Research field (3)：
Surgical dentistry
, Experimental pathology
, Human pathology
Research theme for competitive and other funds (53)：
2021 - 2024 Development of innovative lymphatic drug delivery system for distant metastasis treatment
2019 - 2022 Elucidation of the mechanism of lung metastasis activation by lymph node dissection for oral cancer and development of the preventive methods
2017 - 2019 Development of a new radiotherapy using targeted nanobubbles and ultrasound for metastatic lymph nodes
2016 - 2019 Identification of microRNAs associated with distant metastasis in model mouse
2016 - 2018 Treatment for lymph node metastasis of oral cancer by using lymphatic administration of anticancer agent-encapsulated liposomes
2015 - 2018 Study on development of a novel remedy by antioxidative functions of green tea catechin for Sjogren's syndrome
2015 - 2018 High-frequency ultrasound diagnostic imaging system to detect niche formation in the lymph nodes in a pre-metastatic phase
2015 - 2017 Development of radio-chemotherapy using lymphogenous drug delivery for lymph node metastasis of oral cancer
2014 - 2017 Development of early diagnosis and treatment for lymph node metastasis
2014 - 2017 Development of detection and mapping system for the micrometastatic lymph nodes in oral cancer by using contrast-enhanced high-frequency ultrasound imaging
2014 - 2017 Elucidation of the mechanism of radiation damage enhancement using collagen disease model mouse
2013 - 2017 Development of volume registration method for diagnosis of metastatic lymph node of head and neck cancer by ultrasound imaging
2014 - 2016 Minimally invasive therapy for the lymph node metastasis of oral cancer using the gold nanoparticles and near-infrared light
2013 - 2016 Diagnostic system using a high-frequency ultrasound with contrast agent to distinguish cancerous area from keratotic lesion of oral mucosa
2013 - 2016 Drug delivery system using nano-microbubbles and ultrasound applicable to a gene therapy for temporomandibular joint ankylosis
2012 - 2015 Development of alveolar bone regenerative therapy using nano/microbubbles with IGF-I plasmid gene.
2012 - 2015 Development of real-time image analysis system of cervical lymph node network using nanobubbles
2012 - 2014 Experimental study towards the development of lymphatic drug delivery system for the treatment of cervical lymph node metastasis
2011 - 2013 Development of the novel approaches to diagnose and treat head and neck cancer using nanotechnology
2010 - 2012 Development of imaging diagnosis system for oral cancer utilizing lesion-integrated nanobubbles and high frequency ultrasound
2010 - 2012 Study on development of a novel remedy using green tea catechin for Sjogren's syndrome
2009 - 2012 An experimental study for developments of a 4D-imaging system and a novel gene therapy for the hemangioma using nanobubbles and ultrasound
2010 - 2011 Development of study model and medical treatment procedure for the FGFR2-related craniosynostosis syndromes
2009 - 2011 An experimental study for development of real time diagnosis system for oral cancer treatment using nanobubbles and ultrasound
2009 - 2011 An experimental study for a novel gene therapy for the highly malignant tumor of salivary gland using nanobubbles and ultrasound
2007 - 2009 An imaging and drug delivary system for treatment of oral cancer by using ultrasound and nano-bubbles
2007 - 2008 A feasibility study for the treatment of oral cancer using a new drug delivery system and cell inhibitor
2007 - 2008 A feasibility study for a new vaccination system using Nanobubbles and ultrasound
2006 - 2007 A genetic mode of regulation for the growth correlation of mandible and craniomaxilla
2005 - 2007 ROLES OF SALIVARY GLAND CELLS AS ANTIGEN PRESENTING CELLS IN PATHOGENESIS OF SJOGRENS SYNDROME
2005 - 2006 Experimental study for development of microbubble applicable to clinical use in oral cancer chemotherapy
2005 - 2006 口腔癌病巣集積型マイクロバブルの開発と治療への応用
2003 - 2005 Genetic and histopathological characterization of a novel arthritis model resembling rheumatoid arthritis with temporomandibular joint lesion
2003 - 2005 Radiographic and histopathologic study on morphologic changes of mandibular condyle in ovariectomized cynomolgus monkey
2003 - 2004 Feasibility study for an evaluation system of effect and side effect of chemotherapy for oral cancer based on the DPD expression
2002 - 2004 INVOLVEMENT OF APOPTOTIC PATHWAY IN PATHOGENESIS OF SJOGRENS SYNDROME
2002 - 2003 新しいシェーグレン症候群モデル動物の樹立とその遺伝子解析
2001 - 2003 Evaluation of the jaw and periodontal tissues induced hy ovariectomy in the cynomolgus monkeys with osteoporosis.
