Tatsuka Masaaki

タツカマサアキ | Tatsuka Masaaki

Affiliation and department：
Job title： Professor
Other affiliations (2)：

Hiroshima University Graduate School of Biomedical Sciences Associate Professor
Hiroshima University Research Institute for Radiation Biology and Medicine Associate Professor

Homepage URL (1)： http://www.pu-hiroshima.ac.jp/~tatsuka/

Research field (6)： Molecular biology , Tumor biology , Systems genomics , Cell biology , Environmental effects of chemicals , Environmental effects of radiation

Research keywords (19)： Radiation biodosimetry , Genome science , Cancer cell biology , Radiation biology , Radiation disaster , RhoGDI , AIM-1 , SAKI , NSUN2 , Chromosomal passenger , Aurora , Cancer metastasis , Radiation , Protein kinase , Small G protein , Chromosome segregation , Cell cycle , Oncogene , Radiation genome systems biology

Research theme for competitive and other funds (20)：

2017 - 2020 Radiation-induced expression of N-terminal-deleted RhoGDIbeta: its biological relevance and applicability of individual radiation-risk assessment
2009 - 2011 予後不良がんの予知と克服を目指したオーロラ関連分子の細胞内ダイナミクス研究
2007 - 2008 次世代バイオドジメトリーの開発研究
2001 - 2003 Mechanisms of apoptotic cell death caused by radiation-induced perturbation in checkpoint regulations.
2001 - 2001 がん細胞のM期染色体分配制御異常発生機構に関する研究

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Papers (117)：

Yuka Sugihara, Xiaoxu Zuo, Takashi Takata, Shengjian Jin, Mutumi Miyauti, Atusi Isikado, Hiromichi Imanaka, Masaaki Tatsuka, Guangying Qi, Fumio Shimamoto. Inhibition of DMH-DSS-induced colorectal cancer by liposomal bovine lactoferrin in rats. ONCOLOGY LETTERS. 2017. 14. 5. 5688-5694
Takahide Ota, Yong-Sheng Jiang, Mamoru Fujiwara, Masaaki Tatsuka. Apoptosis-independent cleavage of RhoGDI beta at Asp19 during PMA-stimulated differentiation of THP-1 cells to macrophages. MOLECULAR MEDICINE REPORTS. 2017. 15. 4. 1722-1726
Mamoru Fujiwara, Mayumi Okamoto, Masato Hori, Hiroshi Suga, Hiroshi Jikihara, Yuka Sugihara, Fumio Shimamoto, Toshio Mori, Koichi Nakaoji, Kazuhiko Hamada, et al. Radiation-Induced RhoGDIβ Cleavage Leads to Perturbation of Cell Polarity: A Possible Link to Cancer Spreading. Journal of Cellular Physiology. 2016. 231. 11. 2493-2505
Ralf Wiedemuth, Barbara Klink, Mamoru Fujiwara, Evelin Schrock, Masaaki Tatsuka, Gabriele Schackert, Achim Temme. Janus face-like effects of Aurora B inhibition: antitumoral mode of action versus induction of aneuploid progeny. CARCINOGENESIS. 2016. 37. 10. 993-1003
Guangying Qi, Yasusei Kudo, Bo Tang, Tian Liu, Shengjian Jin, Jing Liu, Xiaoxu Zuo, Sisi Mi, Wenhuan Shao, Xiaojuan Ma, et al. PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer. Oncotarget. 2016. 7. 14. 18812-24

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MISC (35)：

F. Shimamoto, H. Tuncel, H. Kaneko, H. Jikihara, M. Okamoto, M. Tatsuka. Overexpression of PARP6 is associated with good prognosis in colorectal cancer. FEBS JOURNAL. 2012. 279. 312-312
F. Shimamoto, H. Tuncel, G. Qi, M. Tatsuka. Poly (adenosine diphosphate-ribose) polymerase-6 expression in traditional adenocarcinoma and serrated adenocarcinoma of colorectum. FEBS JOURNAL. 2011. 278. 233-234
F. Shimamoto, H. Tuncel, G. Qi, E. Aoki, T. Takata, M. Tatsuka. Expression of chromosomal passenger protein in thyroid cancer. FEBS JOURNAL. 2010. 277. 183-183
F. Shimamoto, H. Tuncel, G. Qi, E. Aoki, T. Takata, M. Tatsuka. Expression of survivin in serrated polyps of the large intestine. FEBS JOURNAL. 2009. 276. 255-255
F. Shimamoto, H. Tuncel, G. Qi, E. Aoki, T. Takata, M. Tatsuka. Cytoplasmic localization of survivin is implicated in lymphnode metastasis of colorectal cancer patients. FEBS JOURNAL. 2007. 274. 359-359

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Patents (9)：

M期キナーゼ基質タンパク質及びその利用
電離放射線の被曝量測定方法
タンパク質、核酸、ベクター、宿主細胞、タンパク質の生産方法、抗体およびスクリーニング方法
Cell cycle-regulating proteins
造腫瘍能があり浸潤・転移能がない癌細胞、その作成方法およびそれを用いた転移関連遺伝子のスクリーニング法

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Books (19)：

Aurora shed a light over cell division mechanisms. In: Dynamical Genetics
Research Signpost 2005
Aurora shed a light over cell division mechanisms. In: Dynamical Genetics
Research Signpost 2005
オーロラを観察すれば癌がわかる
「ゲノム革命」勉誠出版 2004
肝転移-メカニズムと臨床-
医学書院 2000
新臨床医のための分子医学シリーズ -癌転移の分子医学-
羊土社 1996

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Lectures and oral presentations (33)：

Survivin, an inhibitor of anoikis, induces activation of nuclear factor (NF)-kappaB pathway
(The 72nd Annual Meeting of the Japanese Cancer Association 2013)
PARP6-C, a splice variant of PARP6, is upregulated after X-irradiation, and its forced overexpression prevents apoptosis
(The 72nd Annual Meeting of the Japanese Cancer Association 2013)
Knockdown of NSUN2 induces accumulation of cells with higher ploidy and micronuclei after X-irradiation
(The 72nd Annual Meeting of the Japanese Cancer Association 2013)
Role of caspase-3 cleaved RhoGDIβ in radiation-induced apoptosis of macrophages
(The 72nd Annual Meeting of the Japanese Cancer Association 2013)
生体機能分子探索シーズに基づく応用生命科学研究:染色体パッセンジャー関連新規分子の活用
(県立広島大学生命環境学部(平成24年度重点研究事業)成果発表会 2013)

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Works (2)：

染色体分配の放射線分子生物学:M期分裂装置を介する動物細胞の放射線応答研究日本原子力研究所
2000 -
放射線に対する細胞応答反応の分子機構原子力安全研究協会
1998 - 1999

Education (2)：

- 1989 Osaka University
- 1989 Osaka University Graduate School, Division of Medicine Oncogene Research

Professional career (1)：

医学博士 (大阪大学)

Work history (7)：

1996 - 2007 Hiroshima University Research Institute for Radiation Biology and Medicine
1995 - 1996 金沢大学がん研究所助手
1995 - 1996 Cancer Research Institute, Kanazawa University
1996 - - Research Insitute for Radiation Biology and Medicine, Hiroshima University
1994 - 1995 米国オークリッジ国立研究所生物部 Visiting scientist

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Committee career (2)：

2013/10 - 現在庄原市図書館協議会委員
2013/04 - 現在 NPO法人邦楽広島フォーラム副理事

Awards (2)：

2004 - 平成16年度がん転移学会優秀演題賞
1997 - 放射線影響協会研究奨励賞受賞

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