2019 - 2022 Established epigenetic treatment for chemotherapy-resistant metastatic bladder cancer
2019 - 2022 Integrated genetic and epigenetic analysis of cancer-related genes in non-ampullary duodenal adenomas and intramucosal adenocarcinomas
2019 - 2022 Analysis of anti-tumor mechanism underlying inhibition of a histone methyltransferase DOT1L
2018 - 2022 Elucidation of the function of the Glymphatic system in the human central nervous system
2018 - 2021 Comprehensive analysis of epigenetic alteration and lncRNA involved to colon cancer development
2018 - 2021 Development of personalized medcicine for inflammatory bowel disease based on control of epigenome
2016 - 2019 Molecular analysis of traditional serrated adenoma as a candidate precursor of alternative serrated pathway
2016 - 2019 Elucidating the mechanism of construction of intratumor heterogeneity by tumor-associated glycan
2016 - 2018 The Mechanism of Gemcitabine and Cisplatin resistance in bladder cancer cells.
2016 - 2018 Epigenetic dysregulation of noncoding RNAs in gastrointestinal cancer progression
2015 - 2018 Analysis of molecular mechanism underlying de novo colorectal tumorigenesis pathway
2015 - 2017 Elucidation of molecular pathology and development of diagnostic and therapeutic methods in poorly differentiated colorectal adenocarcinoma by integrated genome and epigenome analysis
2015 - 2017 Development of a sensitive epigenomic biomarker for urothelial cancer
2013 - 2017 Epigenetic mechanisms of valproate-induced polycystic ovary syndrome in epilepsy patients
2013 - 2017 Detection of novel gene mutation causing chromosomal instability using whole exome sequencing in colorectal cancer
2013 - 2016 Identification and analysis of tumor-associated genes of melanoma by functional assay
2010 - 2016 Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
2011 - 2014 Development of novel gastrointestinal cancer diagnostic system based on large epige-nome analysis.
2011 - 2013 Analysis of epigenome and functional RNA in colorectal cancer cells and cancer stem cells
2011 - 2013 Analysis of the abnormalities of microRNA and epigenome and the clinical application in gastroenterological cancers
2011 - 2012 Epigenomic analysis of gastrointestinal cancer stroma
2009 - 2010 Epigenomic analysis of gastrointestinal cancer cells
2008 - 2010 Analysis and risk assessment of diffuse gastric cancer based on inflammation-induced epigenetic alterations
2005 - 2009 Molecular mechanisms of epigenetic alterations in gastrointestinal cancer and application to diagnosis and therapy
2007 - 2008 Development of a novel method for epigenome analysis and application to cancer diagnosis and order made therapy
2005 - 2007 癌関連遺伝子のエピジェネティックな不活化の分子病態解明
2005 - 2006 消化器癌におけるWntシグナルネットワーク破綻の評価システムの構築
2005 - 2006 Tailor-made therapy of gastrointestinal cancer targeting aberrant modification of biological molecules
2000 - 2002 消化器癌におけるメチル化を指標とした治療法の開発
癌エピジェネティクス
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Papers (332)：
Hironori Aoki, Akira Takasawa, Eiichiro Yamamoto, Takeshi Niinuma, Hiro-O Yamano, Taku Harada, Toshiyuki Kubo, Akira Yorozu, Hiroshi Kitajima, Kazuya Ishiguro, et al. Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas. BMC gastroenterology. 2024. 24. 1. 91-91
Nami Nishikiori, Kohichi Takada, Tatsuya Sato, Sho Miyamoto, Megumi Watanabe, Yui Hirakawa, Shohei Sekiguchi, Masato Furuhashi, Akira Yorozu, Kenichi Takano, et al. Physical Properties and Cellular Metabolic Characteristics of 3D Spheroids Are Possible Definitive Indices for the Biological Nature of Cancer-Associated Fibroblasts. Cells. 2023. 12. 17
Hiroshi Kitajima, Reo Maruyama, Takeshi Niinuma, Eiichiro Yamamoto, Akira Takasawa, Kumi Takasawa, Kazuya Ishiguro, Akihiro Tsuyada, Ryo Suzuki, Gota Sudo, et al. TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells. Cell Death & Disease. 2023. 14. 7
Joo Mi Yi, Tae-Hong Kang, Yu Kyeong Han, Ha Young Park, Ju Hwan Yang, Jin-Han Bae, Jung-Soo Suh, Tae-Jin Kim, Joong-Gook Kim, Yan-Hong Cui, et al. Human Neuralized is a novel tumour suppressor targeting Wnt/β-catenin signalling in colon cancer. EMBO reports. 2023. e56335
Yosuke Matsushita, Masato Komatsu, Kazuma Kiyotani, Takeshi Niinuma, Hiromu Suzuki, Tetsuro Yoshimaru, Atsushi Tajima, Issei Imoto, Junko Honda, Yoichi Furukawa, et al. Epigenetic alteration of SALL3 contributes to chemoresistance in triple-negative breast cancer. CANCER SCIENCE. 2022. 113. 752-752
Shohei Sekiguchi, Akira Yorozu, Eiichiro Yamamoto, Takeshi Niinuma, Akira Takasawa, Gota Sudo, Kazushige Koike, Yui Hatanaka, Ayano Yoshido, Hiroshi Kitajima, et al. Analysis of AEBP1 in the microenvironment of head and neck squamous cell carcinoma. CANCER SCIENCE. 2022. 113. 1506-1506
Hideaki Takahashi, Chiaki Okuse, Norie Yamada, Takeshi Niinuma, Masahiro Kai, Hideki Wakasugi, Noriyuki Akutsu, Hiroshi Yotsuyanagi, Michihiro Suzuki, Hiromu Suzuki, et al. LOW EXPRESSION OF miRNA-199-5p AND miRNA-374 CAN PREDICT THE INCIDENCE OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CHRONIC HEPATITIS B AFTER ADMINISTRATION OF NUCLEOSIDE ANALOG. HEPATOLOGY. 2021. 74. 656A-657A
2012/08 - 現在 Sapporo Medical University School of Medicine, Department of Molecular Biorogy
2011/07 - 2012/07 Sapporo Medical University School of Medicine, Department of Molecular Biorogy
2007/04 - 2011/06 Sapporo Medical University
2004/04 - 2007/03 Sapporo Medical University School of Medicine, Dept.of Public Health
2000/05 - 2003/11 Johns Hopkins University Oncology Center Postdoctoral fellow
Awards (9)：
2017 - 日本消化器癌発生学会 田原榮一賞
2016 - 北海道医師会賞・北海道知事賞
2014 - 北海道科学技術奨励賞
2008 - 第19回日本消化器癌発生学会総会最優秀賞
2005 - 日本医師会医学研究助成
2005 - 消化管分子機構研究会優秀演題
2005 - 日本臨床分子医学会学術奨励賞
2004 - 日本分子腫瘍マーカー研究会 学術奨励賞
2004 - 日本癌学会奨励賞
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Association Membership(s) (16)：
American Association for Cancer Reserach
, JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY
, 日本消化器癌発生学会
, 日本エピジェネティクス研究会
, がん分子標的治療研究会
, 日本分子腫瘍マーカー研究会
, 日本分子生物学会
, 日本消化器病学会
, 日本内科学会
, 日本癌学会
, The Japanese Association for Molecular Target Therapy of Cancer
, Japan Society for Molecular Tumor Marker Research
, The Molecular Biology Society of Japan
, The Japanese Society of Gastroenterology
, The Japanese Society of Internal Medicine
, Japanese Cancer Association
