Research field (5):
Clinical pharmacy
, Pharmacology
, Physiology
, Cardiology
, Respiratory medicine
Research keywords (10):
Ion Channel
, Calcium Signal
, Pulmonary Hypertension
, イオンチャネル創薬
, 受容体創薬
, 血管リモデリング
, Portal Hypertension
, 高血圧
, Vascular Smooth Muscle
, 難病
Research theme for competitive and other funds (25):
2022 - 2025 Drug discovery targeting ion channels for the treatment of pulmonary hypertension
2022 - 2024 肺動脈性肺高血圧症に対する抗体医薬の探索
2019 - 2023 Physiological role of TRIC-B in heart hunction
2019 - 2023 カルシウム感知受容体による新たな内耳カルシウム調節機構の解明とその応用
2018 - 2023 Pathophysiological functions of ion channels in the chronic inflammatory and fibrotic disorders
2019 - 2022 肺高血圧症に関与するカルシウム関連イオンチャネルの機能解析と創薬
2015 - 2019 Conditional TRIC-B knockout mice production and functional analysis
2017 - 2019 ミトフュージンを中核とした細胞内酸素およびカルシウム制御機構の解明
2016 - 2019 門脈圧亢進症に関与するTMEM16チャネルの発現および機能解析
2016 - 2018 Generation of a novel cell-based assay system for screening agents specific to two-pore domain K+ channels
2014 - 2018 Molecular pharmacological analyses of calcium-activated ion channels as novel drug targets
2014 - 2016 Developement of a novel screening system for drugs acting on ion channels based on measurement of cell death
2013 - 2016 カルシウム活性化クロライドチャネルTMEM16の新規修飾サブユニットの同定
2011 - 2014 Positive feedback mechanism for the regulation of intracellular Ca2+ concentration and related ion channels as novel drug targets
2011 - 2013 血管平滑筋のカルシウムマイクロドメインを安定化させる新規足場構造の同定
2011 - 2012 Development of recombinant cell lines dying upon single action potentialoccurrence and the new screening system for compounds acting on ion channels
2009 - 2011 血管平滑筋カルシウムマイクロドメインを構成する新規分子群の一分子可視化解析
2008 - 2010 Novel molecular functions of calcium-activated potassium channel as a target of drug development
2005 - 2007 Analyses of calcium-activated potassium channels as novel targets for new drug therapy
2005 - 2006 生細胞内オルガネラ膜上タンパク質の一分子可視化技術の開拓
2002 - 2005 デジェネリンファミリーに属する新規遺伝子のクローニングおよび機能解析
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Papers (144):
Hiroki Mishima, Shunsuke Ando, Hibiki Kuzuhara, Aya Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Hisao Yamamura. Melatonin inhibits voltage-gated potassium KV4.2 channels and negatively regulates melatonin secretion in rat pineal glands. American journal of physiology. Cell physiology. 2024. 327. 4. C1023-C1034
Aya Yamamura, Moe Fujiwara, Akiko Kawade, Taiki Amano, Alamgir Hossain, Md Junayed Nayeem, Rubii Kondo, Yoshiaki Suzuki, Yasumichi Inoue, Hidetoshi Hayashi, et al. Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension. European journal of pharmacology. 2024. 176564-176564
Yuuki Sawai, Yoshiaki Suzuki, Masataka Asagiri, Shigeaki Hida, Rubii Kondo, Gerald W Zamponi, Wayne R Giles, Yuji Imaizumi, Hisao Yamamura. Caveolin-1 forms a complex with P2X7 receptor and tunes P2X7-mediated ATP signaling in mouse bone marrow-derived macrophages. American journal of physiology. Cell physiology. 2024. 326. 1. C125-C142
Natsumi Shima, Aya Yamamura, Moe Fujiwara, Taiki Amano, Kazuyuki Matsumoto, Taiga Sekine, Haruka Okano, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura. Up-regulated expression of two-pore domain K+ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension. Frontiers in cardiovascular medicine. 2024. 11. 1343804-1343804
Hisao Yamamura. Synchronized simulation with heart. Focus on "Simulation of the effects of moderate stimulation/inhibition of the beta(1)-adrenergic signaling system and its components in mouse ventricular myocytes". AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2016. 310. 11. C841-C843
Shanshan Song, Aya Yamamura, Hisao Yamamura, Aleksandra Babicheva, Haiyang Tang, Ramon J. Ayon, Kimberly M. McDermott, Xutong Sun, Stephen M. Black, Ayako Makino, et al. Hot, Heat and Stretch All Contribute to the Enhanced Ca2+ Signaling in Pulmonary Arterial Hypertension. FASEB JOURNAL. 2016. 30
Haiyang Tang, Aya Yamamura, Dustin R. Fraidenburg, Shanshan Song, Hisao Yamamura, Jiwang Chen, Yali Gu, Ramon J. Ayon, Stephan M. Black, Joe G. N. Garcia, et al. Calcium-sensing Receptor, Coupled with Transient Receptor Potential Canonical Channels 6, Regulates Cytosolic [Ca2+] in the Development and Progression of Pulmonary Hypertension. FASEB JOURNAL. 2016. 30
1999 - 2002 Nagoya City University Graduate School of Pharmaceutical Sciences
1997 - 1999 Nagoya City University Graduate School of Pharmaceutical Sciences
1993 - 1997 Nagoya City University Faculty of Pharmaceutical Sciences
Professional career (1):
Ph.D. (Nagoya City University)
Work history (7):
2018/04 - 現在 Nagoya City University Graduate School of Pharmaceutical Sciences
2012/04 - 2018/03 Nagoya City University Graduate School of Pharmaceutical Sciences, Associate Professor
2009/04 - 2012/03 Nagoya City University Graduate School of Pharmaceutical Sciences, Lecturer
2010/10 - 2011/10 University of illinois at Chicago, Department of Medicine, Visiting Scientist
2007/04 - 2009/03 Nagoya City University Graduate School of Pharmaceutical Sciences
2005/04 - 2007/03 Nagoya City University Graduate School of Pharmaceutical Sciences, Assistant Professor
2002/04 - 2005/03 Postdoctal fellow of the Japan Society for the Promotion of Science
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Committee career (6):
American Journal of Physiology Cell Physiology Editorial Board
日本平滑筋学会 評議員、監事
日本薬理学会 学術評議員、代議員
Frontiers in Pharmacology Reviewing Editor
Frontiers in Physiology Associate Editor
Journal of Pharmacological Sciences編集委員
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Awards (3):
2023/03 - 日本薬学会 学術振興賞
2013 - Young Investigator Award in the Japanese Pharmacological Society
2001 - 大幸財団 学芸奨励生
Association Membership(s) (6):
The American Physiological Society
, The Japan Society of Smooth Muscle Research
, Japanese Association of Cardiovascular Pharmacology
, The Physiological Society of Japan
, The Pharmaceutical Society of Japan
, The Japanese Pharmacological Society