Ishikawa Tetsuya

Homepage URL (1)： http://patho-sci.la.coocan.jp/environ.html

Research field (3)： Immunology , Virology , Gastroenterology

Research theme for competitive and other funds (29)：

2022 - 2025 トリプトファン代謝制御を利用した慢性HBV感染症に対する治療的ワクチン療法の開発
2022 - 2025 妊娠期・授乳期糖質制限が次世代に及ぼす影響-糖質配合比および糖質制限時期の検討ー
2021 - 2024 Establishment of a liver regeneration treatment model based on cell transplantation and development of a new treatment against immune rejection.
2020 - 2023 HBs抗原陰性化に関わるB型肝炎ウイルス変異と腸内細菌叢が及ぼす免疫応答の解明
2020 - 2023 Development of novel hepatitis B molecular immunotherapy for integrated control of virus and carcinogenesis

2019 - 2022 Development of therapeutic vaccine therapy using chronic HBV infection model

2017 - 2022 Development of therapy for hepatitis B based on immuno-omics research

2017 - 2020 Development of method to eliminate nuclear HBV cccDNA by activating adaptive immune response

2016 - 2019 Development of an HBV infection mouse model using HSV-TK-WT mouse

2016 - 2019 Monitoring of transplanted hepatocytes and analysis of immune rejection responses in the hepatocyte chimeric mouse system.

2014 - 2018 In vivo imaging of transplanted stem cells by OTN-NIR fluorescence quantum dots

2013 - 2018 In vivo Theranostics with quantum switching for iPS cell differentiation and carcinogenesis

2012 - 2017 Development of new immunotherapeutic drug aiming at control and elimination of HBV ccc DNA

2012 - 2017 Study on development of efficient culture cell evaluation systems that reproduce persistent infection of hepatitis B virus

2012 - 2015 Basic investigation for new cytotherapy in animal model for immune mediated fulminant hepatitis.

2011 - 2013 Analysis of immune and metabolic responses of liver cells under inflammatory circumstances or viral infection

2006 - 2007 Investigation of novel therapeutic approach through regulatory T cells (Tr) and dendritic cells (DCs) for the patients with autoimmune hepatitis (AIH)

2005 - 2006 Analysis and therapeutic application of crosstalk between innate immunity and acquired immunity in viral hepatitis.

2004 - 2005 Roles of regulatory T cells (Tr) and dendritic cells (DCs) in the pathogenesis of autoimmune hepatitis(AIH)

2003 - 2005 Identification and clinical application for the role of NKT cells in patients with chronic hepatitis and hepatocellualr carcinoma infected hepatitis virus

2003 - 2004 Analysis for the kinetics of host gene expression in the progression or recovery process of hepatic inflammation.

2002 - 2003 Establishment of murine model for auto immune hepatitis (AIH)

2000 - 2001 To clarify the mechanism of chronicity and to explore therapeutic approach for viral hepatitis

1998 - 2000 Pathologicl significance and its inhibition of apoptosis on the development and its progression of liver injury.

1998 - 1999 IMMUNO-PATHOGENESIS AND -THERAPY OF INTRACTABLE VIRAL HEPATTIS

1997 - 1998 Biochemical analysis and therapeutic model of persistently infectious virus causing cancer.

1997 - 1997 IMMUNO-PATHOGENESIS AND-THERAPY OF VIRAL HEPATITIS

1996 - 1996 C型肝炎ウイルス・トランスジェニックマウスの作製とその分子生物学的、免疫学的解析

1995 - 1996 Cellular immune response against HBV nucleocapsid antigen

Show all

Papers (103)：

本多隆, 石上雅敏, 石川哲也. B型慢性肝炎患者における免疫要素を加味した機能的治癒(Functional Cure)予測因子としてのコアI97L変異の可能性. 肝臓. 2023. 64. Suppl.1. A352-A352
武藤久哲, 本多隆, 水野史崇, 松田宣賢, 犬飼庸介, 山本崇文, 水野和幸, 横山晋也, 田中卓, 山本健太, et al. Deep proteomicsを用いた高脂肪食摂取マウスにおける腸管透過性亢進メカニズムの検討. 日本消化器病学会雑誌. 2023. 120. 臨増総会. A308-A308
Shota Yamada, Hiroshi Yukawa, Koudai Kitamura, Toshiki Mizumaki, Yasuma Yoshizumi, Tomomi Oohara, Eri Nanizawa, Fumika Hirano, Kazuhide Sato, Ayae Sugawara-Narutaki, et al. In Vivo Real-Time Quantum Dots Imaging to Track Transplanted Adipose Stem Cells in Different Inflammatory States of Acute Liver Failure Mice. Cell transplantation. 2023. 32. 9636897231176442-9636897231176442
Yuki Tamaki, Yuria Shibata, Misaki Hayakawa, Nodoka Kato, Ami Machii, Yuma Ikeda, Eri Nanizawa, Yumi Hayashi, Hiroshi Suemizu, Hiroyasu Ito, et al. Treatment with hepatocyte transplantation in a novel mouse model of persistent liver failure. Biochemistry and biophysics reports. 2022. 32. 101382-101382
Yoshiaki Sugiyama, Yoji Ishizu, Yusuke Ando, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Norihiro Imai, Masanao Nakamura, Takashi Honda, Hiroki Kawashima, et al. An improved method to assess skeletal muscle mass in patients with liver cirrhosis based on computed tomography images. Hepatology research : the official journal of the Japan Society of Hepatology. 2022. 52. 11. 937-946

ｍore...

