Ishikawa Tomohisa

2020 - 2023 細胞内脂質シグナルを標的としたβ細胞量増大による糖尿病治療の確立に向けた検証研究

2020 - 2023 Basic study for developing NASH therapeutic drugs by using a small molecule derived from the cellular slime mold serving as a lead compound

2018 - 2021 Development of disease model in mice on the basis of mechanisms for pathogenesis of gestational diabetes.

2019 - 2021 リコンビナントCytoglobinを用いた脱肝線維化治療薬開発に関する研究

2017 - 2020 Intracellular lipid signaling analysis for the development of novel diabetes therapeutic agents targeting neogenesis and proliferation of pancreatic beta-cells

2017 - 2020 Involvement of DAG metabolism in beta-cell dysfunction during type 2 diabetes

2015 - 2018 Possible involvement of gut-derived melatonin as a negative regulator of insulin secretion

2011 - 2013 Role of crosstalk between peripheral circadian clock and NO-cGMP system of pancreatic beta-cells in the pathogenesis of diabetes

2008 - 2010 Intermolecular network involved in calcium-dependent apoptosis of pancreatic beta-cells and possible targets for diabetes treatment

2006 - 2007 Molecular mechanisms for regulation of glucose metabolism in skeletal muscle cells by biomechanical stress.

2005 - 2007 Roles of TRP channels in response to exposure with high concentrations of glucose in pancreatic β cells

2001 - 2002 Physiological role of NO produced by constitutive NO synthase in pancreatic islet of Langerhans

2000 - 2002 Realtime imaging analysis of tyrosine phosphorylation in response to hemodynamic forces

1999 - 2000 Analysis of intracellular mechanisms contributing to insulin secretion from pancreatic β-cells

1997 - 1998 Contraction-excitation feedback in heart failure and cardiac hypertrophy

1997 - 1998 内皮由来過分極因子の作用メカニズムの解明

1996 - 1998 The role new pepdidergic neuron in autoregulation of regional blood flow.

1995 - 1997 Analysis of dedifferentiation and growth of glial cells in tissue regeneration process after brain damage

1996 - 1996 血管平滑筋弛緩反応におけるイオンチャンネルの関与

1989 - 1989 心臓における第3の神経-CGRP作動性神経-の生理的意義の解明