Rchr

J-GLOBAL ID：200901061383897995 Update date: Feb. 01, 2024

Komatuzawa Hitoshi

コマツザワヒトシ | Komatuzawa Hitoshi

Affiliation and department：
Job title： Associate Professor

Research field (1)： Oral medicine

Research theme for competitive and other funds (47)：

2021 - 2024 口腔由来高度多剤耐性黄色ブドウ球菌のリスク診断法確立に向けた基盤研究
2021 - 2024 Comprehensive study on the effects of periodontal pathogen on the pathophysiology of atrial fibrillation
2020 - 2023 口腔内耐性菌の分布の把握と歯科による口腔衛生管理が医療・介護関連肺炎に及ぼす影響
2020 - 2023 口腔細菌を標的としたがん化学療法における全身合併症予防システムの構築
2020 - 2023 歯周病原因菌の病原性因子及び挿入配列を制御するsmall RNAの解析

2019 - 2023 胃内と口腔内の常在細菌叢、ブラキシズム及び胃食道逆流との関連性の解明

2019 - 2023 顎骨骨髄炎発症要因における歯原性細胞と細胞極性調節因子相互作用の解析

2020 - 2022 Development of a new method for dental caries prevention by bacteriophage

2018 - 2021 Effects of the incretin-related drug on periodontopathic bacteria in type 2 diabetes

2018 - 2021 Search for naturally-deribved prebiotic factors that inhibit oral colonization of multidrug-resistant S. aureus

2017 - 2020 Identification of bioactive peptides producing by A. actinomycetemcomitans

2016 - 2019 Association analysis of different cell interaction and cell polarity regulator and infection protective ability in odontogenic infection

2016 - 2019 口腔内マイクロバイオーム形成機序および宿主免疫に及ぼす影響の解明

2015 - 2018 Fundamental research toward development of infection prevention against oral cavity-derived multidrug resistant Staphylococcus aureus

2013 - 2016 Immunohistochemical and cell biological studies on the epithelial lining in periapical lesions - expression of epithelial mesenchymal transition (EMT) markers and antimicrobial peptides -

2013 - 2016 Analysis for the existence of cariogenic and periodontal bacteria in oral cavity

2012 - 2014 The analysis of molecular mechanism of bone destruction using invitro cocultivation assay and application to a risk management in ameloblastoma

2010 - 2012 サイトカインは直接的に細菌に作用するのか?

2010 - 2012 Study of the defense mechanism against infection of dental epithelial cell

2010 - 2012 Effect to immunoresponse of antibacterial peptides

2007 - 2009 歯周病原因菌とヒト抗菌ペプチドの相互作用に関する研究

2007 - 2009 黄色ブドウ球菌の病原性因子発現に影響を及ぼす外来性因子に関する研究

2006 - 2009 Development of oral care during pregnancy for prevention of premature births

2007 - 2008 Study on the interaction between periodontal bacteria and human antimicrobial peptides

2006 - 2007 Regeneration of Pulp-dentin Complex by Antimicrobial Peptides

2005 - 2006 Investigation of bacteriolytic enzyme effect to oral streptococci clinical isolation

2005 - 2006 Integrated Research on pathogenic factors of periodontal pathogens

2005 - 2006 Interaction of sugar metabolism with antibiotic susceptibility in Staphylococcus aureus

2003 - 2004 Genomics and post-genomics of Staphylococcus aureus causing bullous impetigo

2002 - 2003 S.mutans,S.sobrinusを選択的に溶解する溶菌酵素の研究

2002 - 2003 Investigation of antibiotic resistance by total analysis of cell wall biosynthesis in methicillin-resistant

