Ishii Hidemi

• 抗血栓薬の開発研究
• 血栓症の機序解明
• 癌細胞の転移機構における血液凝固線溶系の関与
• 血管内皮細胞の血液凝固調節機構
• Developmental research of antithrombosis drug
Developmental mechanisms of thrombosis
Participation of Blood Coagulation and Fibrinolysis Systems on Metastasis of Cancer Cells
Mechanisms of Blood Coagulation Control by Vascular Endothelial Cells

• Bo-Kyung Son, Masahiro Akishita, Katsuya Iijima, Sumito Ogawa, Tomio Arai, Hidemi Ishii, Koji Maemura, Hiroyuki Aburatani, Masato Eto, Yasuyoshi Ouchi. Thrombomodulin, a novel molecule regulating inorganic phosphate-induced vascular smooth muscle cell calcification. Journal of molecular and cellular cardiology. 2013. 56. 72-80
• Nobuko Yoshimoto, Tomoyuki Sasaki, Katsuyoshi Sugimoto, Hidemi Ishii, Keiko Yamamoto. Design and Characterization of a Selenium-Containing Inhibitor of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa), a Zinc-Containing Metalloprotease. JOURNAL OF MEDICINAL CHEMISTRY. 2012. 55. 17. 7696-7705
• Yutaka Masuda, Dan Saotome, Kimihiko Takada, Katsuyoshi Sugimoto, Tomoyuki Sasaki, Hidemi Ishii. Peroxisome proliferator-activated receptor-alp la agonists repress expression of thrombin-activatable fibrinolysis inhibitor by decreasing transcript stability. THROMBOSIS AND HAEMOSTASIS. 2012. 108. 1. 74-85
• ISHII Hidemi. Intravenous and oral administration of DD2 [7-amino-2- (sulfaniylmethyl)pentanoic acid] produce thrombolysis through inhibition of plasma TAFIa in rats with tissue factor-induced microthrobosis. Thromb. Res. 2012. 130. 4. E222-E228
• Yoshio Nakagawa, Toshinari Suzuki, Hidemi Ishii, Akio Ogata, Dai Nakae. Mitochondrial dysfunction and biotransformation of beta-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes. CHEMICO-BIOLOGICAL INTERACTIONS. 2010. 188. 3. 393-403

ｍore...

• 衛生薬学. 朝倉書店. 2005
• 図説 血栓・止血・血液学-血栓症制圧のために. 中外医学社. 2005
• 環境衛生辞典. 丸善. 2005
• TAFIと血栓症. 別冊 医学のあゆみ Vol 3. 血液疾患 State of Arts. 2005. 299-302
• 血液の事典 トロンビン活性化線溶阻害因子. 朝倉書店. 2004

ｍore...

• 衛生薬学 第3版
  朝倉書店 2013
• 健康と環境
  東京化学同人 2006
• 図説 血栓・止血・血液学
  中外医学社 2005
• 血液・造血器疾患に対する薬物の選択と使用
  薬理学マニュアル 2002
• 病態生理学
  朝倉書店 2001

ｍore...

• Thrombin-activatable fibrinolysis inhibitor (TAFI)の研究
  石井 秀美 2000 -
• 血液凝固(]G0007[)因子の研究
  2000 -
• Study on factor (]G0007[)
  2000 -
• 動脈硬化巣における血栓形成の機序
  1998 -
• Developmental mechanisms of thrombosis in atherosclerosis lesion
  1998 -

ｍore...

• - 1976 Tokyo University of Pharmacy and Life Sciences
• - 1976 Tokyo University of Pharmacy and Life Science Graduate School, Division of Pharmaceutical Sciences
• - 1970 Tokyo University of Pharmacy and Life Sciences School of Pharmacy School of Pharmacy
• - 1970 Tokyo University of Pharmacy and Life Science Faculty of Pharmaceutical Science

• (BLANK) (Tokyo University of Pharmacy and Life Science)
• (BLANK) (Kyoto Prefectural University of Medicine)

• 1982 - 1996 Teikyo University Faculty of Pharma-Science
• 1982 - 1996 Associate Professor in Faculty of
• 1996 - Showa Pharmaceutical University
• 1996 - - Professor, Showa Pharmaceutical University
• 1984 - 1986 ワシントン大学医学部 研究員
1984 - 1986 Associate Researcher, School of Medicine,
1979 - 1982 Teikyo University Faculty of Pharma-Science
1979 - 1982 Assistant Professor in Faculty of
1976 - 1979 Tokyo University of Pharmacy and Life Sciences
1976 - 1979 Assistant in Tokyo University of Pharmacy and
Wasington University
Pharmaceutiocal Sciences Teikyo University
Pharmaceutical Sciences Teikyo University
Life Sciences

• 2010 - 現在 日本薬学会生物系薬学部会常任世話人
• 2007 - 2010 日本高等教育評価機構評価員
• 1999 - 2010 三菱生命科学研究所倫理委員会
• 2001 - TTMフォーラム 世話人
• 1999 - 日本薬学会 代議員
1993 - Pharmaco-Hematology研究会 事務局長,代表世話人
1992 - 日本血液学会 評議員
1990 - 日本血栓止血学会 編集委員,評議員,庶務幹事
The Pharmacuetical Society of Japan a representative
The Japanese Society for Laboratory Hematology a councilor
The Japanese Society of Thrombosis and Hemostasis a councilor
The Japanese Society of Hematology a councilor

PAI-1研究会 ,  Pharmaco-Hematology研究会 ,  日本生化学会 ,  日本薬学会 ,  国際血栓止血学会(International Society of Thrombosis and Hemostasis) ,  日本血液学会 ,  日本血栓止血学会 ,  The Japanesee Association for Metastasis Research ,  The Pharmacuetical Society of Japan ,  The Japanese Biochemical Society ,  The International Sciety on thrombosis and Haemostasis ,  The Japanese Society for Laboratory Hematology ,  The Japanese Society of Thrombosis and Hemostasis ,  The Japanese Society of Hematology