Hotta Yoshihiro

2015 - 2018 3D-analysis using biometric technology and the database construction for elucidating the pathological mechanism with congenital cataract

2014 - 2017 Development of genetic diagnosis for Japanese Retinitis Pigmentosa patients using next generation sequencer

2013 - 2017 Investigation of a new mechanism of age-related macular degeneration using a rat model of retinal photic injury: targeted exome analysis for a responsible genomic region

2013 - 2015 The development and clinical application of EYS gene mutation diagnosis in Japanese Retinitis pigmentosa patients

2011 - 2013 Investigation for the genetic factor of glaucoma in another viewpoint: an analysis of possible involvement of copy number variation (CNV) in genome

2011 - 2013 Genetic Diagnosis System for Retinitis Pigmentosa Patients: Large-scale collection and mutation analyses of Japanese RP patients

2011 - 2012 Genotype-phenotype analysis and prevalence study of disease-causing mutations in the EYS gene among Japanese patients with retinitis pigmentosa

2010 - 2012 Identification of candidate genes responsible for an increased susceptibility of age-related macular degeneration using an animal model and its application to gene diagnosis.

2005 - 2009 Exploration of disease-causative and -associated genes and prospect of novel molecular/cellular phenomenon

2005 - 2007 Establishment of immortalized culture-cells derived from cone and rod photoreceptors and construction of in vitro model system of retinal diseases

2002 - 2003 Study of pathophysiology and treatment of superior oblique palsy.

2002 - 2003 Analysis of pathology in usher syndrome by method of molecular biology.

2000 - 2001 Molecular genetic analysis of hereditary retinal diseases

1998 - 2000 A study concerning the association between genotype and phenotype in the inherited ocular diseases

1996 - 1998 Analysis of gene mutations in retinal dystrophies

1995 - 1996 Molecular biological study of corneal dystrophy

1993 - 1995 Candidate gene approach of retinitis pigmentosa

1993 - 1994 Candidate gene approach in corneal degenerations

1989 - 1990 DNA Diagnosis of X-linked Chorioretinal Degenerations

眼科領域の遺伝学

眼科領域の難病に対する新しい治療法

網膜変性の候補遺伝子アプロ-チ

角膜変性症の候補遺伝子アプロ-チ

New therapy for the ocular incurable diseases

Candidate gene approach for retinal degenerations

Candidate gene approach for corneal dystrophies