Ishikawa Tomohisa

イシカワトモヒサ | Ishikawa Tomohisa

Affiliation and department：
Homepage URL (1)： https://w3pharm.u-shizuoka-ken.ac.jp/pharmaco/

Research field (2)： Nutrition and health science , Pharmacology

Research keywords (6)：肝線維症 , hepatic stellate cell , diabetes , pancreatic β cells , lipid metabolism , insulin secretion

Research theme for competitive and other funds (24)：

2024 - 2027 ヒト呼気中揮発性有機物の構成解析に基づく肝線維化簡易診断法の確立に向けた基盤研究
2023 - 2026 肥満誘発β細胞代償性増殖ブレーキの解除を活用した脂質分子による血糖調節戦略の構築
2023 - 2026 肝星細胞における液-液相分離を標的としたNASH進行スイッチ制御の確立
2021 - 2024 AI搭載ガスクロマトグラフを応用した呼気分析によるNASH進行非侵襲判定法の開発
2020 - 2023 細胞内脂質シグナルを標的としたβ細胞量増大による糖尿病治療の確立に向けた検証研究

2020 - 2023 Basic study for developing NASH therapeutic drugs by using a small molecule derived from the cellular slime mold serving as a lead compound

2018 - 2021 Development of disease model in mice on the basis of mechanisms for pathogenesis of gestational diabetes.

2019 - 2021 リコンビナントCytoglobinを用いた脱肝線維化治療薬開発に関する研究

2017 - 2020 Intracellular lipid signaling analysis for the development of novel diabetes therapeutic agents targeting neogenesis and proliferation of pancreatic beta-cells

2017 - 2020 Involvement of DAG metabolism in beta-cell dysfunction during type 2 diabetes

2015 - 2018 Possible involvement of gut-derived melatonin as a negative regulator of insulin secretion

2011 - 2013 Role of crosstalk between peripheral circadian clock and NO-cGMP system of pancreatic beta-cells in the pathogenesis of diabetes

2008 - 2010 Intermolecular network involved in calcium-dependent apoptosis of pancreatic beta-cells and possible targets for diabetes treatment

2006 - 2007 Molecular mechanisms for regulation of glucose metabolism in skeletal muscle cells by biomechanical stress.

2005 - 2007 Roles of TRP channels in response to exposure with high concentrations of glucose in pancreatic β cells

2001 - 2002 Physiological role of NO produced by constitutive NO synthase in pancreatic islet of Langerhans

2000 - 2002 Realtime imaging analysis of tyrosine phosphorylation in response to hemodynamic forces

1999 - 2000 Analysis of intracellular mechanisms contributing to insulin secretion from pancreatic β-cells

1997 - 1998 Contraction-excitation feedback in heart failure and cardiac hypertrophy

1997 - 1998 内皮由来過分極因子の作用メカニズムの解明

1996 - 1998 The role new pepdidergic neuron in autoregulation of regional blood flow.

1995 - 1997 Analysis of dedifferentiation and growth of glial cells in tissue regeneration process after brain damage

