Numoto Nobutaka

ヌモトノブタカ | Numoto Nobutaka

Affiliation and department：
Job title： Special-Appointment Associate Professor

Research field (1)： Structural biochemistry

Research theme for competitive and other funds (7)：

2018 - 2020 B細胞抑制性因子CD72による自己抗原の特異的認識機構の解明
2015 - 2016 巨大ヘモグロビン結晶中での酸素結合飽和度の同定と時分割構造解析
2013 - 2014 巨大ヘモグロビンにおける協同的酸素結合過程の逐次構造解析
2004 - 2009 Structure and organization of nano-sized giant hemoglobin
クチナーゼCut190のCa2+結合に伴う動的構造変化とPET分解分子機構の解明

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Papers (60)：

Mutsumi Yoshida, Yuya Hanazono, Nobutaka Numoto, Satoshi Nagao, Saaya Yabuno, Yumi Kitagawa, Hiroshi Sekiguchi, Nobutoshi Ito, Takachika Azuma, Masayuki Oda. Affinity-matured antibody with a disulfide bond in H-CDR3 loop. Archives of Biochemistry and Biophysics. 2024. 758. 110068-110068
Chizuru Akatsu, Takahiro Tsuneshige, Nobutaka Numoto, Wang Long, Toshio Uchiumi, Yoshikatsu Kaneko, Masatake Asano, Nobutoshi Ito, Takeshi Tsubata. CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody. Journal of autoimmunity. 2024. 146. 103245-103245
Gert-Jan Bekker, Nobutaka Numoto, Maki Kawasaki, Takahiro Hayashi, Saaya Yabuno, Yuko Kozono, Takeyuki Shimizu, Haruo Kozono, Nobutoshi Ito, Masayuki Oda, et al. Elucidation of binding mechanism, affinity and complex structure between mWT1 tumor-associated antigen peptide and HLA-A*24:02. Protein Science. 2023
Akiko Kamegawa, Shota Suzuki, Hiroshi Suzuki, Kouki Nishikawa, Nobutaka Numoto, Yoshinori Fujiyoshi. Structural analysis of the water channel AQP2 by single-particle cryo-EM. Journal of structural biology. 2023. 215. 3. 107984-107984
Daisuke Kozai, Nobutaka Numoto, Kouki Nishikawa, Akiko Kamegawa, Shohei Kawasaki, Yoko Hiroaki, Katsumasa Irie, Atsunori Oshima, Hiroyuki Hanzawa, Kousei Shimada, et al. Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human α2δ1, a Voltage-Gated Calcium Channel Subunit. Journal of molecular biology. 2023. 435. 10. 168049-168049

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MISC (46)：

Nobutaka Numoto. Structure Determination from Protein Crystal Clusters by Fully Automatic Data Collection. Journal of the Crystallographic Society of Japan. 2021. 63. 3
Oda M, Numoto N, Bekker GJ, Kamiya N, Kawai F. Cutinases from thermophilic bacteria (actinomycetes): from identification to functional & structural characterization. Methods Enzymol. 2021. 159-185
Numoto N, Kamiya N, Kawai F, Oda M. Crystal Structures of Polyethylene Terephthalate-Degrading Enzyme Cut190 in Substrate-Bound States Reveal the Enzymatic Reaction Cycle Accelerated by Calcium Ion. ACS Symposium Series "Green Polymer Chemistry and Sustainability.". 2021
清水奏, 宮下由里奈, 松尾直也, 中野祥吾, 伊藤創平, 沼本修孝, 伊倉貞吉, 伊藤暢聡, 加来田博貴, 常盤広明. hRXRαリガンドCBt-PMNのパーシャルアゴニスト活性の起源は何か?. 日本薬学会年会要旨集. 2018. 138年会. 2. 111-111
沼本修孝, 細江雄飛, 稲葉理美, 稲葉理美, 小川修平, 森井尚之, 安部良, 織田昌幸, 伊藤暢聡. シグナル伝達分子Grb2 SH2ドメインとCD28由来ペプチド複合体の水素原子の可視化を目指した高分解能結晶構造解析. メディシナルケミストリーシンポジウム講演要旨集. 2018. 36th

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Books (1)：

Crystallography in Japan (II)
Crystallographic Society of Japan 2014 ISBN:9784990386122

Lectures and oral presentations (71)：

Molecular mechanism of self-antigen recognition by the ligand binding domain of B cell inhibitory co-receptor CD72
(25th Congress and General Assembly of the International Union of Crystallography 2021)
A user review of automatic and remote measurement at SPring-8
(59th SPring-8 Advanced Utilization Technology Workshop / IPR Seminar 2021)
A user review of automatic and remote measurement at SPring-8
(Webinar on Annual Meeting 2020 and General Assembly of Crystallographic Society of Japan 2020)
Structure determination from cluster crystals of an inhibitory B cell co-receptor CD72
(Annual Meeting 2020 and General Assembly of Crystallographic Society of Japan 2020)
Structural and characteristics analysis of intracellular signal transduction protein PI3K SH2
(The 56th Japan Conference Calorimetry and Thermal Analysis 2020)

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Education (3)：

2001 - 2004 Kyoto University Graduate School, Division of Natural Science
1999 - 2001 Kyoto University Graduate School, Division of Natural Science
1995 - 1999 Kyoto University Faculty of Science

Professional career (1)：

Ph.D. (Kyoto University)

Work history (8)：

2024/01 - 現在 Okayama University International Center for Structural Biology, Research Institute for Interdisciplinary Science Special-Appointment Associate Professor
2021/06 - 2023/12 Tokyo Medical and Dental University Medical Research Institute Advanced Molecular Medicine Structural Biology Associate Professor
2012/10/01 - 2021/05/31 Tokyo Medical and Dental University Medical Research Institute Advanced Molecular Medicine Structural Biology Assistant Professor
2012/10 - 2021/05 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Life Science and Technology Life Science and Technology Structural Biology Assistant Professor
2010/02/01 - 2012/09/30 Kyoto University Research Reactor Institute

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Committee career (6)：

2016/09 - 現在 SPring-8ユーザー協同体(SPRUC)放射光構造生物学研究会幹事
2020/04 - 2022/04 日本学術振興会産学協力委員会 R022 量子構造生物学委員会個人会員(学界委員)
2020/04 - 2022/03 日本結晶学会編集幹事
2018/04 - 2020/03 日本結晶学会編集委員
2018/01 - 2019/01 日本生物物理学会分野別専門委員

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Awards (3)：

2017/03 - 平成28年度難治疾患研究所最優秀論文賞 CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous Toll-like receptor 7 ligand Sm/RNP
2011/09 - 日本磁気科学会日本磁気科学会研究奨励賞磁気力場中でのタンパク質結晶化
2010/12 - 日本結晶学会日本結晶学会進歩賞巨大ヘモグロビンとV型ATPaseの構造と機能に関する結晶学的研究

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