Rchr
J-GLOBAL ID：200901060739303282
Update date: Dec. 31, 2024
HIROSHI SEKIGUCHI
セキグチ ヒロシ | HIROSHI SEKIGUCHI
Affiliation and department：
Job title：
主幹研究員
Research field (4)：
Quantum beam science
, Biophysics
, Nanobioscience
, Nanomaterials
Research keywords (7)：
single molecule experiment
, atomic force microscopy
, ナノ計測
, 生物科学研究法
, 生物物理学
, Research methods in biological sciences
, Biophysics
Research theme for competitive and other funds (21)：
- 2023 - 2026 X線を用いた高速1分子運動解析による膜タンパク質オペランド計測の実現
- 2022 - 2025 Study of Serious Problems of Conventional Methods in the Evaluation of Ultimate Mechanical Property of Polymer Crystals as a Guiding Principle for the Development of Ultra-Strong Polymers
- 2021 - 2024 クチナーゼCut190のCa2+結合に伴う動的構造変化とPET分解分子機構の解明
- 2020 - 2023 Determination of single hemoglobin dynamics with x-rays
- 2020 - 2021 生きた細胞におけるチャネルタンパク質・X線1分子動態アッセイシステムの開発
- 2020 - 2021 生細胞・膜タンパク質の分子内動態を可視化する 低侵襲・回折X線ブリンキング法の開発
- 2014 - 2019 3D Active Site Science in Biology
- 2017 - 2018 Development of diffracted X-ray photon tracking for single molecule intra- dynamics
- 2016 - 2017 高次元フォトン情報駆動型1分子追跡法の開発
- 2014 - 2016 Quantification of protein conformational entropy on helix-bundle formation
- 2015 - 2016 マイクロ秒X線1分子追跡法によるイオンチャネル・分子内協同性の可視化
- 2012 - 2015 Studies on the subunit cooperative mechanism in the reaction cycle of group 2 chaperonin
- 2012 - 2014 Multiscale motion analysis of membrane proteins at neuromuscular junction
- 2011 - 2013 高速1分子動態計測による膜タンパク質機能発現機構の解明
- 2012 - 2013 タンパク質フォールディング・実時間計測に向けたフロー型X線1分子追跡法の開発
- 2010 - 2012 Development of Compact Diffracted X-ray Tracking Instrumentation
- 2007 - 2011 Single Molecule Mechanics and Computer Modeling of Cascading System of Biological Information Transfer
- 2007 - 2008 Quantification of the immobilized bio-molecules on the tip of AFM cantilever
- 2007 - 2008 Compression of Protein Molecules
- 2005 - 2006 AFM力学測定のための生体分子の基板への固定法開発
- 2003 - 2006 Time lapse nano-analysis of single cell components : Development of Harvesting, Identification and Injection Methods of Functional Molecules
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Papers (108)：
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Ayaka Takazawa, Takeshi Yamanobe, Hiroki Uehara, Takuya Ohnishi, Yasutake Wakabayashi, Kouki Aoyama, Hiroshi Sekiguchi, Masaki Kakiage. Oriented crystalline structure in melt-drawn ultrahigh-molecular-weight polyethylene induced by entanglement networks. Polymer. 2024
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Mutsumi Yoshida, Yuya Hanazono, Nobutaka Numoto, Satoshi Nagao, Saaya Yabuno, Yumi Kitagawa, Hiroshi Sekiguchi, Nobutoshi Ito, Takachika Azuma, Masayuki Oda. Affinity-matured antibody with a disulfide bond in H-CDR3 loop. Archives of Biochemistry and Biophysics. 2024
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Shoko Kojima, Lidong Zhang, Chandan Kumar, Hayato Sumi, Norobu Ohta, Hiroshi Sekiguchi, Kentaro Tsuzuki, Shunta Harada, Toru Ujihara, Katsuo Tsukamoto, et al. The effects of polyethylene glycol on the nucleation and growth of DNA-functionalized gold nanoparticles crystals. Journal of Crystal Growth. 2024
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Daisuke Sasaki, Tatsuya Arai, Yue Yang, Masahiro Kuramochi, Wakako Furuyama, Asuka Nanbo, Hiroshi Sekiguchi, Nobuhiro Morone, Kazuhiro Mio, Yuji C. Sasaki. Micro-second time-resolved X-ray single-molecule internal motions of SARS-CoV-2 spike variants. Biochemistry and Biophysics Reports. 2024. 38. 101712-101712
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Yue Yang, Tatsuya Arai, Daisuke Sasaki, Masahiro Kuramochi, Hidetoshi Inagaki, Sumiko Ohashi, Hiroshi Sekiguchi, Kazuhiro Mio, Tai Kubo, Yuji C. Sasaki. Real-time tilting and twisting motions of ligand-bound states of α7 nicotinic acetylcholine receptor. European Biophysics Journal. 2024. 53. 1-2. 15-25
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MISC (163)：
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谷中慶三郎, 大久保達成, 大久保達成, 新井達也, 野澤俊介, 関口博史, 古山若呼, 南保明日香, 三尾和弘, 三尾和弘, et al. Molecular dynamics of cell membrane in Ebola virus proliferation using Diffracted X-ray Blinking. 量子ビームサイエンスフェスタ(Web). 2023. 2022
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宮部俊宏, 小園裕子, 笠寺浩介, 松宮陽, 関口博史, 沖本憲明, 泰地真久人, 佐々木裕次, 小園晴生. Dynamical Analysis of Peptide Exchange Mechanism of HLA-DM by Diffracted X-ray Tracking Method. SPring-8/SACLA利用研究成果集(Web). 2021. 9. 1
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Masaki Ishihara, Shoko Fujimura, Kohei Ichiyanagi, Shunsuke Nozawa, Shinichi Adachi, Ryo Fukaya, Masahiro Kuramochi, Hiroshi Sekiguchi, Kazuhiro Mio, Yuji C. Sasaki. Dynamic Internal Motion of GPCR on Live Cells. BIOPHYSICAL JOURNAL. 2020. 118. 3. 56A-56A
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J-W. Chang, Y. S. Baek, K. Mio, M. Mio, H. Sekiguchi, Y. C. Sasaki. X-ray single molecule dynamics of interleukins bonded receptors on live NK cells membranes. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S374-S374
