Arai Yasuhito

アライヤスヒト | Arai Yasuhito

Affiliation and department：
Job title： Chief Researcher
Homepage URL (1)： https://www.ncc.go.jp/jp/ri/division/cancer_genomics/index.html

Research field (1)： Molecular biology

Research keywords (5)：ゲノム , Biliary tract cancer , がん抑制遺伝子 , がん遺伝子 , Cancer genomics

Research theme for competitive and other funds (7)：

2018 - 2021 Molecular classification of biliary cancer by transcriptome analysis of FFPE specimens
2018 - 2021 Decelopment of nect generation precision theraoy for oral cancer by single cell analysis of oral cancer CTCs
2015 - 2018 Revealing cancer-cell evolution and intra-tumor heterogeneity by single-cell genome and transcriptome analysis
2014 - 2017 Whole transcriptome analysis and novel therapeutic targets in biliary tract cancer
2013 - 2016 Identification of novel fusion genes in gastric cancer by whole transcriptome sequencing: Discovery of potential therapeutic targets for gastric cancer

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Papers (69)：

Hirofumi Rokutan, Yasuhito Arai, Akiko Kunita, Satoshi Yamasaki, Hiromi Nakamura, Natsuko Hama, Atsuhito Nakayama, Fumie Hosoda, Yasushi Totoki, Mitsuhiro Fujishiro, et al. Genomic and Pathologic Profiling of Very Well-Differentiated Gastric Adenocarcinoma of Intestinal Type: A Study With Emphasis on Diffuse-Type Transformation. The American journal of surgical pathology. 2024. 48. 6. 652-661
Akihiko Fukagawa, Natsuko Hama, Yasushi Totoki, Hiromi Nakamura, Yasuhito Arai, Mihoko Saito-Adachi, Akiko Maeshima, Yoshiyuki Matsui, Shinichi Yachida, Tetsuo Ushiku, et al. Genomic and epigenomic integrative subtypes of renal cell carcinoma in a Japanese cohort. Nature Communications. 2023. 14. 1
Kana Shimomura, Naoko Hattori, Naoko Iida, Yukari Muranaka, Kotomi Sato, Yuichi Shiraishi, Yasuhito Arai, Natsuko Hama, Tatsuhiro Shibata, Daichi Narushima, et al. Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development. Nature Communications. 2023. 14. 1
Kana Shimomura, Naoko Hattori, Naoko Iida, Yukari Muranaka, Kotomi Sato, Yuichi Shiraishi, Yasuhito Arai, Natsuko Hama, Tatsuhiro Shibata, Daichi Narushima, et al. Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development. Nature communications. 2023. 14. 1. 6514-6514
Mihoko Saito-Adachi, Natsuko Hama, Yasushi Totoki, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Hirofumi Rokutan, Shinichi Yachida, Mamoru Kato, Akihiko Fukagawa, et al. Oncogenic structural aberration landscape in gastric cancer genomes. Nature communications. 2023. 14. 1. 3688-3688

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MISC (25)：

新井康仁, 中村浩実, 十時泰, 濱奈津子, Elzawahry Asmaa, 加藤護, 細田文恵, 尾島英知, 島田和明, 森実千種, et al. 肝胆膵腫瘍の新たな診断・治療胆道癌の網羅的ゲノム解析と新たな治療法の開発. 日本癌学会総会記事. 2017. 76回. SST3-3
新井康仁, 中村浩実, 十時泰, 濱奈津子, 尾島英知, 細田文恵, 島田和明, 森実千種, 奥坂拓志, 柴田龍弘. 胆道がんにおけるドライバー融合遺伝子の解析. 日本癌学会総会記事. 2016. 75回. E-1021
十時泰, 藤本明洋, 中村浩実, 濱奈津子, 細田文恵, 新井康仁, 中川英刀, 柴田龍弘. 肝がんの体細胞変異シグネチャーと臨床的背景との関連. 日本癌学会総会記事. 2016. 75回. J-1013
Shinichi Yachida, Laura D. Wood, Masami Suzuki, Erina Takai, Yasushi Totoki, Mamoru Kato, Claudio Luchini, Yasuhito Arai, Hiromi Nakamura, Natsuko Hama, et al. Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma. Cancer Cell. 2016. 29. 229-240
新井康仁, 中村浩実, 十時泰, 代田智樹, 濱奈津子, 尾島英知, 細田文恵, 島田和明, 森実千種, 奥坂拓志, et al. 網羅的シークエンス解析による胆管がん分子標的の同定. 日本癌学会総会記事. 2015. 74回. J-1213

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Books (1)：

ゲノム解析とがん:現代医学の基礎第10巻 p249-261
岩波書店 1999

Education (4)：

- 1990 Waseda University
- 1990 Waseda University Graduate School, Division of Science and Engineering
- 1987 Waseda University School of Education
- 1987 Waseda University Faculty of Education

Professional career (1)：

Ph.D. (Waseda University)

Association Membership(s) (4)：

日本分子生物学会 , 日本癌学会 , Molecular Biology Society of Japan , Japanese Cancer Association

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