Azuma Haruhito

アズマハルヒト | Azuma Haruhito

Affiliation and department：
Other affiliations (1)：

Osaka Medical and Pharmaceutical University

Research field (1)： Urology

Research theme for competitive and other funds (29)：

2021 - 2026 Therapeutic effect of boron neutron supplementation therapy with PDL1 antibody for advanced bladder cancer (including metastasis)
2021 - 2026 Development of synthetic lethal approach for chemo-radiation resistant tumor
2020 - 2024 Development of a method for enhancing the antitumor effect and reducing the side effects in therapy for Bladder cancer with Mycobacterium Bovis (BCG) by Macrophage adsorbent
2020 - 2024 変異SETD2の機能喪失メカニズムの解析と腎癌に対する免疫療法への応用
2019 - 2024 Studies on a novel immunotherapy for bladder cancer by NAD+

2018 - 2022 A Developing Diagnostic Method of Invasion Depth about Bladder Cancer, using a new Multi-Parametric MRI and applying it to a Therapeutic Strategy

2016 - 2021 癌細胞選択的破壊「硼素膀胱局所動注+中性子照射」による新規膀胱温存療法

2017 - 2020 Investigation of new therapy for prevention of recurrence of the bladder cancer by macrophage control.

2016 - 2020 Therapy for bladder cancer by means of a novel delivery carrier for miR-145

2014 - 2017 Development of allo-activated macrophage suppression method aiming at efficiency of Intravenous Immunoglobulin therapy

2013 - 2017 Role of glycosylation on the functions of cardiac calcium regulating proteins and ion channels

2014 - 2016 The permanent survival of allografts by tolerance induction mediated by the combined therapy of adoptive transfer of Treg cells and the MF-1-gene transfection

2014 - 2015 Tregバンク(CD28SA+肝細胞共培養)免疫寛容+MF1導入:移植腎永久生着

2012 - 2013 革新的膀胱温存療法:「硼素膀胱局所動注+中性子照射」による癌細胞選択的破壊

2009 - 2013 Tregバンク(CD28SA+肝細胞共培養)免疫寛容+MF1導入:移植腎永久生着

2010 - 2011 癌細胞選択的破壊による革新的浸潤癌膀胱温存治療「硼素膀胱局所動注中性子捕捉療法」

2008 - 2009 レンチウイルスを用いたメトロンファクタ-1 遺伝子導入による腎移植慢性拒絶の治療効果

2008 - 2009 3種抗体、および、レンチウイルスを用いた移植腎生着延長の試み

2007 - 2009 Induction of kidney graft tplerance using donor-specofoc regulatory T cells

2006 - 2009 Identification of responsible gene of bone metastasis in prostate cancer and its treatment using a recombinant HSV

2006 - 2008 新免疫寛容導入法の確立とメトロン遺伝子ゲノム内導入による移植腎永久正着の試み

2003 - 2005 造影剤+超音波によるNFBデコイ-HGF遺伝子同時導入:移植腎長期生着の試み

1995 - 2004 癌転移機序の解明とその治療

1992 - 2004 腎臓移植における免疫学的寛容の確立と長期生着

1999 - 2000 分子生物学的手法を用いた腎移植慢性拒絶反応に対する治療の試み

1999 - 2000 遺伝子導入(HGF,変異TGFβレセプター)による腎移植慢性拒絶反応の治療の試み

1997 - 1998 腎移植慢性拒絶反応の発症メカニズムとその治療:HGFは初の治療薬?

