Rchr
J-GLOBAL ID:200901061386617640
Update date: Apr. 24, 2025
Nishimura Shigenori
ニシムラ シゲノリ | Nishimura Shigenori
Affiliation and department:
Homepage URL (1):
http://www.bioinfo.osakafu-u.ac.jp/~inuit/
Research field (3):
Biophysics
, Structural biochemistry
, Molecular biochemistry
Research keywords (6):
構造生物学
, 生物物理化学
, 蛋白質工学
, Structure biology
, Biophisycal chemistry
, Protein Engineering
Research theme for competitive and other funds (13):
- 2021 - 2025 Development of new drug for African trypanosomiasis based on elucidation of the mechanism of antiprotozoal action by ribavirin.
- 2017 - 2021 Molecular basis and development of transglycosylation reaction of maltotriose-forming amylase
- 2017 - 2020 Challenge for treatment of dog allergy by allergen immunotherapy using hypoallergenic vaccine
- 2014 - 2017 Molecular basis for the recognition of the substrate and for the transglycosylation reaction of an exo-type alpha-amylase.
- 2013 - 2016 Development of novel therapeutic agents against African sleeping sickness targeted for GMP reductase.
- 2010 - 2012 Structural andfunctional analysis of glycoside hydrolases with multiple catalytic domains.
- 1995 - 1997 Precise Heat Capacity Measurement of Dilute Protein Aqueous Solutions by AC-Calorimetry
- 1992 - Elucidation of the relationship between activity and structure of amylase
- 1988 - Determination of Protein Structure by Nuclear Magnetic Resonance
- リポカリン型プロスタグランジンD合成酵素(L-PGDS)の疎水性低分子結合蛋白質としての構造および機能解析
- 糖質関連酵素(アミラーゼ等)の構造と機能に関する研究
- 核磁気共鳴法を用いた蛋白質の構造解析
- トリパノソーマ由来 核酸代謝関連酵素の構造生物学
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Papers (28):
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Masatoshi Nakatsuji, Keisuke Sugiura, Keisuke Suda, Michiko Sakurai, Miki Ubatani, Haruka Muroya, Rina Okubo, Ryo Noguchi, Yoichi Kamata, Yuma Fukutomi, et al. Structure-based prediction of the IgE epitopes of the major dog allergen Can f 1. The FEBS journal. 2021. 289. 6. 1668-1679
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Akira Imamura, Tetsuya Okada, Hikaru Mase, Takuya Otani, Tomoka Kobayashi, Manatsu Tamura, Bruno Kilunga Kubata, Katsuaki Inoue, Robert P Rambo, Susumu Uchiyama, et al. Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-β-synthase domain. Nature communications. 2020. 11. 1. 1837-1837
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Kitaoku Y, Nishimura S, Hirono T, Suginta W, Ohnuma T, Fukamizo T. Structures and chitin-binding properties of two N-terminal lysin motifs (LysMs) found in a chitinase from Volvox carteri. Glycobiology. 2019. 29. 7. 565-575
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Kenji Yamamoto, Osamu Ishibashi, Keisuke Sugiura, Miki Ubatani, Masaya Sakaguchi, Masatoshi Nakatsuji, Shigeru Shimamoto, Masanori Noda, Susumu Uchiyama, Yuma Fukutomi, et al. Crystal structure of the dog allergen Can f 6 and structure-based implications of its cross-reactivity with the cat allergen Fel d 4. Scientific reports. 2019. 9. 1. 1503-1503
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Yuika Kunishige, Marin Iwai, Masami Nakazawa, Mitsuhiro Ueda, Toshiji Tada, Shigenori Nishimura, Tatsuji Sakamoto. Crystal structure of exo-rhamnogalacturonan lyase from Penicillium chrysogenum as a member of polysaccharide lyase family 26. FEBS Letters. 2018. 592. 8. 1378-1388
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MISC (97):
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若林光哉, 吉田はるな, 中辻匡俊, 中辻匡俊, 中辻匡俊, 下地真広, 古田航祐, 西村重徳, 乾隆. Structural Analysis of Multimeric Lipid-Transporter Protein by Small-Angle X-ray Scattering. SPring-8/SACLA利用研究成果集(Web). 2024. 12. 3
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松本彩佳, 竹内悠真, 西村重徳, 岡田哲也, 乾隆. In silicoスクリーニングによるTrypanosoma brucei由来GMP reductaseに対する新規アロステリック阻害剤の開発. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
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乾隆, 西村重徳, 竹内悠真. Trypanosoma brucei由来GMP reductaseとAMPとの複合体のX線結晶構造解析. 大阪公立大学研究推進機構放射線研究センター放射線施設共同利用報告書. 2022. 2021
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若林光哉, 吉田はるな, 下地真広, 大久保理奈, 中辻匡俊, 西村重徳, 乾隆. リポカリン型プロスタグランジンD合成酵素の多量体化による腫瘍標的ドラッグデリバリーシステムの開発. 日本生化学会大会(Web). 2022. 95th
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竹内悠真, 今村章, 岡田哲也, 馬瀬ひかる, 西村重徳, 乾隆. Trypanosoma brucei由来GMP reductaseとAMPとの複合体のX線結晶構造解析. 日本生化学会大会(Web). 2021. 94th
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Education (2):
- - 1987 Osaka University School of Science
- - 1987 Osaka University Faculty of Science
Professional career (1):
- (BLANK) (Osaka University)
Association Membership(s) (5):
THE JAPANESE SOCIETY OF APPLIED GLYCOSCIENCE
, THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN
, 日本蛋白質科学会
, 日本農芸化学会
, 日本生物物理学会
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