2001 - 2001 致死活性を有する新奇表皮剥脱毒素の作用機構に関する研究

2000 - 2001 黄色ブドウ球菌のメチシリンおよびバンコマイシン耐性に関与する因子についての研究

2000 - 2001 A study on the function of cell-cycle specific inhibitor, CDT

1999 - 1999 病原大腸菌が産生する毒素CNFの基質特異性についての研究

1998 - 1999 メチシリン耐性黄色ブドウ球菌のβ-ラクタム剤耐性に影響を及ぼす因子についての研究

1995 - 1996 DEVELOPMENT OF NEW ANTIMICROBIAL PEPTIDE AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS

1995 - 1995 界面活性剤併用によるMRSAの抗生物質感受性変化のメカニズムについての研究

1994 - 1994 界面活性剤併用によるMRSAの抗生物質感受性変化のメカニズムについての研究

1994 - 1994 メチシリン耐性黄色ブドウ球菌(MRSA)の溶菌耐性機構

1993 - 1993 メチシリン耐性黄色ブドウ球菌(MRSA)の薬剤耐性機構と病原性

口腔内細菌の産生する病原因子

細菌の産生するペプチドグリカン加水分解酵素

メチシリン耐性黄色ブドウ球菌の薬剤耐性機序

Pathogenic factor on oral bacteria

Peptidoglycan hydrolases at bacteria.

Mechanism of antibiotic resistance on methicillin-resistant staphylococcus aureus

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Papers (132)：

Satoru Kusaka, Azusa Haruta, Miki Kawada-Matsuo, Mi Nguyen-Tra Le, Mineka Yoshikawa, Toshiki Kajihara, Koji Yahara, Junzo Hisatsune, Ryota Nomura, Kazuhiro Tsuga, et al. Oral and rectal colonization of methicillin-resistant Staphylococcus aureus in long-term care facility residents and their association with clinical status. Microbiology and immunology. 2024
Katsuhito Sugai, Miki Kawada-Matsuo, Mi Nguyen-Tra Le, Yo Sugawara, Junzo Hisatsune, Jumpei Fujiki, Hidetomo Iwano, Kotaro Tanimoto, Motoyuki Sugai, Hitoshi Komatsuzawa. Isolation of Streptococcus mutans temperate bacteriophage with broad killing activity to S. mutans clinical isolates. iScience. 2023. 108465-108465
Kasumi Ishida-Kuroki, Junzo Hisatsune, Takaya Segawa, Yo Sugawara, Kanako Masuda, Kayoko Tadera, Seiya Kashiyama, Michiya Yokozaki, Mi Nguyen-Tra Le, Miki Kawada-Matsuo, et al. Complete genome sequence of cfr(B)-carrying Enterococcus raffinosus isolated from bile in a patient in Japan. Journal of Global Antimicrobial Resistance. 2023. 34. 43-45
Azusa Haruta, Miki Kawada-Matsuo, Mi Nguyen-Tra Le, Mineka Yoshikawa, Toshiki Kajihara, Koji Yahara, Norikazu Kitamura, Shoko Kutsuno, Chika Arai, Maho Takeuchi, et al. Disinfectant Susceptibility of Third-Generation-Cephalosporin/Carbapenem-Resistant Gram-Negative Bacteria Isolated from the Oral Cavity of Residents of Long-Term-Care Facilities. Applied and Environmental Microbiology. 2023. 89. 1
Yuri Taniguchi, Kazuhisa Ouhara, Masae Kitagawa, Keiichi Akutagawa, Miki Kawada-Matsuo, Tetsuya Tamura, Ruoqi Zhai, Yuta Hamamoto, Mikihito Kajiya, Shinji Matsuda, et al. Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model. Clinical and experimental immunology. 2022

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MISC (336)：

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Education (4)：

- 1992 Hiroshima University
- 1992 Hiroshima University Graduate School, Division of Dental Research
- 1989 Hiroshima University Faculty of Dentistry
- 1989 Hiroshima University Faculty of Dentistry

Professional career (1)：

博士(歯学) (広島大学)

Work history (2)：

2019/05 - 現在 Hiroshima University Graduate School of Biomedical and Health Sciences Professor
2008/03 - 2019/04 Kagoshima University Graduate School of Medical and Dental Sciences Professor

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