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J-GLOBAL ID：200901061064463710   Update date: Sep. 26, 2024

NAGAYAMA Kazuaki

ナガヤマ カズアキ | NAGAYAMA Kazuaki
Affiliation and department：
Ibaraki University Graduate School of Science and Engineering (Engineering) Department of Mechanical Engineering

About Ibaraki University Graduate School of Science and Engineering (Engineering) Department of Mechanical Engineering


Job title： Professor
Research field  (7)： Machine materials and mechanics ,  Biomaterials ,  Biomaterials ,  Machine materials and mechanics ,  Biophysics ,  Biomedical engineering ,  Biomedical engineering
Research keywords  (3)： マイクロ・ナノサイエンス ,  細胞骨格、細胞核、DNA ,  バイオメカニクス、メカノバイオロジー、生体医工学、生体材料
Research theme for competitive and other funds  (23)：
  • 2022 - 2024 細胞の「構造と力」の記憶と崩壊のスイッチング
  • 2021 - 2024 機能ゲノミクス解析とハイスループット解析を用いた線維性異形成症新規治療法開発
  • 2021 - 2024 血管壁の恒常性維持と病態形成におけるメカノトランスダクション機序の解明
  • 2021 - 2024 細胞骨格と核の「繋がり」に基づく細胞の恒常性維持機構の解明
  • 2021 - 2022 茨城大学特色研究加速イニシアティブ「生体組織に備わるとされる力学的適応能力に関する研究」
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Papers (144)：
  • Inducement of cell tissue arrangement and vascular smooth muscle differentiation,Abstract using micro-grooved concaves,. 2023. 89. 920-23-00004. 1-11
  • Kazuaki NAGAYAMA, Tatsuya HANZAWA, Akiko SATO. Superficial groove structure in the size of focal adhesion can clarify cell-type-specific differences in force-dependent substrate mechanosensing,. Journal of Biomechanical Science and Engineering. 2023. 18. 3. 22--00474
  • Katsuta H, Okuda S, Nagayama K, Machiyama H, Kidoaki S, Kato M, Sokabe M, Miyata T, Hirata H. Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers,. iScience. 2023. 26. 3. 106090-106090
  • Nagayama K, Kodama F, Wataya N, Sato A, Matsumoto T. Changes in the intra- and extra- mechanical environment of the nucleus in Saos-2 osteoblastic cells during bone differentiation process:Nuclear shrinkage and stiffening in cell differentiation,. Journal of the Mechanical Behavior of Biomedical Materials. 2023. 138. 105630. 1-11
  • Yamashiro Y, Ramirez K, Nagayama K, Hattori N, Liu Y, Matsunaga S, Tomita S, Kubota Y, Yanagisawa H. Partial endothelial-to-mesenchymal transition (EndMT) mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation,. Cardiovascular Research. 2022. in press
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MISC (100)：
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Books (5)：
  • Vascular Engineering, New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach.
    Springer. 2016 ISBN:9784431548003
  • On the roles of actin stress fibers on the mechanical environment of nucleus in vascular smooth muscle cells, Recent Advances in Mechanobiology.
    Shanghai Scientific and Technological Literature Publishing House (Editor-in-Chief: Shu Chien, Shi Yongde, and Masahiro Sokabe). 2012
  • Effects of cytoskeletal structures on elastic and viscoelastic properities of cells in soft tissues, Biomechanics at Micro- and Nanoscale Levels, Volume IV.
    World Scientific, Singapore. 2007
  • Measurement of Mechanical Properties of Cells Considering Their Intracellular Microstructures, Biomechanics at Micro- and Nanoscale Levels, Volume II.
    World Scientific, Singapore. 2006
  • Microscopic Analysis of Residual Stress and Strain in the Aortic Media Considering Anisotropy of Smooth Muscle Layer, Holzapfel GA, Ogden RW, eds, Mechanics of Biological Tissue.