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Y. C. Sasaki, K. Ikezaki, K. Mio, H. Sekiguchi. New X-ray single molecular observations from super-Poisson distribution using laboratory X-rays. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S192-S192
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Patents (1)：
Books (7)：
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3D Local Structure and Functionality Design of Materials
Maruzen Publishing 2018 ISBN:9789813273665
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SPring-8 Research Frontiers 2014,
2015
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Advances in Chemical Physics, Volume 146, Single Molecule Biophysics: Experiments and Theories
WILEY 2011 ISBN:9781118057803
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走査プローブ顕微鏡 (実験物理科学シリーズ6)
共立出版 2009 ISBN:9784320033818
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Applied Scanning Probe Methods IX : Characterization
Springer 2008 ISBN:9783540740827
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Lectures and oral presentations (61)：
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放射光X線を利用したタンパク質・ダイナミクス研究
(学変Bメタアグリゲート 外部セミナー 2024)
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放射光X線を利用したソフトマター動的構造評価の現状と未来
(第43回無機高分子討論会 2024)
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Dynamics measurement of bio-soft materials using synchrotron radiation X-rays
(9th International Symposium of Quantum Beam Science 2024)
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放射光X線を利用したバイオ・ソフトマテリアルのダイナミクス計測
(バイオインタラクション研究会 第22回ワークショップ 2023)
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Allosteric transition dynamics in hemoglobin Reconsidered by Diffracted X-ray Tracking
(The 60th Annual Meeting of the Biophysical Society of Japan 2022)
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Education (4)：
- 2001 - 2004 Tokyo Institute of Technology Graduate School of Bioscience & Biotechnology Department of Life Sciences
- 1999 - 2001 Tokyo Institute of Technology Graduate School of Bioscience & Biotechnology Department of Life Sciences
- 1995 - 1999 Tokyo Institute of Technology Graduate School of Bioscience & Biotechnology
- 1991 - 1994 千葉県立木更津高等学校 普通科
Professional career (1)：
- Doctor of Science (Tokyo Institute of Technology)
Work history (17)：
- 2023/10 - 現在 RIKEN SPring-8 Center, Life Science Research Infrastructure Group visiting researcher
- 2022/04 - 現在 Japan Synchrotron Radiation Research Institute Research Project Division Researcher
- 2021/04 - 現在 Japan Synchrotron Radiation Research Institute
- 2019/04 - 現在 Japan Synchrotron Radiation Research Institute
- 2019/04 - 2023/12 The University of Tokyo Graduate School of Frontier Sciences
- 2018/04 - 2021/03 Japan Synchrotron Radiation Research Institute
- 2017/04 - 2019/03 Japan Synchrotron Radiation Research Institute Research & Utilization Division Seniror Scientist
- 2017/09 - 2018/03 Tokyo Institute of Technology School of Life Science and Technology part-time lecturer
- 2015/04 - 2018/03 Japan Synchrotron Radiation Research Institute
- 2013/04 - 2017/08 The University of Tokyo Graduate School of Frontier Sciences part-time lecturer
- 2015/04 - 2017/03 Japan Synchrotron Radiation Research Institute Research & Utilization Division Associate Senior Scientist
- 2012/04 - 2015/03 Japan Synchrotron Radiation Research Institute Research & Utilization Division Research Scientist
- 2009/08 - 2012/03 The University of Tokyo Project Research Associate
- 2007/04 - 2009/07 Tokyo Institute of Technology Assistant Professor
- 2004/12 - 2007/03 Tokyo Institute of Technology Assistant Professor
- 2004/04 - 2004/11 National Food Research Institute of Japan Postdoctoral Fellow
- 2001/10 - 2004/03 RIKEN Junior Research Associate
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Committee career (7)：
- 2022/08 - 現在 Scientific Reports Editorial Board Member
- 2017/10 - 2019/09 The Japanese Society for Synchrotron Radiation Research Editorial Board Member
- 2012/04 - 2018/03 Foundation Advanced Technology Institute Bio Single-Molecule Committee
- 2016/05 - 2018/01 The Japanese Society for Synchrotron Radiation Research Program Committee
- 2015/04 - 2016/03 日本生物物理学会 分野別専門員 (放射光)
- 2008/04 - 2012/03 Foundation Advanced Technology Institute Bio-SPM Workshop Committee
- 2008/04 - 2010/03 Surface Science Society of Japan Annual Meeting Organizing Committee
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Awards (4)：
- 2022/06 - Shape Memory and Superelasticity 2021 Best Paper Award Dynamics of Phase Fronts During High-Driving-Force Transformation of Shape Memory Alloy Wires
- 2012/08 - International Workshop on 3D atomic imaging at nano-scale active sites Best Poster Awards Cooperativity analysis of multi-subunit proteins by 3D X-ray single molecule tracking
- 2007 - Surface Science Society of Japan Young-Researcher Lecture Award
- 2007 - Surface Science Society of Japan Young Researcher Award
Association Membership(s) (4)：
THE JAPANESE SOCIETY FOR SYNCHROTRON RADIATION RESEARCH
, Protein Science Society of Japan
, Biophysical Society of Japan
, Biophysical society
