Rchr
J-GLOBAL ID:200901060451619188   Update date: Oct. 30, 2024

YAMAMURA Hisao

ヤマムラ ヒサオ | YAMAMURA Hisao
Affiliation and department:
Job title: Professor
Homepage URL  (1): http://www.phar.nagoya-cu.ac.jp/hp/ysg/index.html
Research field  (5): Clinical pharmacy ,  Pharmacology ,  Physiology ,  Cardiology ,  Respiratory medicine
Research keywords  (10): Ion Channel ,  Calcium Signal ,  Pulmonary Hypertension ,  イオンチャネル創薬 ,  受容体創薬 ,  血管リモデリング ,  Portal Hypertension ,  高血圧 ,  Vascular Smooth Muscle ,  難病
Research theme for competitive and other funds  (25):
  • 2022 - 2025 Drug discovery targeting ion channels for the treatment of pulmonary hypertension
  • 2022 - 2024 肺動脈性肺高血圧症に対する抗体医薬の探索
  • 2019 - 2023 Physiological role of TRIC-B in heart hunction
  • 2019 - 2023 カルシウム感知受容体による新たな内耳カルシウム調節機構の解明とその応用
  • 2018 - 2023 Pathophysiological functions of ion channels in the chronic inflammatory and fibrotic disorders
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Papers (144):
  • Hiroki Mishima, Shunsuke Ando, Hibiki Kuzuhara, Aya Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura. Melatonin inhibits voltage-gated potassium KV4.2 channels and negatively regulates melatonin secretion in rat pineal glands. American journal of physiology. Cell physiology. 2024. 327. 4. C1023-C1034
  • Aya Yamamura, Moe Fujiwara, Akiko Kawade, Taiki Amano, Alamgir Hossain, Md Junayed Nayeem, Rubii Kondo, Yoshiaki Suzuki, Yasumichi Inoue, Hidetoshi Hayashi, et al. Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension. European journal of pharmacology. 2024. 176564-176564
  • Yuuki Sawai, Yoshiaki Suzuki, Masataka Asagiri, Shigeaki Hida, Rubii Kondo, Gerald W Zamponi, Wayne R Giles, Yuji Imaizumi, Hisao Yamamura. Caveolin-1 forms a complex with P2X7 receptor and tunes P2X7-mediated ATP signaling in mouse bone marrow-derived macrophages. American journal of physiology. Cell physiology. 2024. 326. 1. C125-C142
  • Natsumi Shima, Aya Yamamura, Moe Fujiwara, Taiki Amano, Kazuyuki Matsumoto, Taiga Sekine, Haruka Okano, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura. Up-regulated expression of two-pore domain K+ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension. Frontiers in cardiovascular medicine. 2024. 11. 1343804-1343804
  • Naoya Fukuda, Kohki Toriuchi, Rina Mimoto, Hiromasa Aoki, Hiroki Kakita, Yoshiaki Suzuki, Satoru Takeshita, Tetsuya Tamura, Hisao Yamamura, Yasumichi Inoue, et al. Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4. Neurochemical Research. 2023. 49. 3. 800-813
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MISC (130):
  • 近藤るびい, 川田成紀, 鈴木良明, 山村寿男. CRACチャネル阻害薬はTGF-β1刺激による肝星細胞の活性化を抑制する. 生体機能と創薬シンポジウム要旨集. 2021. 2021
  • Hisao Yamamura. Synchronized simulation with heart. Focus on "Simulation of the effects of moderate stimulation/inhibition of the beta(1)-adrenergic signaling system and its components in mouse ventricular myocytes". AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2016. 310. 11. C841-C843
  • Shanshan Song, Aya Yamamura, Hisao Yamamura, Aleksandra Babicheva, Haiyang Tang, Ramon J. Ayon, Kimberly M. McDermott, Xutong Sun, Stephen M. Black, Ayako Makino, et al. Hot, Heat and Stretch All Contribute to the Enhanced Ca2+ Signaling in Pulmonary Arterial Hypertension. FASEB JOURNAL. 2016. 30
  • Haiyang Tang, Aya Yamamura, Dustin R. Fraidenburg, Shanshan Song, Hisao Yamamura, Jiwang Chen, Yali Gu, Ramon J. Ayon, Stephan M. Black, Joe G. N. Garcia, et al. Calcium-sensing Receptor, Coupled with Transient Receptor Potential Canonical Channels 6, Regulates Cytosolic [Ca2+] in the Development and Progression of Pulmonary Hypertension. FASEB JOURNAL. 2016. 30
  • 古川奈美, 山村寿男, 近藤るびい, 鈴木良明, 今泉祐治. 肝硬変由来門脈圧亢進症モデルマウスの門脈平滑筋におけるTMEM16Aチャネルの発現および機能低下. 日本薬理学会近畿部会プログラム・要旨集. 2016. 130th
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Patents (4):
  • 肺動脈性肺高血圧症等の治療剤及びその利用
  • イオンチャネルに作用する化合物のスクリーニング用材料及びその利用(追加特許出願)
  • イオンチャネルに作用する化合物のスクリーニング用材料及びその利用
  • 骨腫瘍の治療剤及び骨腫瘍等の治療のためのイオンチャネル作用薬の評価方法
Education (3):
  • 1999 - 2002 Nagoya City University Graduate School of Pharmaceutical Sciences
  • 1997 - 1999 Nagoya City University Graduate School of Pharmaceutical Sciences
  • 1993 - 1997 Nagoya City University Faculty of Pharmaceutical Sciences
Professional career (1):
  • Ph.D. (Nagoya City University)
Work history (7):
  • 2018/04 - 現在 Nagoya City University Graduate School of Pharmaceutical Sciences
  • 2012/04 - 2018/03 Nagoya City University Graduate School of Pharmaceutical Sciences, Associate Professor
  • 2009/04 - 2012/03 Nagoya City University Graduate School of Pharmaceutical Sciences, Lecturer
  • 2010/10 - 2011/10 University of illinois at Chicago, Department of Medicine, Visiting Scientist
  • 2007/04 - 2009/03 Nagoya City University Graduate School of Pharmaceutical Sciences
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Committee career (6):
  • American Journal of Physiology Cell Physiology Editorial Board
  • 日本平滑筋学会 評議員、監事
  • 日本薬理学会 学術評議員、代議員
  • Frontiers in Pharmacology Reviewing Editor
  • Frontiers in Physiology Associate Editor
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Awards (3):
  • 2023/03 - 日本薬学会 学術振興賞
  • 2013 - Young Investigator Award in the Japanese Pharmacological Society
  • 2001 - 大幸財団 学芸奨励生
Association Membership(s) (6):
The American Physiological Society ,  The Japan Society of Smooth Muscle Research ,  Japanese Association of Cardiovascular Pharmacology ,  The Physiological Society of Japan ,  The Pharmaceutical Society of Japan ,  The Japanese Pharmacological Society
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