Mitsui Shinichi

Affiliation and department：
Job title：教授
Homepage URL (1)： http://mitsuilab.health.gunma-u.ac.jp/

Research field (5)： Animals: biochemistry, physiology, behavioral science , Neuroscience - general , Psychiatry , Anatomy , Fetal medicine/Pediatrics

Research keywords (32)：神経科学 , プロテアーゼ , 脳神経疾患 , 包括脳ネットワーク , axotomy , facial nerve , regeneration , GAP-43 , プロテオリシス , FRET , 選択的スプライシング , 社会行動 , 脊髄 , spinesin (TMPRSS5) , 学習 , neurotrypsin , Spinesin(TMPRSS5) , plasminogen , tissue plasminogen activator , ノックアウトマウス , KLK11 , Motopsin , Hippostasin , 発達障害 , 海馬 , 精神遅滞 , KLK6 , 運動神経 , PRSS12 , Neurosin , motopsin(PRSS12) , セリンプロテアーゼ

Research theme for competitive and other funds (12)：

2022 - 2025 オキシトシンを介した社会的な高次脳機能制御に関わるニューロンの形態学的解析
2017 - 2020 異性間の絆の神経基盤に基づいたPTSDの治療・予防戦略の構築
2014 - 2017 Metabolite Profiling of Autism Spectrum Disorders (ASD)
2014 - 2016 PTSDによる異性間の絆形成障害の脳内機構の解明
2011 - 2013 抗社会行動を伴う発達障害の分子機構を通じた診断・治療法開発戦略の創成

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Papers (41)：

Shiori Miyata, Masayuki Tsuda, Shinichi Mitsui. Overexpression of Motopsin, an Extracellular Serine Protease Related to Intellectual Disability, Promotes Adult Neurogenesis and Neuronal Responsiveness in the Dentate Gyrus. Molecular neurobiology. 2023
Chiharu Hidaka, Shinichi Mitsui, Yoij Osako, Kou Takahashi, Kenjiro Tanaka, Kazunari Yuri. Differential brain expression pattern of Sez6 alternative splicing isoform with deleted transmembrane domain. Biochemical and Biophysical Research Communications. 2022. 636. 128-132
Ryuji Owada, Yohei Kakuta, Kosuke Yoshida, Shinichi Mitsui, Kazuhiro Nakamura. Conditioned medium from BV2 microglial cells having polyleucine specifically alters startle response in mice. Scientific Reports. 2022. 12. 1
Takahiro Okuda, Yoji Osako, Chiharu Hidaka, Makoto Nishihara, Larry J Young, Shinichi Mitsui, Kazunari Yuri. Separation from a bonded partner alters neural response to inflammatory pain in monogamous rodents. Behavioural brain research. 2022. 418. 113650-113650
Ryuji Owada, Shinichi Mitsui, Kazuhiro Nakamura. Exogenous polyserine and polyleucine are toxic to recipient cells. Scientific Reports. 2022. 12. 1

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MISC (9)：

三井真一. 脳内プロテオリシスの破綻による精神発達障害の発症機構. The Kitakanto medical journal. 2012. 62. 3. 359-359
Shinichi Mitsui, Kazunari Yuri. The modulation of neuronal morphology by the interaction between a mental retardation gene, motopsin/neurotrypsin, and seizure related gene (Sez)-6. NEUROSCIENCE RESEARCH. 2011. 71. E76-E76
三井真一, 大迫洋治, 由利和也. PII-01 脳内プロテアーゼmotopsin/neurotrypsin欠損マウスに見られるCREBリン酸化と行動の異常(神経2,ポスター2,第50回日本組織細胞化学会総会・学術集会). 日本組織細胞化学会総会プログラムおよび抄録集. 2009. 50. 88-88
Shinichi Mitsui, Kiyomi Adachi, Kazunari Yuri. Integral membrane protein 2a interacts with motopsin/prss 12, a serine protease related to mental retardation. NEUROSCIENCE RESEARCH. 2008. 61. S131-S131
Shinichi Mitsui, Yoji Osako, Kazunari Yuri, Fumiaki Yokoi, D. Deng Mai, Li Yuqing, Nozomi Yamaguchi. Mice lacking motopsin/PRSS12 gene showed abnormal social behavior. NEUROSCIENCE RESEARCH. 2007. 58. S64-S64

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Professional career (2)：

Ph.D.
博士(医学) (京都府立医科大学)

Work history (6)：

2011 - 現在 Gunma University Graduate School of Health Science Professor
2009 - 2011 Kochi University
2007 - 2008 Kochi University Medical School
2006 - 2007 Kochi University Medical School
2003 - 2004 Kochi Medical School

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