Rchr
J-GLOBAL ID：200901062478470987   Update date: Apr. 10, 2024

AKIYAMA Shuji

アキヤマ シュウジ | AKIYAMA Shuji
Affiliation and department：
Institute for Molecular Science

About Institute for Molecular Science


Job title： Professor
Other affiliations (1)：
Homepage URL  (1)： https://groups.ims.ac.jp/organization/akiyama_g/
Research field  (4)： Functional biochemistry ,  Molecular biochemistry ,  Structural biochemistry ,  Biophysics
Research keywords  (9)： Temperature Compensation ,  X-ray Crystallography ,  Protein Folding ,  Small-angle X-ray Scattering ,  Cyanobacteria ,  Circadian Clock ,  KaiC ,  Biological Clock ,  Protein
Research theme for competitive and other funds  (14)：
  • 2022 - 2027 Simplifying complexity and diversity of circadian clocks
  • 2023 - 2026 Time-Dependent Modulation of KaiC-KaiA/KaiB Binding Modes in the Autonomous Oscillation Process of the Kai System
  • 2017 - 2022 An Integrated Multi-scale Approach for Studying Cyanobacterial Circadian Clock System
  • 2017 - 2018 生物時計システムの周期と温度補償制御ロジックの構造化学的解明
  • 2016 - 2018 X線溶液散乱と高速AFMを用いた生物時計因子の動的構造解析
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Papers (67)：
  • Yoshihiko Furuike, Yasuhiro Onoue, Shinji Saito, Toshifumi Mori, Shuji Akiyama. The priming phosphorylation of KaiC is activated by the release of its autokinase autoinhibition. 2024
  • Yoshihiko Furuike, Eiki Yamashita, Shuji Akiyama. Structure-function relationship of KaiC around dawn. Biophysics and Physicobiology. 2024. 21. 1. n/a-n/a
  • Atsushi Mukaiyama, Yoshihiko Furuike, Eiki Yamashita, Shuji Akiyama. Highly sensitive tryptophan fluorescence probe for detecting rhythmic conformational changes of KaiC in the cyanobacterial circadian clock system. The Biochemical journal. 2022. 479. 14. 1505-1515
  • Damien Simon, Atsushi Mukaiyama, Yoshihiko Furuike, Shuji Akiyama. Slow and temperature-compensated autonomous disassembly of KaiB-KaiC complex. Biophysics and physicobiology. 2022. 19. 1-11
  • Yoshihiko Furuike, Atsushi Mukaiyama, Shin-ichi Koda, Damien Simon, Dongyan Ouyang, Kumiko Ito-Miwa, Shinji Saito, Eiki Yamashita, Taeko Nishiwaki-Ohkawa, Kazuki Terauchi, et al. Regulation Mechanisms of the Dual ATPase in KaiC. bioRxiv. 2021
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MISC (29)：
  • 古池美彦, 古池美彦, 向山厚, 向山厚, 欧陽東彦, 伊藤(三輪)久美子, SIMON Damien, SIMON Damien, 山下栄樹, 近藤孝男, et al. 藍藻の概日リズムを制御する時計タンパク質KaiCのアロステリー. 日本結晶学会年会講演要旨集. 2021. 2021
  • OUYANG Dongyan, FURUIKE Yoshihiko, FURUIKE Yoshihiko, MUKAIYAMA Atsushi, MUKAIYAMA Atsushi, ITO-MIWA Kumiko, KONDO Takao, AKIYAMA Shuji, AKIYAMA Shuji. Capability of the ATPase-based Screening System to Search Structural Units Determining the Function of Cyanobacterial Clock Protein KaiC. 時間生物学. 2019. 25. 2
  • FURUIKE Yoshihiko, FURUIKE Yoshihiko, MUKAIYAMA Atsushi, MUKAIYAMA Atsushi, YAMASHITA Eiki, KONDO Takao, AKIYAMA Shuji, AKIYAMA Shuji. Allosteric Regulation Designed in Clock Protein KaiC. 生物物理(Web). 2018. 58. Supplement 1-2
  • MUKAIYAMA Atsushi, MUKAIYAMA Atsushi, FURUIKE Yoshihiko, FURUIKE Yoshihiko, YAMASHITA Eiki, KONDO Takao, AKIYAMA Shuji, AKIYAMA Shuji. Conformational rearrangements of the C1 ring in KaiC measure the timing of assembly with KaiB via a conformational selection mechanism. 生物物理(Web). 2018. 58. Supplement 1-2
  • 秋山 修志, 古池 美彦, 向山 厚. 変化し続ける概日時計のかたち. 時間生物学. 2018. 24. 92-99
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Lectures and oral presentations  (34)：
  • Screening and Characterization of Temperature-dependent Circadian Clock Mutants in Cyanobacteria
    (5th Asian Forum on Chronobiology, Kaifeng, China 2021)
  • Keynote Lecture: Cyanobacterial circadian clock system through the chemistry of rhythm, structure, and evolutionary diversity
    (ELSI 8th International Symposium, Tokyo, Japan 2020)
  • Keynote Lecture: Frontiers of the Intermolecular Interactions Analysis of Biomolecules promoted by BioSAS
    (PF Workshop, Tsukuba, Japan 2019)
  • ATPase-based in vitro Screening for KaiC Clock Mutants in Cyanobacteria
    (XVI Congress of the European Biological Rhythms Society, Lyon, France 2019)
  • Keynote Lecture: Cyanobacterial circadian clock system through the chemistry of rhythm, structure, and evolutionary diversity
    (V World Congress of Chronobiology, Suzhou, China 2019)
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Education (2)：
  • 1997 - 2002 Kyoto University Graduate School of Engineering Department of Molecular Engineering
  • 1993 - 1997 Kyoto University Faculty of Engineering Industrial Chemistry
Professional career (1)：
  • Ph.D. (Kyoto University)
Work history (8)：
  • 2012/04 - 現在 The Graduate University for Advanced Studies School of Physical Sciences Professor
  • 2012/04 - 現在 National Institutes of Natural Sciences Institute for Molecular Science Professor
  • 2011/04 - 2012/03 Nagoya University Graduate School of Science Associate Professor
  • 2008/08 - 2011/03 Nagoya University Graduate School of Science Junior Associate Professor
  • 2005/10 - 2008/07 Japan Science and Technology Agency PRESTO Researcher
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Awards (5)：
  • 2016 - Japan Society for the Promotion of Science JSPS prize
  • 2008 - The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Japan The Young Scientists' Prize
  • 2007 - The Biophysical Society of Japan Young Scientist Prize
  • 2006 - IUCr Commission on Small-angle Scattering 2006 SAS Young Scientist Prize
  • 2002 - The Protein Society Annual Poster Board Award
Association Membership(s) (8)：
JAPAN SOCIETY FOR MOLECULAR SCIENCE ,  THE CHEMICAL SOCIETY OF JAPAN ,  SOCIETY FOR RESEARCH ON BIOLOGICAL RHYTHMS ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  JAPANESE SOCIETY FOR CHRONOBIOLOGY ,  THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY FOR SYNCHROTRON RADIATION RESEARCH
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