    Springer-Verlag. 2006
Lectures and oral presentations  (212)：
  • 局所的圧縮刺激培養系の構築と細胞のDNA損傷解析(力学的刺激のバイスタンダー効果による細胞癌化可能性),
    (日本機械学会東北支部第59期総会・講演会, 2024)
  • Cell nucleus segmentation and cell type classification from stain-free phase-contrast images enabled by machine learning,
    (2024)
  • Effects of changes in intracellular structure and cellular organization induced by mechanical stimulation on wound healing process,
    (2024)
  • Evaluation for Frictional Force to Elucidate Anti-fouling Function of Nanostructure of Biplogical Surfaces,
    (2024)
  • Development of force sensor used cells introduced with fluorescence resonance energy transfer (FRET),
    (2024)
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Education (3)：
  • 1996 - 1998 Tohoku University Graduate School, Division of Engineering 機械電子工学専攻
  • 1996 - 1998 Tohoku University Graduate School, Division of Engineering 機械電子工学専攻
  • 1992 - 1996 Tohoku University Faculty of Engineering 機械知能工学科
Professional career (1)：
  • Ph.D. (Nagoya Institute of Technology)
Work history (7)：
  • 2018/04 - Ibaraki University Department of Mechanical Systems Engineering, Professor
  • 2014/04 - 2018/03 Ibaraki University Department of Intelligent Systems Engineering Professor
  • 2013/04 - 2014/03 Nagoya Institute of Technology Department of Nanomedicine Science, Graduate School of Engineering Associate Professor
  • 2010/04 - 2013/03 Nagoya Institute of Technology Department of Techno-Business Administration, Graduate School of Engineering Associate Professor
  • 2007/04 - 2010/03 Nagoya Institute of Technology Department of Engineering Physics, Electronics and Mechanics, Graduate School of Engineering Assistant Professor
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Committee career (11)：
  • 2021/04 - 2023/03 日本機械学会 日本機械学会論文集/Transactions of the JSME Mechanical Engineering Journal「生体工学,医工学,スポーツ工学,人間工学 (Bio, Medical, Sports and Human Engineering)」分野アソシエイトエディタ
  • 2021/04 - 2023/03 日本機械学会 バイオエンジニアリング部門・総務委員長
  • 2018/04 - 2020/03 ライフサポート学会 評議員
  • 2018/04 - 2020/03 日本機械学会 バイオエンジニアリング部門・企画委員長
  • 2014/04 - 2019/03 日本機械学会 日本機械学会英文誌 Journal of Biomechanical Science and Engineering編集委員
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Awards (19)：
  • 2022/12 - 日本生体医工学会関東支部若手研究者発表会2022・優秀論文発表賞 「大橋未来,竹田晃人,長山和亮:機械学習を用いた無染色位相差顕微鏡画像からの細胞核抽出と評価,日本生体医工学会関東支部若手研究者発表会2022, 2022.12.10」に対して
  • 2022/08 - 日本機械学会関東支部2022年度茨城講演会・優秀講演賞 「綿谷直樹,長山和亮:マイクロ溝基板を用いた細胞の形態制御と細胞内部構造の3次元解析,日本機械学会関東支部2022年度茨城講演会, 2022.8.19」に対して,
  • 2022/04 - 2021年度 日本機械学会賞(論文) 「Nagayama K: Biomechanical analysis of the mechanical environment of the cell nucleus in serum starvation-induced vascular smooth muscle cell differentiation, Journal of Biomechanical Science and Engineering 14(4): 19-00364, 2019」 に対して
  • 2022/03 - 日本機械学会関東学生会第60回卒業研究発表講演会 Best Presentation Award 「廣岡祐仁,上杉 薫,長山和亮:細胞間の力学的相互作用が細胞の紫外線耐性に与える影響~細胞密度および細胞種の違いによる応答変化~,日本機械学会関東学生会第60回卒業研究発表講演会, 2022.3.14」に対して,
  • 2022/03 - 日本機械学会関東支部・若手優秀講演賞 「綿谷直樹,上杉 薫,長山和亮:細胞配列化と繰返引張刺激による血管平滑筋細胞の分化誘導への試み,日本機械学会 関東支部 第28期総会・講演会, 2022.3.15」に対して,
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Association Membership(s) (8)：
ライフサポート学会 ,  Biophysical Society ,  Biomedical Engineering Society ,  日本生物物理学会 ,  American Physiological Society ,  日本再生医療学会 ,  日本生体医工学会 ,  日本機械学会
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