki Tanaka, Koji Nakajima, Koji Kamagata, Shigeki Aoki, Yasushi Oshima, Sakae Tanaka, Eiji Kirino, et al. Diurnal variation of brain activity in the human suprachiasmatic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024

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MISC (426)：

谷口優樹, 松林嘉孝, 加藤壯, 大島寧, 田中栄. Spinal deformity in Marfan syndrome. 関節外科. 2023. 42. 4
谷口優樹, 谷口優樹, 松林嘉孝, 加藤壯, 大島寧, 田中栄, 池田敏之, 岡崎仁, 深柄和彦. 脊椎手術における完全自己血由来フィブリン糊の使用成績. 医療機器学. 2023. 93. 2
松村雅仁, 大和志匡, 游敬, 加藤壯, 谷口優樹, 松林嘉孝, 大島寧, 田中栄. 脊柱側弯症術後にRod折損を2度生じたGorham-Stout syndromeの1例. 関東整形災害外科学会雑誌. 2023. 54. 2
松林嘉孝, 谷口優樹, 加藤壯, 大友望, 田中栄, 大島寧. Clinical results of unilateral total facetectomy without instrumentation for spinal tumors. Journal of Spine Research (Web). 2023. 14. 3
大友望, 加藤壯, 佐々木克幸, 大和志匡, 游敬, 游敬, 永田向生, 土肥透, 谷口優樹, 松林嘉孝, et al. Comparison between laminectomy and fenestration for lumbar spinal canal stenosis with spinal epidural lipomatosis-Multicenter research-. Journal of Spine Research (Web). 2023. 14. 3

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Books (6)：

Skeletal Biology and Medicine: Aspects of Bone Morphogensis and Remodeling
New York Academy of Sciences 2008 ISBN:1573316849
人工膝関節置換術〈TKA〉のすべて安全・確実な手術のために
メジカルビュー社 2007 ISBN:9784758310208
新骨の科学
医歯薬出版 2007 ISBN:4263456092
Osteoimmunology (Advances in Experimental Medicine and Biology)
Springer-Verlag 2007 ISBN:0387720081
Skeletal Development and Remodeling in Health, Disease, and Aging
New York Academy of Sciences 2006 ISBN:1573315834

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Education (4)：

- 1996 The University of Tokyo
- 1996 The University of Tokyo Graduate School, Division of Medicine
- 1987 The University of Tokyo Faculty of Medicine School of Medicine
- 1987 The University of Tokyo Faculty of Medicine

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (2)：

2023/04 - 現在 The University of Tokyo Hospital Director
2012/01 - 現在東京大学大学院医学系研究科外科学専攻整形外科学教授

Committee career (6)：

2007 - - 日本リウマチ学会 Modern Rheumatology編集委員会
2007 - - 日本整形外科学会学会誌編集委員会
2005 - - 日本整形外科学会専門医試験委員会
2005 - - 日本整形外科学会学術用語委員会
日本リウマチ学会評議員リウマチ専門医リウマチ指導医

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Awards (12)：

2018 - F1000Prime Awards: Faculty Member of The Year (RHEUMATOLOGY & CLINICAL IMMUNOLOGY)
2017 - F1000Prime Awards: Faculty Member of The Year (RHEUMATOLOGY & CLINICAL IMMUNOLOGY)
2011 - 日本骨粗鬆症学会研究奨励賞
2010 - BONE Top Reviewer 2009-2010
2003 - 東日本整形災害外科学会学術集会奨励賞

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Association Membership(s) (5)：

日本分子生物学会 , 日本リウマチ学会 , 日本骨代謝学会 , アメリカ骨代謝学会(American society for bone and mineral research) , 日本整形外科学会

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