2001 - 2002 Feasibility study for an evaluation system of effect and side effect chemotherapy for oral cancer utilizing time PCR
2000 - 2002 Genetic analysis of the susceptibility loci associated with carcinogenesis, invasion and metastasis of oral squamous cell carcinoma and establishment of an evaluation system for the carcinoma based on the genetic information
2000 - 2001 Investigation of c-fos and preprodynorphin induced by noxicious stimulation on tooth
1999 - 2001 Establishment of animal model for Sjogren's syndrome and genetic analysis of the susceptibility loci
1999 - 2000 A possible evaluation system for effect of oral cancer chemotherapy based on the grading of apoptotic changes in the carcinoma cells
1998 - 1999 An evaluation system of distant metastasis of oral squamous cell carcinoma according to the biological alterations in the course of cancer treatment
1997 - 1998 歯痛による脳内c-fos発現に関する研究
1996 - 1997 Detection of micrometastases of oral squamous cell carcinoma in regional lymph nodes by using RT-PCR for amplification of cytokeratin 19 mRNA.
1996 - 1997 Evaluation system of chemotherapy and/or radiotherapy for patients with oral squamou cell carcinoma according to the histochemical grading
1995 - 1996 口腔扁平上皮癌の転移の予測のための組織化学的診断システムの開発
1994 - 1995 Regulation of bone morphogeretic protein activity by additional cytokines
1993 - 1994 A role of lymphocytes and cytokines in the osteogenesis induced by bone morphogenetic proteins.
1992 - 1992 口腔扁平苔癬の病因解析に関する免疫学的検討
1991 - 1992 Bone formation by bone morphogenetic proteins under immune disorders
Takagi K, Sukhbaatar A, Mori S, Kodama T. A combination of lymphatic drug delivery of anti-CTLA-4 antibody and local radiotherapy for solid-tumor treatment. Cancer Science. 2024
Ariunbuyan Sukhbaatar, Shiro Mori, Tsuyoshi Sugiura, Tetsuya Kodama. Docetaxel administered through a novel lymphatic drug delivery system (LDDS) improved treatment outcomes for lymph node metastasis. Biomedicine & Pharmacotherapy. 2024. 171. 116085-116085
岩間 亮介, スフバートル・アリウンブヤン, 黒羽根 壮, 梶田 倫功, 纐纈 衆, 森 士朗, 小玉 哲也. CDDPによるリンパ行性がん化学療法における薬剤溶媒特性のリンパ節転移治療へ及ぼす影響(Efficacy of a Drug Delivery System Against Lymph Node Metastases with Physicochemically Modificated Cisplatin). 日本癌学会総会記事. 2023. 82回. 324-324
スフバートル・アリウンブヤン, 纐纈 衆, 宮下 仁, 森 士朗, 杉浦 剛, 小玉 哲也. リンパ行性薬剤送達法の開発のための諸臓器所解剖学的解析ンパネットワークマウスモデルの病理(Physioanatomical analysis of mouse lymphatic network for the lymphatic drug delivery system usage). 日本癌学会総会記事. 2023. 82回. 503-503
鈴木健大, 佐藤琢磨, アリウンブヤン スフバートル, 阪本真弥, 森士朗, 小玉哲也, 伊藤明宏. The combination of vesical instillation of chemotherapy with ultrasound and nanobubbles is efficient against experimental tumors in murine bladder cancer model. 日本泌尿器科学会総会(Web). 2023. 110th
田代和樹, 三浦桂一郎, 宮下仁, 梶田倫功, 武田裕利, 纐纈衆, 佐藤舜, 森士朗, 野上晋之介, 山内健介, et al. A clinical analysis of oral metastatic malignant tumors from other organs. 日本口腔腫瘍学会総会・学術大会プログラム・抄録集. 2022. 40th
Enhancing the therapeutic effect of X-ray irradiation on metastatic lymph nodes through the induction of magnetosome@RGD
(Interface Summer Seminar 2024 (The 19th International Workshop on Biomaterials in Interface Science) 2024)
- 1987 Tohoku University Graduate School, Division of Dental Research 歯学臨床系
Professional career (1)：
歯学博士 (Tohoku University)
Work history (1)：
1988/04 - 1990/04 NIH, NIAID, USA
Committee career (1)：
2016/01 - 2021/12 日本癌学会 評議員
Awards (1)：
2011/03 - 米国歯科研究学会(American Association for Dental Research; AADR) 米国歯科研究学会(American Association for Dental Research; AADR)より、最優秀論文賞2011 William J. Gies賞 Periodontal gene transfer by ultrasound and nano-/microbubbles(ナノバブルと超音波を用いた歯周組織への遺伝子導入)
