Rchr

J-GLOBAL ID：200901060764920857 Update date: Jan. 31, 2024

Matsuura Hiroshi

マツウラヒロシ | Matsuura Hiroshi

Affiliation and department：
Job title： Vice President
Homepage URL (1)： http://www.shiga-med.ac.jp/~hqphysi2/

Research field (2)： Clinical pharmacy , Physiology

Research keywords (14)：心筋細胞 , 洞房結節 , 房室結節 , 心臓自動能 , イオンチャネル , 遅延整流性カリウムチャネル , TRPCチャネル , 不整脈 , 撃発活動 , 虚血再灌流傷害 , 活性酸素 , カルシウム過負荷 , プレコンディショニング , ポストコンディショニング

Research theme for competitive and other funds (40)：

2020 - 2023 遺伝性不整脈を呈する変異体Nav1.5チャネルに対する揮発性麻酔薬の修飾作用
2020 - 2023 心臓チャネル病における麻酔薬の心臓作用の包括的解析
2017 - 2023 病態心における吸入麻酔薬の心筋保護作用の分子基盤と新規心筋保護法への発展
2017 - 2021 Potential link between Ca2+-activated cation TRPM4 channels and Ist in cardiac pacemaker cells
2017 - 2020 The risk stratification of drug-induced long QT syndrome upon the underlying genetics

2017 - 2020 Elucidation of mechanisms of myocardial ischemia/reperfusion injury mediated through transient receptor potential canonical (TRPC) channels, and establishment of new therapeutics for its treatment.

2015 - 2018 Effects of Anesthetics on TRPC channel mediated myocardial protection

2015 - 2018 Novel Non-invasive risk stratification of sudden cardiac death in patients with inherited arrhythmias

2014 - 2018 Development of a new therapeutic strategy for preventing the cardiac ischemia/reperfusion injury based on the mechanisms underlying cardioprotective effects of volatile anesthetics

2014 - 2018 Involvements of Cav1.3 in the generation of a sustained inward Na+ current in sinoatrial node cells

2014 - 2018 Molecular identification of the ATP-release Maxi-Cl channel and its roles in ischemia-reperfusion cardiac injury

2013 - 2017 Regulation of cell cycling and functional characterization of atypical-shaped cardiomyocytes (ACMs)

2013 - 2016 Involvement of store-operated calcium entry in ischemia/reperfusion injury in the heart

2012 - 2015 Genetic-based risk of sudden arrhythmic death in the Brugada syndrome

2012 - 2014 The molecular basis underlying cardioprotective action of volatile anesthetics on ischemia/reperfusion injury

2011 - 2013 Investigation on possible link between Ist and CaV1.3 RNA editing

2010 - 2012 The improved effect of hypothermic cultivation on thefunctional expression of human cardiac Kv1.5 channels

2010 - 2012 Functional role of the transient receptor potential canonical (TRPC) channels in the development of cardiac ischemia/reperfusion injury

2010 - 2012 Characterization of novel resident heart cells identified as atypically-shaped cardiomyocytes(ACMs)

2010 - 2011 The molecular and ionic mechanisms for cardioprotective effects of volatile anesthetics

2009 - 2011 Developmental analyses of the cardiac conduction system and cardiomyocytic functions in the rats with congenital cardiac anomalies

2006 - 2007 P2受容体刺激による前駆脂肪細胞の分化誘導因子に対する感受性増大機構の解明

2005 - 2006 Molecular basis for the regulation of the cardiac delayed rectifier K^+ channel by membrane PIP_2

2004 - 2005 Molecular Medicine of Inherited Arrhythmias : Clinical application of genetic analysis

2003 - 2004 Regulation of the cardiac delayed rectifier K^+ channel by membrane PIP_2 and its physiological significance

2001 - 2002 Regulation of the cardiac delayed rectifier K^+ channel by membrane phosphoinositides

1999 - 2000 Properties and role of the delayed rectifier K^+ current in the pacemaker activity

1997 - 1998 An analysis of the enhancement of delayed rectifier K^+ current by P_2-purinoceptor stimulation

1996 - 1996 P_2-プリン作動性受容体による心筋ムスカリン性Kチャネルの制御機構の解明

1995 - 1995 P_2-プリン作動性受容体による心筋ムスカリン性Kチャネルの抑制性修飾機構の解明

1994 - 1994 P_2-プリン作動性受容体による心筋KおよびCl電流調節の細胞内情報伝達機構の解明

1993 - 1993 心筋細胞のP_2-プリン受容体により活性化される電流系の特性とその生理的意義の解明

1992 - 1992 プリン受容体を介する心筋クロライド電流活性化の細胞内調節機構

1991 - 1992 Properties and regulation of cardiac chloride current

P₂-プリン作動性受容体による心筋細胞膜電流の調節

心臓自動能の発生機転

活性酸素による不整脈誘発のイオン機序

P₂-purinergic regulation of cardiac membrane currents.

