Daisuke Takahashi

タカハシダイスケ | Daisuke Takahashi

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： http://www.applc.keio.ac.jp/~toshima/takahashi.html , https://www.applc.keio.ac.jp/~toshima/takahashi_Eng.pdf

Research field (5)： Structural/physical organic chemistry , Bioorganic chemistry , Chemical biology , Bioorganic chemistry , Structural/physical organic chemistry

Research keywords (5)： Glycosylated Natural Products , Chemical Biology , Glycosylation Reaction , Synthetic Organic Chemistry , Carbohydrate Chemistry

Research theme for competitive and other funds (8)：

2022 - 2028 Establishment of platforms for drug discovery and development of novel drugs with broad-spectrum antiviral activity
2023 - 2027 Precise Synthesis of 1,2-cis Furanosides by Boron-Mediated Aglycon Delivery and Their Application
2020 - 2026 Activation of ionic intermediates by a Lewis-acid external stimulus system
2019 - 2023 非対称化型1,2-cis-立体選択的グリコシル化法の開発と有用糖質合成への応用
2020 - 2022 有機化学を基盤とした人獣共通感染症に対する複合糖質ワクチン開発への挑戦

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Papers (97)：

Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba, Shuhei Kosono, Maniyamma Aswathy, Itsuki Anzai, Tokiko Watanabe, Kazunobu Toshima, Daisuke Takahashi. Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection. Angewandte Chemie (International ed. in English). 2024. e202411760
*DAISUKE TAKAHASHI, Kazunobu Toshima. Total Synthesis of Mannosylerythritol Lipids and Structure-Function Relationship Studies. JOURNAL OF OLEO SCIENCE. 2024. 73. 4. 539-546
Katsunori Seki, Takumi Makikawa, *Kazunobu Toshima, *DAISUKE TAKAHASHI. Synthesis and Immunological Evaluation of Escherichia coli O1- Derived Oligosaccharide-Protein Conjugates toward Avian Pathogenic Escherichia coli O1 Vaccine Development. SYNTHESIS. 2023. 56. 06. 953-965
*Kazunobu Toshima, DAISUKE TAKAHASHI, Yuka Isozaki. Photo-Induced Glycosylations Using Organophotoacids: A New Environmentally Benign Carbohydrate Synthesis. SYNLETT. 2023. 35. 777-788
Kazuki Inaba, Yuna Naito, Mina Tachibana, *Kazunobu Toshima, *DAISUKE TAKAHASHI. Regioselective and Stereospecific β-Arabinofuranosylation by Boron-Mediated Aglycon Delivery. ANGEWANDTE CHEMIE - INTERNATIONAL EDITION. 2023

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MISC (11)：

高橋大介. 有機化学を基盤とした鳥類病原性大腸菌に対する複合糖質ワクチン開発への挑戦. 日生研たより. 2023. 69. 2. 3-11
久保木佑哉, 杉本葵, 角田菜月, 吉本紗良, 安齋樹, 渡辺登喜子, 戸嶋一敦, 高橋大介. Synthesis of fucoidan derivatives and their entry-inhibitory activities against Ebola virus. 日本糖質学会年会要旨集. 2023. 42nd
杉本葵, 久保木佑哉, 小池樹, 安齋樹, 渡辺登喜子, 戸嶋一敦, 高橋大介. Synthesis of fucoidan derivative and its inhibitory activity against SARS-CoV-2 infection. 日本糖質学会年会要旨集. 2022. 41st
*高橋大介, *戸嶋一敦. 架橋構造をもつ糖. 月刊化学. 2020. 75. 2. 72-73
Daisuke Takahashi. Direct and Stereoselective Synthesis of beta-Mannosides by Anomeric O-Alkylation. TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY. 2016. 28. 164. E119-E120

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Patents (5)：

新規な抗生物質及びその製造方法
抗腫瘍剤
ノイラミニダーゼに対する酵素阻害剤
糖鎖アレイ及びその製造方法
N-グリコシルアミドの製造方法

Books (6)：

Comprehensive Glycoscience 2nd edition
Elsevier 2021 ISBN:9780128222447
糖鎖の新機能開発・応用ハンドブック
エヌ・ティー・エス 2015
糖鎖の新機能開発・応用ハンドブック
エヌ・ティー・エス 2015
機能性配糖体の合成と応用-糖転移酵素を中心に-
シーエムシー出版 2013
Green Solvents II: Properties and Applications of Ionic Liquids
Springer 2012