MISC (465)：

堀純子, 玉置優貴, 内藤沙妃, 柴田ゆりあ, 池田悠馬, 池田悠馬, 名仁澤英里, 林由美, 石川哲也. HBs抗原のヒト肝細胞への取込み機序とその意義について. 日本臨床検査医学会誌. 2021. 69
内藤沙妃, 玉置優貴, 堀純子, 柴田ゆりあ, 池田悠馬, 池田悠馬, 名仁澤英里, 林由美, 石川哲也. 食餌性因子が肝内の免疫・ストレス応答と肝障害感受性に及ぼす影響について. 日本臨床検査医学会誌. 2021. 69
玉置優貴, 堀純子, 内藤沙妃, 柴田ゆりあ, 池田悠馬, 池田悠馬, 名仁澤英里, 林由美, 石川哲也. 肝再生不全マウスに対する肝細胞移植後の肝内環境変化と肝再生との関連について. 日本臨床検査医学会誌. 2021. 69
Takashi Honda, None Yamada, Asako Murayama, Asuka Kato, Takanori Ito, Yoji Ishizu, Teiji Kuzuya, Masatoshi Ishigami, Yoshiki Murakami, Tetsuya Ishikawa, et al. AMINO ACID POLYMORPHISM IN HEPATITIS B VIRUS ASSOCIATED WITH NATURAL CLEARANCE OF HBV DNA AND HBsAg. HEPATOLOGY. 2020. 72. 508A-509A
玉置優貴, 堀純子, 名仁澤英里, 林由美, 石川哲也. 肝細胞キメラマウス作製系における移植肝細胞の生着、拒絶の動態と拒絶回避のための治療について. 臨床病理. 2020. 68. 補冊. 193-193

ｍore...

Lectures and oral presentations (32)：

肝細胞キメラマウス作製系における移植肝細胞の生着、拒絶の動態と拒絶回避のための治療について
(第67回日本臨床検査医学会学術集会 2020)
腫瘍肝占拠率50%以上の高度進行肝細胞癌に対する分子標的治療薬の治療効果の検討~ソラフェニブとレンバチニブの比較~
(第56回日本肝臓学会総会 2020)
肝細胞移植後の肝再生過程における肝内環境変化とその役割について
(第42回日本炎症・再生医学会 2020)
高脂肪食負荷マウスにおける肝障害重症化機序についての解析
(第59回日本臨床検査医学会東海・北陸支部総会、第340回日本臨床化学会東海・北陸支部例会 2020)
肝細胞キメラマウス作製系における細胞移植後の免疫拒絶応答の解析
(第59回日本臨床検査医学会東海・北陸支部総会、第340回日本臨床化学会東海・北陸支部例会 2020)

ｍore...

Education (2)：

1989 - 1995 Nagoya University Graduate School of Medicine Internal Medicine 3
1979 - 1985 Nagoya University School of Medicine

Professional career (1)：

Medical Science (Nagoya University)

Work history (11)：

2020/04 - 現在 Nagoya University Graduate School of Medicine Lab. of Biomolecular Sciences, Div. of Omics Health Sciences, Dept. of Integrated Health Sciences Professor
2018/10 - 現在 Nagoya University Institute of Nano-Life-Systems, Institutes of Innovation for Future Society
2012/04 - 2020/03 Nagoya University Graduate School of Medicine Div. of Medical Technology, Dept. of Radiological & Medical Laboratory Sciences Professor
2010/04 - 2012/03 Nagoya University School of Medicine Div. of Laboratory Medicine, Dept. of Health Sciences Professor
2007/11 - 2010/03 Nagoya Kyoritsu Hospital Center of Immune Cell Therapy Director

Show all

Association Membership(s) (11)：

The Japanese Society of Inflammation and Regeneration , The Asian Pacific Association for the Study of the Liver , The Japanese Society for Regenerative Medicine , The Japanese Society of Laboratory Medicine , Japan Society of Clinical Oncology , Japanese Cancer Association , The Japanese Society for Virology , The Japanese Society for Immunology , The Japan Society of Hepatology , The Japanese Society of Internal Medicine , The Japanese Society of Gastroenterology

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page