Rchr
J-GLOBAL ID:200901060862931140   Update date: Dec. 25, 2025

Daisuke Takahashi

タカハシ ダイスケ | Daisuke Takahashi
Affiliation and department:
Job title: Associate Professor
Homepage URL  (2): http://www.applc.keio.ac.jp/~toshima/takahashi.htmlhttps://www.st.keio.ac.jp/en/tprofile/applc/takahashi.html
Research field  (9): Chemical biology ,  Molecular biochemistry ,  Bioorganic chemistry ,  Synthetic organic chemistry ,  Pharmaceuticals - chemistry and drug development ,  Structural/physical organic chemistry ,  Bioorganic chemistry ,  Bioorganic chemistry ,  Structural/physical organic chemistry
Research keywords  (6): 構造活性相関 ,  Glycosylated Natural Products ,  Chemical Biology ,  Glycosylation Reaction ,  Synthetic Organic Chemistry ,  Carbohydrate Chemistry
Research theme for competitive and other funds  (20):
  • 2025 - 2030 精密糖鎖合成を基盤とした次世代創薬モダリティーの創出
  • 2022 - 2028 Establishment of platforms for drug discovery and development of novel drugs with broad-spectrum antiviral activity
  • 2023 - 2027 Precise Synthesis of 1,2-cis Furanosides Using Boron-Mediated Aglycon Delivery and Its Application
  • 2023 - 2027 Precise Synthesis of 1,2-cis Furanosides by Boron-Mediated Aglycon Delivery and Their Application
  • 2020 - 2026 Activation of ionic intermediates by a Lewis-acid external stimulus system
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Papers (113):
  • Yuka Isozaki, Ali Ahsan Muzahid, Tatsuki Wakata, Maho Fujino, Yoshikazu Tanaka, Chigusa Hayashi, Yoshimasa Ishizaki, Tomokazu Ohishi, Ayumi Morita, Shunichi Ohba, et al. Synthesis and structure-activity relationship of azithromycin derivatives against non-tuberculous mycobacteria. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2025
  • Hidenari Shigeta, Ayato Watanabe, Chikako Shiraishi, DAISUKE TAKAHASHI, Kazunobu Toshima. Glycosylation Using Diethyl Phosphite Donor Activated by Edible Polyphenol Ellagic Acid. CARBOHYDRATE RESEARCH. 2025. 558. 109712 (6 pages)
  • Shuting Ji, Maniyamma Aswathy, Yuya Kuboki, Yoshio Takada, Kazunobu Toshima, DAISUKE TAKAHASHI, *Hiroko Ideo. Inhibitory Effect of Fucoidan Analogs on Highly Metastatic Gastric Cancer Cells via Galectin-4 Inhibition. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2025. 26. 18. 9228
  • Yusha Li, Yuki Masuda, Yuzuha Miyazawa, DAISUKE TAKAHASHI, *Kazunobu Toshima. An alkaline phosphatase-activatable photosensitizer based on 2-anthrol for selective targeting of cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY. 2025. 129. 130371-130371
  • Yuka Isozaki, *Kazunobu Toshima, *DAISUKE TAKAHASHI. Boron-mediated aglycon delivery for late-stage modifications: applications in chemical biology and pharmaceutical lead development. CHEMISTRY LETTERS. 2025. 54. 5. upaf088 (9 pages)
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MISC (11):
Patents (5):
  • 新規な抗生物質及びその製造方法
  • 抗腫瘍剤
  • ノイラミニダーゼに対する酵素阻害剤
  • 糖鎖アレイ及びその製造方法
  • N-グリコシルアミドの製造方法
Books (8):
  • Modern Natural Product Synthesis -Overcoming Difficulties
    Springer Nature 2024
  • Advances in Carbohydrate Chemistry and Biochemistry
    Elsevier 2022
  • Comprehensive Glycoscience 2nd edition
    Elsevier 2021 ISBN:9780128222447
  • 糖鎖の新機能開発・応用ハンドブック
    エヌ・ティー・エス 2015
  • 糖鎖の新機能開発・応用ハンドブック
    エヌ・ティー・エス 2015
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Lectures and oral presentations  (343):
  • Efficient Synthesis of Useful Carbohydrates and SAR Studies Toward the Creation of Pharmaceutical Leads
    (Taiwan Glycoscience Alliance Lecture 2025 (Academia Sinica) 2025)
  • Synthesis of Useful Carbohydrates and SAR Studies Toward the Creation of Pharmaceutical Leads
    (Taiwan Glycoscience Alliance Lecture 2025 (National Chung Hsing University) 2025)
  • Synthesis of Biologically Active Carbohydrates and SAR Studies Toward the Creation of Pharmaceutical Leads
    (Taiwan Glycoscience Alliance Lecture 2025 (National Tsing Hua University) 2025)
  • ホウ素媒介アグリコン転移を用いたα-GOSの全合成と免疫賦活活性に関 する構造活性相関研究
    (第9回FCCAシンポジウム グライコサイエンス若手フォーラム2025 2025)
  • 2-アントロールを基本骨格としたがん細胞応答型光感受性分子の創製
    (第47回日本光医学・光生物学会 2025)
more...