臓器移植における免疫学的寛容の獲得

癌転移抑制

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Papers (307)：

Taizo Uchimoto, Shuya Tsuchida, Kazumasa Komura, Wataru Fukuokaya, Takahiro Adachi, Yosuke Hirasawa, Takeshi Hashimoto, Atsuhiko Yoshizawa, Masanobu Saruta, Mamoru Hashimoto, et al. Durable Response to Enfortumab Vedotin Compared to Re-challenging Chemotherapy in Metastatic Urothelial Carcinoma After Checkpoint Inhibitors. Targeted oncology. 2024
Hajime Hirano, Yuya Fujiwara, Tomota Okabe, Keita Nakamori, Koichiro Minami, Hirofumi Uehara, Hayahito Nomi, Kazumasa Komura, Teruo Inamoto, Haruhito Azuma. Importance of Management of Lifestyle-Related Diseases After Kidney Donation to Living Donors. Transplantation proceedings. 2024
Ko Nakamura, Takaya Ohno, Teruo Inamoto, Tomoaki Takai, Taizo Uchimoto, Tatsuo Fukushima, Kazuki Nishimura, Yusuke Yano, Kyosuke Nishio, Shoko Kinoshita, et al. Pattern of expression of microRNA in patients with radiation induced bladder injury. Oncology. 2023
Wataru Fukuokaya, Yuhei Koike, Yuji Yata, Kazumasa Komura, Taizo Uchimoto, Takuya Tsujino, Masanobu Saruta, Kiyoshi Takahara, Kazutoshi Fujita, Takafumi Minami, et al. Real world evidence of enfortumab vedotin in patients with advanced urothelial cancer: A multicenter observational study. International journal of urology : official journal of the Japanese Urological Association. 2023
Shota Fujii, Mitsuaki Ishida, Kazumasa Komura, Kazuki Nishimura, Takuya Tsujino, Tomohito Saito, Yohei Taniguchi, Tomohiro Murakawa, Haruhito Azuma, Yoshinobu Hirose. Expression of Preferentially Expressed Antigen in Melanoma, a Cancer/Testis Antigen, in Carcinoma In Situ of the Urinary Tract. Diagnostics (Basel, Switzerland). 2023. 13. 24

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MISC (987)：

Kazuki Nishimura, Kazumasa Komura, Kensuke Hirosuna, Mitsuaki Ishida, Teruo Inamoto, Haruhito Azuma, Akihide Yoshimi. A comprehensive multi-omics analysis exploring the correlation between NECTIN4 and tumor microenvironment profiles in bladder cancer. JCO Global Oncology. 2023. 2023. 9. 74-74
福島龍生, 前之園良一, 能見勇人, 藤原裕也, 上原博史, 平野一, 稲元輝生, 東治人, 松村英樹, 芦田明, et al. LMX1B遺伝子変異を認めないNPLRDに対して生体腎移植を施行した1例. 泌尿器科紀要. 2023. 69. 12
藤井裕子, 松村英樹, 田中智子, 山崎哲司, 中倉兵庫, 白數明彦, 能見勇人, 平野一, 東治人, 芦田明. 先天性難病による精神発達遅滞と自閉スペクトラム症の併存症がある成人例における腎代替療法の選択. 日本小児腎不全学会学術集会プログラム・抄録集. 2022. 43rd
柳原一隆, 内本泰三, 福岡屋航, 上原博史, 小村和正, 平野一, 能見勇人, 稲元輝生, 木村高弘, 穎川晋, et al. Pembrolizumab投与した転移性尿路上皮癌における6week後Objective response rate(ORR)とNLR変化の検討. 日本泌尿器科学会中部総会プログラム・抄録集. 2021. 71st
福島龍生, 内本泰三, 福岡屋航, 上原博史, 小村和正, 平野一, 能見勇人, 稲元輝生, 木村高弘, 穎川晋, et al. 転移性去勢抵抗性前立腺癌(mCRPC)におけるOS層別化モデルと外部コホートによる有用性の検証. 日本泌尿器科学会中部総会プログラム・抄録集. 2021. 71st

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Education (1)：

1951 - 現在 Osaka Medical College Faculty of Medicine Division of Medicine

Professional career (1)：

医学博士

Awards (3)：

2007/04 - Awards of annual meeting of Japanese urologocal assocoation
2005/04 - Award of Japanese urological association Transfection of NFkB-decoy oligodeoxynucleotides using efficient ultrasound-mediated gene transfer into donor kidneys prolonged survival of rat renal allografts
2004/04 - Awards of annual meeting of Japanese urologocal assocoation

Association Membership(s) (22)：

日本泌尿器科分子生物研究会 , 11 , 日本移植臨床研究会 , 10 , 日本腎移植病理学会 , 9 , 日本臓器保存生物医学会 , 8 , 国際移植学会 , 7 , 日本透析医学会 , 6 , 日本腎臓学会 , 5 , 日本移植学会 , 4 , 日本癌転移学会 , 3 , 日本癌治療学会 , 2 , 日本泌尿器科学会 , 1

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