Shibuya Hiroshi

シブヤヒロシ | Shibuya Hiroshi

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.tmd.ac.jp/mri/mri-mcb/index_j.html

Research field (2)： Cell biology , Molecular biology

Research keywords (2)：シグナル伝達 , Cellular Signal Transduction

Research theme for competitive and other funds (16)：

2021 - 2024 Regulation of neural differentiation in Wnt signaling by WNK.
2018 - 2021 Regulation of neural differentiation in Wnt signaling by WNK.
2011 - 2014 Characterization of WNK signaling in development
2005 - 2009 Regulation of DECODE system in Development
2005 - 2009 Quantitation analysis of pathway network analysis

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Papers (31)：

Michiru Nishita, Koki Kamizaki, Kyoka Hoshi, Kana Aruga, Ikumi Nishikaku, Hiroshi Shibuya, Kunio Matsumoto, Yasuhiro Minami. Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression. Journal of Biological Chemistry. 2023. 105248-105248
Toshiyasu Goto, Hiroshi Shibuya. maea affects head formation through ß-catenin degradation during early Xenopus laevis development. Development, growth & differentiation. 2022
Toshiyasu Goto, Tatsuo Michiue, Hiroshi Shibuya. ccr7 affects both morphogenesis and differentiation during early Xenopus embryogenesis. Development, growth & differentiation. 2022. 64. 5. 254-260
Toshiyasu Goto, Junhei Matsuzawa, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya. WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway. FEBS LETTERS. 2016. 590. 9. 1291-1303
Takashi Fukuzono, Strahil Iv. Pastuhov, Okinobu Fukushima, Chun Li, Ayuna Hattori, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya, Hiroshi Hanafusa, Kunihiro Matsumoto, et al. Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi. GENES TO CELLS. 2016. 21. 4. 311-324

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MISC (54)：

Mi-Sun Kim, Takeshi Kondo, Ichiro Takada, Min-Young Youn, Yoko Yamamoto, Sayuri Takahashi, Takahiro Matsumoto, Sally Fujiyama, Yuko Shirode, Ikuko Yamaoka, et al. DNA demethylation in hormone-induced transcriptional derepression (Retracted article. See vol. 486, pg. 280, 2012). NATURE. 2009. 461. 7266. 1007-1012
M. Kim, F. Ohtake, I. Takada, K. Takeyama, H. Shibuya, S. Kato. DNA Demethylation for Hormone-Induced Transcriptional Derepression. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S52-S52
Sung-Sen Yang, Tetsuji Morimoto, Tatemitsu Rai, Motoko Chiga, Eisei Sohara, Mayuko Ohno, Keiko Uchida, Shih-Hua Lin, Tetsuo Moriguchi, Hiroshi Shibuya, et al. Molecular pathogenesis of pseudohypoaldosteronism type II: Generation and analysis of a Wnk4(D561A/+) knockin mouse model. CELL METABOLISM. 2007. 5. 5. 331-344
YAMADA Misato, YAMADA Misato, OHNISHI Junji, OHNISHI Junji, OHKAWARA Bisei, OHKAWARA Bisei, IEMURA Shunichiro, SATOH Kiyotoshi, SATOH Kiyotoshi, HYODO-MIURA Junko, et al. NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). J Biol Chem. 2006. 281. 30. 20749-20760
MORIGUCHI Tetsuo, MORIGUCHI Tetsuo, URUSHIYAMA Seiichi, HISAMOTO Naoki, IEMURA Shun-ichiro, UCHIDA Shinichi, NATSUME Tohru, MATSUMOTO Kunihiro, SHIBUYA Hiroshi, SHIBUYA Hiroshi. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. JOURNAL OF BIOLOGICAL CHEMISTRY. 2005. 280. 52. 42685-42693

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Education (2)：

- 1983 University of Tsukuba Master's Program in Environmental Sciences
- 1983 University of Tsukuba Second Cluster of College

Professional career (1)：

(BLANK) (Osaka University)

Work history (1)：

2000 - 現在 Tokyo Medical and Dental University Medical Research Institute

Awards (1)：

1998 - 日本生化学会奨励賞

Association Membership(s) (1)：

日本分子生物学会

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