Shioda Seiji

2020 - 2023 Elucidation of neuroprotection and neural axon regeneration mechanism by PACAP

2020 - 2023 Development and clinical application of drugs for prevention and treatment of dry eye

2018 - 2021 Study on metabolic network between organs via peripheral GALP

2018 - 2021 Elucidation of corneal epithelial wound healing effect and wound healing mechanism by PACAP

2018 - 2021 Elucidation of the anti-obesity effect of exercise and nasal administration of peptides -from molecular network analysis-

2016 - 2021 Development and clinical application research of new preventive treatment method by neuropeptide PACAP for brain and spinal cord injury.

2017 - 2020 PACAP/PAC1R signaling in astrocytes involves in fear memory formation

2017 - 2020 Multi-omics approach unraveling neonatal mouse brain for DOHaD

2015 - 2019 Analysis of mechanisms of autonomous function between the brainstem and the spinal cord with using a decerebrated and arterially perfused in situ preparation

2014 - 2017 Identification of molecular factors related to PACAP neuroprotective effect in ischemic brain

2014 - 2017 Metabolic analysis of lipid metabolism in the anorexigenic peptide and exercise

2013 - 2017 Relationship between transplanted bone marrow mesenchymal stem/progenitor cells and marrow tissues after spinal cord injury

2013 - 2017 Study of Novel receptors recognizing un-Methylated DNA

2015 - 2017 神経ペプチドによる脊髄損傷治療法の新戦略

2013 - 2016 Evaluation and development of music therapy program exercise for function maintenance with multi-disciplinary collaboration and improvements

2013 - 2016 Repairing mechanism of human mesenchymal stem cells (hMSCs) via immune regulation on ischemia brain injury

2011 - 2016 神経損傷防御の基盤研究とトランスレーショナルリサーチ

2012 - 2015 Effect of PACAP for prevention/treatment of dry eye syndrome

2012 - 2015 later

2012 - 2015 Morphological analysis of afferent neurons of galanin-like peptide (GALP) using transgenic mice expressing retrogradely transpoted tracer under the control of GALP promoter with Cre-loxP system.

2011 - 2015 Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury

2010 - 2015 Molecular basis and disorders of control of appetite and fat accumulation

2013 - 2015 ペプチド・タンパクの点鼻投与による神経疾患の予防・治療法の新戦略

2010 - 2015 摂食・エネルギー代謝調節に関わる摂食調節ペプチドの機能形態学的解析

2011 - 2013 Monitoring of neuroinflammation and creation of new strategy after spinal cord injury.

2011 - 2013 Ontogenic analysis of the PACAP receptor, PAC1R, in mouse major salivary glands

2011 - 2013 Elucidating molecular basis of adult disease development by examining fetal tissues

2011 - 2013 A new strategy to conquer obesity by use of a newly discovered intranasal infusion of anorexigenic peptide and exercise

2010 - 2012 Effect of prenatal environment on stress response in offspring

2010 - 2011 Mechanism of PACAP-induced tear secretion

2010 - 2011 The scavengering effect of edaravone to nitric monoxide in mice traumatic brain injury

2009 - 2011 Establishment of human bone marrow mesenchymal stem cells(hMSCs) culture with serum free medium and evaluation of spinal cord regeneration

2009 - 2011 Effect of PACAP on adult retinal stem cell and the regenerative potential.

2009 - 2011 Histone modification in a rat fetal brain an neuronal network formation in a rat neonate after prenatal valproic acid treatment.

2009 - 2011 Testis-specific production and its physiological significance of PACAP

2009 - 2011 Analysis of crosstalk between the central nervous system and peripheral organs involving galanin-like peptide(GALP)

2009 - 2011 PKCdelta molecules specifically expressed in testis

2009 - 2011 Neuroendocrine control of feeding behavior by neuropeptides in fish and its evolutionary modeling

2009 - 2011 新規神経ペプチドGALPによる肥満克服の新戦略

2008 - 2010 Effect of PACAP on saliva secretion.

