Rchr
J-GLOBAL ID:200901062495542274
Update date: Oct. 08, 2024
Seyama Kuniaki
セヤマ クニアキ | Seyama Kuniaki
Affiliation and department:
Job title:
Professor
Research field (4):
Respiratory medicine
, Molecular biology
, Pathobiochemistry
, Genetics
Research keywords (6):
lymphangioleiomyomatosis
, Birt-Hogg-Dube syndrome
, pneumothorax and cystic lung diseases
, Human Genetics
, COPD
, smoking cessation
Research theme for competitive and other funds (24):
- 2020 - 2023 慢性タバコ煙曝露システムを用いた加熱式タバコエアロゾルによる肺傷害の解析
- 2019 - 2022 The role of extracellular vesicles in the pathobiology of lymphangioleiomyomatosis
- 2017 - 2021 Airway secreted exosome as a novel therapeutic target for Chronic Obstructive Pulmonary Disease (COPD)
- 2016 - 2019 Investigation on the endothelial-mesenchymal transition in lymphangioleiomyomatosis
- 2015 - 2018 Application of iPS cell technology to lung regeneration and development of bioresource for elucidating the mechanisms of lung diseases
- 2014 - 2018 MicroRNAs associated with smoking-induced pulmonary emphysema in senescence marker protein-30 knockout mice
- 2013 - 2016 To develop a novel method to establish the diagnosis of BHD syndrome
- 2012 - 2015 Study on the germline FLCN mutations and the mechanism of pulmonary cyst formation in Birt-Hogg-Dube syndrome
- 2010 - 2015 Researches using iPS cells on intractable respiratory diseases to elucidate their pathogenesis and develop novel therapy.
- 2010 - 2011 Study on the germline FLCN mutations and the mechanism of pulmonary cyst formation in Birt-Hogg-Dube syndrome
- 2009 - 2011 Isolation of LAM stem cells and its application for the establishment of mouse LAM model.
- 2007 - 2008 Elucidation of the mechanism for cell adhesion between LAM cells and lymphatic endothelial cells in the LAM cell clusters
- 2006 - 2008 Study on the mechanism of LAM cell proliferation and disease progression in lymphangioleiomyomatosis
- 2006 - 2007 多発性嚢胞性肺疾患におけるBHD遺伝子解析-嚢胞形成の分子病因的検討-
- 2004 - 2005 Mechanisms of proliferation and metastasis of LAM cells in lymphangioleiomyomatosis (LAM)
- 2003 - 2004 Analysis of airway inflammation and remodeling induced by chronic cigarette smoke exposure in mice lungs.
- 2002 - 2003 Comprehensive analysis of pathogenesis in lymphangioleiomyomatosis
- 2001 - 2002 Cigarette smoke-induced lung pathology in SMP30 knockout mice
- 2000 - 2001 レトロウイルス調節遺伝子bel geneを用いた肺線維症実験モデル動物の作製
- 2000 - 2000 アジアにおける肺気腫およびα1アンチトリプシン欠損型亜型Siiyamaの疫学調査
- 1999 - 2000 Molecular and genetic studies on patho genesis and patho plrysiolegy of emphysema
- 1991 - 1992 Analysis of cystic fibrosis transmembrane conductance regulator gene in patients with diffuse panbronchiolitis.
- 1991 - 1991 白血球エラスターゼ遺伝子異常に基づく機能的欠陥機序による肺気腫発症の解析
- 1989 - 1990 Direct Search for Nucleotide Substitutions Responsible for Defects of Alpha 1-Antitrypsin Molecules in Patients with Pulmonary Emphysema.