Pacemaker mechanisms in the heart

Ionic mechanisms of reactive oxygen intermediates-induced arrhythmias.

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Papers (153)：

Akiko Kojima, Yutaka Fukushima, Hiroshi Matsuura. Prediction of anesthetic torsadogenicity using a human ventricular cell model. Journal of Anesthesia. 2023. 37. 5. 806-810
Chao Dong, Jiawei Li, Weiguang Ding, Rika Ueda, Xiaolu Xie, Jie Wu, Hiroshi Matsuura, Minoru Horie. Open channel block of Kv1.5 channels by HMQ1611. Frontiers in Pharmacology. 2022. 13. 965086
Mariko Omatsu-Kanbe, Ryo Fukunaga, Xinya Mi, Hiroshi Matsuura. Atypically Shaped Cardiomyocytes (ACMs): The Identification, Characterization and New Insights into a Subpopulation of Cardiomyocytes. Biomolecules. 2022. 12. 7. 896-896
Morihiro Shimizu, Xinya Mi, Futoshi Toyoda, Akiko Kojima, Wei-Guang Ding, Yutaka Fukushima, Mariko Omatsu-Kanbe, Hirotoshi Kitagawa, Hiroshi Matsuura. Propofol, an Anesthetic Agent, Inhibits HCN Channels through the Allosteric Modulation of the cAMP-Dependent Gating Mechanism. Biomolecules. 2022. 12. 4. 570-570
Ohno Mikiko, Nishi Kiyoto, Matsuura Hiroshi, Makiyama Takeru, Koujitani Hirohiko, Matsuda Shintaro, Kimura Takeshi, Nishi Eiichiro. Metalloprotease Nardilysin regulates sinus automaticity through transcriptional regulation of ion channels. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 3-O-110

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MISC (51)：

大野美紀子, 松浦博, 牧山武, 糀谷泰彦, 西清人, 松田真太郎, 木村剛, 西英一郎. NRDC regulates sinus automaticity through transcriptional regulation of ionchannels. 日本循環薬理学会口演要旨集. 2021. 31st
Ohno Mikiko, Matsuura Hiroshi, Makiyama Takeru, Kojitani Hirohiko, Nishi Kiyoto, Iwasaki Hirotaka, Matsuda Shintaro, Kimura Takeshi, Nishi Eiichiro. Metalloprotease nardilysin controls heart rate through the transcriptional regulation of ion channels critical for sinus automaticity. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 0. 3-P-332
KOJIMA Akiko, MATSUURA Hiroshi. Ischemia- and reperfusion-induced injury in the heart. The Japanese Journal of Acute Medicine. 2019. 43. 12. 1544-1550
熊谷康佑, 豊田太, 前田勉, 奥村法昭, 谷川仁士, 久保充彦, 彌山峰史, 松浦博, 松末吉隆, 今井晋二. 家兎変形性関節症モデルにおける肉眼的軟骨病変形成以前の容積感受性Clイオンチャネルの役割とその分子実体の検討. 日本整形外科学会雑誌. 2019. 93. 8. S1946-S1946
Ohno Mikiko, Matsuura Hiroshi, Makiyama Takeru, Iwasaki Hirotaka, Matsuda Shintaro, Nishi Eiichiro. Metalloprotease nardilysin controls heart rate through the transcriptional regulation of ion channels critical for sinus automaticity. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2019. 92. 0. 2-P-069

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Books (9)：

Autophagy: Cancer, other pathologies, inflammation. immunity, infection and aging
Elsevier 2015
P2-purinergic stimulation of delayed rectifier K+ current in guinea pig cardiac myocytes. In Potassium Channels in Normal and P
Leuven University Press 1995
Potassium Channels in Normal and Pathological Conditions
Leuven University Press, Leuven, Belgium 1995
活性酸素による細胞内Ca負荷と異常自動能の発現.心筋虚血再灌流傷害
世界保健通信社 1994
Reperfusion arrhythmias: role of oxidant stress
Cambridge University Press 1991

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Education (2)：

1985 - 1988 九州大学大学院医学系研究科外科系
1976 - 1982 Hirosaki University School of Medicine Medicine

Professional career (1)：

医学博士 (九州大学)

Work history (11)：

2020/04 - 現在 Shiga University of Medical Science Director
1998/04 - 2020/03 Shiga University of Medical Science Department of Physiology Professor
1995/10 - 1998/03 Saga Medical School Department of Physiology Associate Professor
1992/04 - 1995/09 Saga Medical School Department of Physiology Lecturer
1991/01 - 1992/03 Saga Medical School Department of Physiology Assisitant Professor

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Committee career (1)：

日本生理学会評議員

Awards (2)：

1993 - 第25回(平成5年度)内藤記念科学振興財団・研究助成
1991 - 第7回日本心電学会木村栄一賞

Association Membership(s) (4)：

日本循環器学会 , 日本不整脈心電学会 , 日本生理学会 , 日本医学教育学会

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