2008 - 2010 The roles and the kinetics of gp91 phox after traumatic brain injury in mice

2008 - 2010 Studies on the neutrophil-mediated transport of Shiga toxins

2008 - 2010 Basic research on metabolic syndrome improvement by anti-obesity peptide administering and therapeutic exercise

2008 - 2010 PACAPによる神経細胞死防御機構の解明と神経再生の分子基盤

2007 - 2008 The Research of Oxidative stress and Free radical production in brain injury

2007 - 2008 Analysis of neuronal feeding-regulating circuits involving ghrelin using the transgenic mice

2007 - 2008 遺伝子工学を用いた脳内摂食調節ニューロンネットワーク解析法の開発

2006 - 2008 Molecular basis on function and clinical implication of neuropeptide PACAP

2006 - 2007 The roles and the kinetics of gp91 phox after traumatic brain injury in mice

2006 - 2007 Morphofimctional analysis ofGalanin-lice Peptide on regulation offeeding and enegy metabolism

2005 - 2006 Free Radical Monitoring of Brain Injury and their Basic Studies

2005 - 2006 A new approach for the detection of developmental neurotoxicity induced by prenatal chemical exposure and an analysis of the critical period for the induction of neurodevelopmental disorders.

2005 - 2006 Analysis of neuropeptide PACAP receptor positive stromal cells in thymus

2003 - 2006 The establishment of methods for reproduction of functional teeth by use of long-term culture

2004 - 2005 Developments of free radical monitoring and treatment in neuro-emergency diseases

2004 - 2005 Functional analysis of Galanin-like peptide (GALP) in feeding regulation

2003 - 2005 Molecular pharmacological aspects of the neuropeptide PACAP in brain and pancreas

2004 - 2004 新しい医学教育における解剖学教育に関する調査研究

2003 - 2004 腸管上皮細胞増殖・組織再生因子としてのグレリン

2002 - 2004 PACAPによる脳虚血障害保護機構

2002 - 2003 Synaptic regulation of ghrelin neurons on feeding-regulating neurons and its signal transduction

2002 - 2003 Studies on significance of accumulation of ubiquitin-protein conjugates with respect to cell damage and death induced by brain ischemia.

2000 - 2002 Involvement in neurodegeneration and cell death of synuclein family protein

2000 - 2002 Regulation by glucose and insulin of the neurons in feeding-regulatory centers and its alteration in obesity and diabetes

2000 - 2001 orexinergi innervatiom of feeding-regulating neurons and signal transduction mechanism

1999 - 2001 Study on the physiological function of synuclein family

1999 - 2001 遺伝子欠損マウスを用いた虚血性網膜神経細胞死におけるTNFαの機能解析

1999 - 2000 神経細胞死におけるサイトカインの機構制御と脳神経外科疾患への臨床応用

1999 - 1999 食欲・代謝中枢の単一ニューロン活動計測と調節因子同定・作用機構解析の実験法の確立

1998 - 1999 覚醒剤・コカイン・PCPによる薬物依存:A10神経を用いた分子細胞生理学的研究

1998 - 1999 PACAP受容体のバソプレシン分泌・合成制御機構

1997 - 1999 SOURCE OF NITRIC OXIDES IN THE BODY DURING AND AFTER ENVIRONMENTAL STRESS

1997 - 1999 遺伝子ターゲティング法を用いたPACAPによる神経細胞死抑制機構の解明

1997 - 1998 Control of glucose metabolism by PACAP : stimulation of insulin secretion and potentiation of insulin action

1997 - 1998 Aminergic and peptidergic innervation of neuroendocrine cells and its signal transduction system

1996 - 1997 神経細胞死抑制因子としてのPACAP

1996 - 1996 In Situ PCR 法によるPACAPレセプターサブタイプの機能形態学的解析

1995 - 1996 Physiological significance of enzyme-activating substances in the neuroendocrine cells.

1995 - 1995 精子細胞の分化・成熟過程におけるPACAPの機能的意義

1990 - 1991 Cytochemical observations of Neuronal Influence on Vasopressin Synthesis and secretion

1990 - 1990 三重免疫電顕法によるTRHニュ-ロンのNPY・カテコ-ルアミン共存性神経支配

1986 - 1987 Synaptic Inputs to Neurosecretory Neurons

1979 - 1979 TRH含有ニューロンの免疫組織化学的研究

neurodevelopment

Central mechanism of feeding regulation

neuronal cell death and its protection

Catecholaminergic innervation of vasopressin neurons

Protection of neuronal cell death by PACAP

Functional morphology of PACAP