Education (4):
  • 2003 - 2006 Tokyo Institute of Technology Graduate School of Science and Technology Department of Applied Chemistry
  • 2001 - 2006 Tokyo Institute of Technology Graduate School of Science and Technology Department of Applied Chemistry
  • 2001 - 2006 Tokyo Institute of Technology Graduate School of Science and Technology Department of Applied Chemistry
  • 1997 - 2001 Tokyo Institute of Technology Faculty of Engineering Applied chemistry
Professional career (1):
  • Ph.D. (Tokyo Institute of Technology)
Work history (19):
  • 2016/04 - 現在 Keio University Associate Professor(Department of Applied Chemistry, Faculty of Science and Technology)
  • 2023/10 - 2025/09 慶應義塾大学 理工学部 安全衛生委員会・委員(基礎教室)
  • 2023/10 - 2025/09 慶應義塾大学 理工学部 学習指導副主任(基礎教室)
  • 2023/10 - 2025/09 慶應義塾大学 理工学部 学生総合センター(就職担当)・委員
  • 2022/03 - 2023/03 慶應義塾大学 大学院理工学研究科 大学院専攻・専修組織改革検討委員会・委員
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Committee career (55):
  • 2025/06 - 現在 第33回IUPAC国際天然物化学会議組織委員会 委員
  • 2023/03 - 現在 日本化学会 代表正会員
  • 2023/01 - 現在 日本糖質学会誌 Trends in Glycoscience and Glycotechnology Associate Editor
  • 2023/01 - 現在 Trends in Glycoscience and Glycotechnology Associate Editor
  • 2023/01 - 2028/12 FCCA (Forum: Carbohydrates Coming of Age) TIGGトピック担当幹事
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Awards (13):
  • 2023/12 - The Organizing Committee of the 16th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-16) 2023 Asian Core Program Lectureship Award Efficient Synthesis of Biologically Active Glycosides by Boron-Mediated Aglycon Delivery and Their Applications in Chemical Biology
  • 2022/08 - Japan Oil Chemists' Society Oleomaterial Division Oleomaterial award Efficient Total Synthesis of Mannosylerythritol Lipids and Their Structure-Function Studies
  • 2022/06 - Japan Oil Chemists' Society Oleomaterial Division Oleomaterial award Efficient Total Synthesis of Mannosylerythritol Lipids and Their Structure-Function Studies
  • 2021/04 - The Editorial Board and Publisher of Carbohydrate Research The Carbohydrate Research Award 2021
  • 2021/04 - The Editorial Board and Publisher of Carbohydrate Research The Carbohydrate Research Award for Creativity in Carbohydrate Chemistry The Work on Glycosylation Chemistry, Having Developed Novel and Expedient Boron-Mediated Processes for the Stereoselective Synthesis of Glycosides
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Association Membership(s) (15):
日本応用糖質科学会(会員) ,  日本応用糖質科学会、会員 ,  日本バイオサーファクタント勉強会(設立コアメンバー) ,  Japan Oil Chemists' Society, member ,  American Chemical Society, member ,  FCCA (Forum: Carbohydrates Coming of Age) (member) ,  FCCA (Forum: Carbohydrates Coming of Age), member ,  日本ケミカルバイオロジー学会(会員) ,  日本ケミカルバイオロジー学会、会員 ,  有機合成化学協会(会員) ,  有機合成化学協会、会員 ,  日本糖質学会(会員) ,  日本糖質学会、会員 ,  日本化学会(会員) ,  日本化学会、会員
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