Yano Hajime

ヤノハジメ | Yano Hajime

Affiliation and department：
Job title： Associate Professor

Research field (1)： Cell biology

Research keywords (8)：メカノトランスダクション , 癌浸潤 , 細胞運動 , 細胞生理学 , mechanotrunsduction , Cancer invasion , Cell migration , Cell physiology

Research theme for competitive and other funds (23)：

2021 - 2024 Development of a novel diagnostic and therapeutic principle by targeting LOXL2 localized on the extracellular vesicle in the head and neck squamous carcinoma patient serum.
2018 - 2021 Development of a multidisciplinary anti-metastasis treatment against lymph node metastasis of head and neck squamous cell carcinomas
2016 - 2019 The effect of LOXL2 in head and neck squamous cell carcinoma lymph node metastasis
2015 - 2018 Analyses of the activation mechanism of latent form TGFbeta in the lymph node metastasis of head and neck squamous cell carcinoma
2011 - 2013 Suppressive control of glioma invasions via inhibition of sodium ion/proton exchanger 1

2011 - 2012 Determination of cell type(s) that should be transplanted into lesion core of the brain for better outcome

2010 - 2012 Multipotential stem cell-like nature of bone marrow-derived macrophages accumulated in lesion core of acute and severe brain injuries.

2009 - 2010 神経膠腫細胞浸潤におけるArf6依存性および非依存性の意義

2008 - 2010 Analyses of the fine-tuning mechanism of Arf6 activity on reorganization of epithelial organ

2007 - 2010 メカノトランスダクションによる細胞核機能制御の分子機構の解析

2007 - 2010 Analyses of the molecular mechanisms controling cell nucleus function mediated by mechanotrunsduction.

2007 - 2009 神経膠腫細胞の浸潤性制御機構の解析

2007 - 2009 Analyses of Molecular Mechanisms of Glioma cell invasion

2003 - 2004 チロシンリン酸化シグナルを介する微小管構築制御機構の解析

2002 - 2003 Cell motility and the backward bulk flow of the plasma membrane components

2001 - 2002 インテグリン裏打ち蛋白質群による上皮細胞の細胞運動性制御機構の解析

2000 - 2001 Role of paxillin-associatcd ARFGAPs in cell migration.

1999 - 2001 インテグリンを介する細胞接着シグナル制御と癌化細胞の生存性・侵潤能の解析

2000 - 2000 インテグリンを介する細胞接着シグナル制御と癌化細胞の生存性・浸潤能の解析

1999 - 1999 上皮間充織形質転換におけるインテグリン活性化と発がん機構の分子解析

1998 - 1999 Role of paxillin isoforms and their tyrosine phosphorylation in cell migration.

1998 - 1998 単球・マクロファージ細胞の接着及び貧食過程におけるパキシリンの機能解析

1996 - 1997 Molecular Mechanism of activation of glucose transporters by noradrenaline in primary cultures of brown adipocytes and L6 myocytes.