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Papers (383):
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Tomoko Yamada, Koji Sugano, Kei Matsuno, Saori Hotta, Nana Ayame, Honami Sugitani, Makoto Mihara, Hisako Hara, Kazuhisa Takahashi, Kuniaki Seyama. A 53-year-old Man with Idiopathic Bilateral Chylothorax Refractory to Lymphaticovenular Anastomosis: A Case Report. Internal medicine (Tokyo, Japan). 2024
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Kuniaki Seyama, Etsuko Komiyama, Hitoshi Tsuchihashi, Makiko K Okura, Yasuhito Sekimoto, Yoichiro Mitsuishi. Stepwise Incremental Dose Schedule of Sirolimus Is Successfully Tolerated by a Patient With Lymphangioleiomyomatosis Who Was Initially Allergic to mTOR Inhibitors. Cureus. 2024
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Masahiro Torasawa, Takehito Shukuya, Kohei Uemura, Takuo Hayashi, Toshihide Ueno, Shinji Kohsaka, Yoshihiro Masui, Yukina Shirai, Makiko Okura, Tetsuhiko Asao, et al. Lymphangioleiomyomatosis as a potent lung cancer risk factor: Insights from a Japanese large cohort study. Respirology (Carlton, Vic.). 2024
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Yasuhito Sekimoto, Isao Yamawaki, Chikako Iwabuchi, Koichi Nishino, Kazuhisa Takahashi, Kuniaki Seyama. An elderly woman with Birt-Hogg-Dubé syndrome having multiple pulmonary cysts mimicking lymphangioleiomyomatosis. Respiratory investigation. 2024. 62. 3. 462-464
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Koichi Nishino, Tatsuya Takagi, Takuo Hayashi, Shinya Kunimine, Hitoshi Tsuchihashi, Shunsuke Kato, Kazuhisa Takahashi, Kuniaki Seyama. Pulmonary Erdheim-Chester Disease With BRAF-AGAP3 Fusion: Late-Onset Osteolytic Femoral Lesions Despite Long-Term Pulmonary Stabilization With Corticosteroid. Cureus. 2024. 16. 3. e55670
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MISC (519):
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齋田瑞恵, YAN Yan, 瀬山邦明, 伊藤佳奈美, 笹野央, 内藤俊夫. COVID19ワクチンの副反応の調査. 日本病院総合診療医学会雑誌(Web). 2021. 17
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荒井雄太, 阿部瞳, 永田祐一, 関本康人, 宿谷威仁, 瀬山邦明, 高橋和久. 間質性肺炎の治療中にCapnocytophaga gingivalisによる肺化膿症を発症した1例. 日本内科学会関東支部関東地方会. 2021. 668th
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山田朋子, 松野圭, 金丸良太, 嶋村尚子, 菅野康二, 瀬山邦明, 原尚子, 三原誠, 高橋和久. A case of adult idiopathic chylothorax. 日本呼吸器学会誌(Web). 2020. 9
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本多紘二郎, 滝澤始, 齋藤佑一, 小林欣夫, 久志本成樹, 野々山恵章, 新田(荒野)直子, 瀬山邦明, 小竹徹, 白井小百合, et al. 検査値を読む 2020 17章 炎症マーカー検査. 内科. 2020. 125. 4. 808-809
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虎澤匡洋, 虎澤匡洋, 朝尾哲彦, 宿谷威仁, 関本康人, 西野宏一, 岡本翔一, 高遼, 嶋田奈緒子, 高橋和久, et al. Clinical analysis of lymphangioleiomyomatosis complicated with lung cancer. 日本呼吸器学会誌(Web). 2020. 9
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Books (15):
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第3章 胸膜・縦隔・胸壁・横隔膜疾患(胸膜疾患; 胸水、気胸・緊張性気胸)(新臨床内科学10版)
矢崎義雄 監修(医学書院) 2020
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Chapter 16. Pleural disease in Diffuse Cystic Lung Diseases (In Cystic Lung Diseases. Cancer and lymphatic metastasis)
Gupta, Nishant (Springer Nature) 2020
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呼吸器疾患 まれな肺疾患 リンパ脈管筋腫症/α1-アンチトリプシン欠乏症(内科学書 改訂第9版)
南学正臣総編集(中山書店) 2019
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4. 症候学 4-27 胸水/9.9 嚢胞および拡張性気管支・肺疾患 9-1)嚢胞性肺疾患 9-2)気管支拡張症(内科学第11版)
矢崎義雄 総編集(朝倉書店) 2017
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2.症候学 2-27 胸水/7.9 嚢胞および拡張性気管支・肺疾患 9-1)肺嚢胞症 9-2)気管支拡張症 (内科学第10版)
矢崎義雄総編集(朝倉書店) 2013
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Education (2):
- 1882 - 1986 Hokkaido University Graduate School of Medicine
- 1976 - 1982 Hokkaido University School of Medicine
Professional career (2):
- (BLANK) (Hokkaido University)
- 医学博士 (北海道大学)
Work history (7):
- 2022/04 - 現在 Juntendo University
- 2021/03 - 2022/03 Juntendo University
- 2007/04 - 2021/02 Juntendo University
- 2006/02 - 2007/03 Juntendo University Associate Professor
- 1999/04 - 2006/01 Juntendo University
- 1995/03 - 1998/03 The University of Washington Department of Pediatrics Visiting Scientist
- 1990 - 1995 Juntendo University
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Committee career (2):
- - 現在 日本呼吸器学会 禁煙推進委員会
- - 現在 日本気胸・嚢胞性肺疾患学会 理事
Awards (3):
- 2016 - LAM Foundation Established Investigator Award
- 2012/04 - 日本呼吸器学会 熊谷賞
- 2012/03 - LAM Foundation A Breath of Hope 2012 Scientific Advancement Award
Association Membership(s) (6):
日本気胸・嚢胞性肺疾患学会
, 日本人類遺伝学会
, アジア太平洋呼吸器学会(Asian Pacific Society of Respirology)
, 日本内科学会
, 日本肺癌学会
, 日本呼吸器学会
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