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J-GLOBAL ID：200901061634321923   Update date: Jan. 31, 2024

kasai haruo

カサイ ハルオ | kasai haruo
Affiliation and department：
The University of Tokyo WPI-IRCN

About The University of Tokyo WPI-IRCN


Homepage URL  (1)： http://www.bm2.m.u-tokyo.ac.jp/
Research field  (2)： Physiology ,  Neuroscience - general
Research keywords  (20)： dendritic spine synapse ,  シナプス可塑性 ,  学習・記憶 ,  レ-ザ-顕微鏡 ,  アクチン細胞骨格 ,  Ca画像処理 ,  グルタメイト ,  シナプス前終末 ,  パッチクランプ ,  生物・生体工学 ,  脳・神経 ,  開口放出 ,  イオンチャネル ,  シグナル伝達 ,  カルシウム ,  生理学 ,  シナプス ,  グルタミン酸受容体 ,  2光子励起 ,  ケイジド試薬
Research theme for competitive and other funds  (28)：
  • 2021 - 2026 シナプスの力学カップリングを担う軸索終末機構
  • 2020 - 2024 From spine structural biology to synapse mechanobiology with optical manipulation
  • 2020 - 2021 From structural plasticity of dendritic spines to synaptic mechano-biology
  • 2014 - 2019 大脳の記憶シナプスや回路の2光子顕微鏡と新規光プローブとを用いた研究
  • 2014 - 2017 Analysis of the properties of synaptic back propagating signal
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Papers (169)：
  • Haruo KASAI. Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition. Proceedings of the Japan Academy, Series B. 2023. 99. 8. 254-305
  • Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, et al. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. 2023. 12. RP89376
  • Haruo Kasai, Hasan Ucar, Yuichi Morimoto, Fumihiro Eto, Hitoshi Okazaki. Mechanical transmission at spine synapses: Short-term potentiation and working memory. Current Opinion in Neurobiology. 2023. 80. 102706-102706
  • Kenji Yamaguchi, Yoshitomo Maeda, Takeshi Sawada, Yusuke Iino, Mio Tajiri, Ryosuke Nakazato, Shin Ishii, Haruo Kasai, Sho Yagishita. A behavioural correlate of the synaptic eligibility trace in the nucleus accumbens. Scientific Reports. 2022. 12. 1
  • Sehyung Lee, Hideaki Kume, Hidetoshi Urakubo, Haruo Kasai, Shin Ishii. Tri-view two-photon microscopic image registration and deblurring with convolutional neural networks. Neural Networks. 2022. 152. 57-69
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MISC (85)：
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Lectures and oral presentations  (22)：
  • Mechanical Synaptic transmission revealed by optogenetics and optochemistry
    (Keynote Lecture, Optogenetics Gordon Research Seminar, Lucca Italy. 2024)
  • Mechanical brain: The force of synapses on the dendritic spines for memory and cognitive function
    (Special lecture, 101th Annual Meeting of Physiological Society of Japan (Fukuoka, Japan). 2024)
  • Mechanical synaptic transmission: A frontier in neuroscience
    (The Augustine Symposium (NTU, Singapore). 2023)
  • The force of dendritic-spine enlargement facilitating presynaptic exocytosis
    (Excitatory Synapses and Brain Function Gordon Research Conference (Les Diablerets, Switzerland). 2023)
  • Mechanical brain: The force of dendritic-spine synapses for memory and cognition
    (The Laboratory of Molecular Biology seminar series, Cambridge University (Cambridge, UK). 2023)
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Professional career (1)：
  • 医学博士
Work history (7)：
  • 2023/04 - 現在 International Research Institute of Neurointelligence Kasai Lab Professor
  • 2005/10 - 2022/03 東京大学 医学系研究科・大学院 教授
  • 1999/12 - 2005/09 National Institute for Physiological Sciences
  • 1993/11 - 1998/11 The University of Tokyo Graduate School of Medicine
  • 1990/06 - 1993/10 The University of Tokyo Faculty of Medicine
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Awards (5)：
  • 2023/06 - The Government of Japan Japan Academy Prize, Imperial Prize
  • 2018/04 - Medal with Purple Ribbon
  • 2016/11 - 日本医師会 医学賞
  • 2010/12 - 上原記念生命科学財団 上原賞
  • 2002/10 - ブレインサイエンス財団 塚原仲晃記念賞
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