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Papers (112)：

Yoshihiro Ohtsuka, Satoshi Suehiro, Akihiro Inoue, Takanori Ohnishi, Masahiro Nishikawa, Daisuke Yamashita, Hajime Yano, Mohammed E Choudhury, Saya Ozaki, Oltea Sampetrean, et al. Berberine as a potential enhancer for 5-ALA-mediated fluorescence in glioblastoma: increasing detectability of infiltrating glioma stem cells to optimize 5-ALA-guided surgery. Journal of neurosurgery. 2024. 1-11
Haruna Takeda, Yoshihiro Nakajima, Teruaki Yamaguchi, Itaru Watanabe, Shoko Miyoshi, Kodai Nagashio, Hiroki Sekine, Hozumi Motohashi, Hajime Yano, Junya Tanaka. The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2. Journal of biochemistry. 2023. 174. 2. 131-142
Yuki Nishikawa, Mohammed E Choudhury, Kanta Mikami, Matsuura Taisei, Madoka Kubo, Masahiro Nagai, Satoru Yamagishi, Tomomi Doi, Manami Hisai, Haruto Yamamoto, et al. Anti-inflammatory effects of dopamine on microglia and a D1 receptor agonist ameliorates neuroinflammation of the brain in a rat delirium model. Neurochemistry international. 2023. 105479-105479
Haruna Takeda, Yumiko Yoshimura, Masahiro Takagi, Arisa Sato, Nanako Kihara, Mohammed E. Choudhury, Hajime Yano, Junya Tanaka. Bromovalerylurea modulates GABAA receptor-mediated inhibitory neurotransmission while inducing sleep. Biochemical and Biophysical Research Communications. 2023. 638. 176-183
Mohammed E Choudhury, Saya Ozaki, Noriyuki Miyaue, Taisei Matsuura, Kanta Mikami, Afsana Islam, Madoka Kubo, Rina Ando, Hajime Yano, Takeharu Kunieda, et al. Chloride Intracellular Channel Protein 2 Promotes Microglial Invasion: A Link to Microgliosis in the Parkinson's Disease Brain. Brain sciences. 2022. 13. 1

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MISC (69)：

武田遥奈, 吉村由美子, 中島芳浩, 山口輝昌, 佐藤安理沙, 木原奈那子, ME Choudhury, 矢野元, 田中潤也. ブロモバレリル尿素の睡眠作用・抗炎症作用の解析. 日本生理学雑誌(Web). 2021. 83. 1
田中潤也, 宇都宮諒, E.M.・チョードリ, 矢野元, 城賀本敏宏. 新たな注意欠陥多動障害モデル動物リスター・フーディッド・ラットLHR. 日本病態生理学会雑誌. 2019. 28. 2. 42-42
早瀬絵理香, 馬越陽大, 尾崎沙耶, 住田悠太郎, 上野義智, 高田泰次, 國枝武治, 矢野元, 田中潤也. ラットがん遠隔転移モデルの作成から始まった、Chloride intracellular channel protein 2(CLIC2)による転移抑制効果の発見. 日本生理学雑誌. 2019. 81. 2. 32-32
宇都宮諒, 城賀本敏宏, 石井榮一, E.M.・チョードリ, 宮西和也, 矢野元, 田中潤也. 新たな注意欠陥・多動性障害(ADHD)モデルとしてのLister hooded rat. 日本生理学雑誌. 2019. 81. 2. 33-33
武田遥奈, 瀬尾尚登, 藤田滉大, 佐藤安理沙, 木原奈那子, CHOUDHURY ME, 矢野元, 田中潤也. 催眠鎮静薬ブロモバレリル尿素の睡眠作用・抗炎症作用の解析. 日本生理学雑誌(Web). 2019. 81. 2

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Books (4)：

培養細胞実験ハンドブック
羊土社 2009
Handbook for culture cell experiments.
YODOSYA 2009
メンブレントラフィックの奔流
共立出版 2008
(No english title)
Kyorutsu Syuppan 2008

Education (6)：

- 1995 Osaka University
- 1995 Osaka University Graduate School, Division of Medicine Physiology
- 1991 Osaka University
- 1991 Osaka University Medical Science
- 1989 Osaka University Faculty of Human Sciences

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Professional career (3)：

Ph.D (Osaka University)
Master Degree of Medical Science (Osaka University)
Bachelor's Degree of Social Science (Osaka University)

Committee career (1)：

2008 - 2008 日本生理学会中四国地方会事務局長

Association Membership(s) (12)：

日本病態生理学会 , 日本生理学会 , 日本癌学会 , 日本細胞生物学会 , 日本分子生物学会 , 日本生化学会 , Japanese Society of Pathophysiology , Physiological Society of Japan , Japanese Cancer Association , Japan Society for Cell Biology , The Molecular Biology Society of Japan , The Japanese Biochemical Society.

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