1996 - 1996 血管平滑筋弛緩反応におけるイオンチャンネルの関与

1989 - 1989 心臓における第3の神経-CGRP作動性神経-の生理的意義の解明

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Papers (111)：

Takayuki Oguma, Takanori Kanazawa, Yukiko K Kaneko, Ren Sato, Miku Serizawa, Akira Ooka, Momoka Yamaguchi, Tomohisa Ishikawa, Hiromu Kondo. Effects of phospholipid type and particle size on lipid nanoparticle distribution in vivo and in pancreatic islets. Journal of controlled release : official journal of the Controlled Release Society. 2024
Megumi Kaji, Yukiko K Kaneko, Stella Amarachi Ihim, Ran Kanoh, Moe Yamamoto, Momoka Yamaguchi, Tomohisa Ishikawa. Oral ingestion of Shiikuwasha extract suppresses diabetes progression in db/db mice by preserving β-cell mass. Frontiers in nutrition. 2024. 10. 1336133-1336133
Soshiro Kodera, Toshihide Kimura, Tomoki Nishioka, Yukiko K Kaneko, Momoka Yamaguchi, Kozo Kaibuchi, Tomohisa Ishikawa. GDP-bound Rab27a regulates clathrin disassembly through HSPA8 after insulin secretion. Archives of biochemistry and biophysics. 2023. 749. 109789
Mai Kato, Momoka Yamaguchi, Akira Ooka, Ryota Takahashi, Takuji Suzuki, Keita Onoda, Yuko Yoshikawa, Yuta Tsunematsu, Michio Sato, Yasukiyo Yoshioka, et al. Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice. Scientific reports. 2023. 13. 1. 8924-8924
Hirotake Ishida, Tomohisa Ishikawa, Shin-ya Saito. Enhanced Contraction of Arterial Smooth Muscle Cell in Skin Artery Is Sensitive to Hyperpolarization Mediated by BK<sub>Ca</sub> Channel in Chronic Constriction Injury Model Rat. Biological and Pharmaceutical Bulletin. 2023. 46. 3. 399-403

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MISC (95)：

柴田涼吾, 金子雪子, 山口桃生, 森野純鈴, 金沢貴憲, 石川智久. 植物由来エキソソーム様ナノ粒子が膵β細胞アポトーシスに及ぼす影響の検討. 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集. 2023. 2023
芹澤未来, 金沢貴憲, 金沢貴憲, 金子雪子, 佐藤蓮, 大岡央, 山口桃生, 飯岡真吾, 尾熊貴之, 石川智久, et al. 静脈投与による脂質ナノ粒子の膵島分布特性に及ぼすリン脂質および粒子径の影響. 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集. 2023. 2023
森野純鈴, 山口桃生, 岡部磨幸, 河合佑美, 金子雪子, 柴田涼吾, 大岡央, 金沢貴憲, 石川智久. 植物由来エキソソーム様ナノ粒子が肝星細胞の活性化制御および細胞への取り込みに及ぼす影響. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2023. 44th
岡部磨幸, 山口桃生, 大岡央, 森野純鈴, 柴田涼吾, 金沢貴憲, 金子雪子, 石川智久. Effects of plant-derived exosome-like nanoparticles on the activation of hepatic stellate cells. 日本薬学会年会要旨集(Web). 2023. 143rd
柴田涼吾, 金子雪子, 山口桃生, 森野純鈴, 金沢貴憲, 石川智久. 膵β細胞アポトーシスに対する植物由来エキソソーム様ナノ粒子の効果の検証. 次世代を担う若手のための創薬・医療薬理シンポジウムプログラム・要旨集. 2023. 2023

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Books (3)：

学際的創薬科学論-有機化学・薬理・構造生物学・薬物動態・安全性から創
京都廣川書店 2019 ISBN:4909197427
詳解薬理学
廣川書店 2015 ISBN:4567495101
図解薬理学
南山堂 2015 ISBN:9784525720612

Education (3)：

- 1989 University of Tsukuba
- 1986 University of Tsukuba Graduate School, Division of Medicine
- 1984 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy

Professional career (2)：

M.S. (University of Tsukuba)
Ph.D. (University of Tsukuba)

Work history (11)：

2023 - 現在 University of Shizuoka School of Pharmaceutical Sciences
2006 - 現在静岡県立大学薬学部教授
2019 - 2023 静岡県立大学大学院薬学研究院長
2019 - 2021 静岡県立大学大学院薬食生命科学総合学府長
2015 - 2019 University of Shizuoka School of Pharmaceutical Sciences

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Committee career (7)：

2009 - 現在医薬品医療機器総合機構専門委員
2016 - 2024 日本薬理学会研究推進委員会委員
2010 - 2024 薬学共用試験センターシステム検討委員会委員
2021 - 2023 日本薬理学会賞等選考委員会委員
2020 - 2022 日本薬理学会研究推進委員長

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Association Membership(s) (4)：

日本循環薬理学会 , 日本糖尿病学会 , 日本薬学会 , 日本薬理学会

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