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Lectures and oral presentations (288)：

エンジイン系抗生物質N1999A2を基本骨格としたがん細胞応答型光感受性分子の創製
(日本化学会第104春季年会(2024) 2024)
ホウ素媒介アグリコン転移反応を用いたアレルギー抑制活性糖質の創製研究
(日本化学会第104春季年会(2024) 2024)
可食性ポリフェノールクルクミンを活性化剤に用いたN-光グリコシル化反応の開発
(日本化学会第104春季年会(2024) 2024)
セラノスティクスを指向したがん細胞応答型光感受性分子-蛍光分子ハイブリッドの創製
(日本化学会第104春季年会(2024) 2024)
可食性ポリフェノールエラグ酸を活性化剤に用いた光グリコシル化反応の開発
(GlycoTOKYO2023 2023)

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Education (3)：

2001 - 2006 Tokyo Institute of Technology Graduate School of Science and Technology Department of Applied Chemistry
2001 - 2006 Tokyo Institute of Technology Graduate School of Science and Technology Department of Applied Chemistry
1997 - 2001 Tokyo Institute of Technology Faculty of Engineering Applied chemistry

Professional career (2)：

博士(工学) (東京工業大学)
Ph.D. (Tokyo Institute of Technology)

Work history (7)：

2016/04/01 - 現在 Keio University Department of Applied Chemistry, Faculty of Science and Technology Associate Professor
2012/04/01 - 2016/03/31 Keio University Department of Applied Chemistry, Faculty of Science and Technology Assistant Professor
2011/04/01 - 2012/03/31 Keio University Department of Applied Chemistry, Faculty of Science and Technology Research Associate
2008/04/01 - 2011/03/31 Keio University Department of Applied Chemistry, Faculty of Science and Technology Research Associate (Non-tenured)
2007/04 - 2008/03 Carlsberg Laboratory, Postdoctoral Fellow

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Committee career (45)：

2023/03 - 現在日本化学会代表正会員
2023/01 - 現在 Trends in Glycoscience and Glycotechnology Associate Editor
2022/10 - 現在第43 回日本糖質学会年会実行委員会世話人
2023/01 - 2028/12 FCCA (Forum: Carbohydrates Coming of Age) TIGGトピック担当幹事
2023/01 - 2028/12 FCCA (Forum: Carbohydrates Coming of Age) 幹事会員

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Awards (9)：

2023/12 - The Organizing Committee of the 16th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-16) 2023 Asian Core Program Lectureship Award Efficient Synthesis of Biologically Active Glycosides by Boron-Mediated Aglycon Delivery and Their Applications in Chemical Biology
2022/06 - Japan Oil Chemists' Society Oleomaterial Division Oleomaterial award Efficient Total Synthesis of Mannosylerythritol Lipids and Their Structure-Function Studies
2021/04 - The Editorial Board and Publisher of Carbohydrate Research The Carbohydrate Research Award for Creativity in Carbohydrate Chemistry The Work on Glycosylation Chemistry, Having Developed Novel and Expedient Boron-Mediated Processes for the Stereoselective Synthesis of Glycosides
2017/02/16 - The Society of Synthetic Organic Chemistry, Japan Incentive Award in Synthetic Organic Chemistry, Japan (2016) Precise Synthesis and Chemical Biological Studies of Certain Carbohydrates, and Creation of Artificial Bio-functional Molecules
2016/09 - The Japanese Society of Carbohydrate Research 2016 Incentive Award in the Japanese Society of Carbohydrate Research Target-Selective Synthesis and Photodegradation of Oligosaccharides Utilizing Chemical Properties of Organoboronic Acids

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Association Membership(s) (7)：

日本化学会、会員 , 日本糖質学会、会員 , 有機合成化学協会、会員 , 日本ケミカルバイオロジー学会、会員 , FCCA (Forum: Carbohydrates Coming of Age), member , American Chemical Society, member , Japan Oil Chemists' Society, member

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