Rchr

J-GLOBAL ID：200901062517672266 Update date: Jun. 06, 2020

Sasaki Yusuke

ササキユウスケ | Sasaki Yusuke

Affiliation and department：

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (2)：ペプチド化学 , Peptide Chemistry

Research theme for competitive and other funds (2)：

オピオイドペプチド類の構造と活性の関係
Structure-Activity Relationships of Opioid Peptides

MISC (64)：

Y Jinsmaa, A Miyazaki, Y Fujita, TY Li, Y Fujisawa, K Shiotani, Y Tsuda, T Yokoi, A Ambo, Y Sasaki, et al. Oral bioavailability of a new class of mu-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH2)(n)]2(1H)-pyrazinone with central-mediated analgesia. JOURNAL OF MEDICINAL CHEMISTRY. 2004. 47. 10. 2599-2610
Y Jinsmaa, Y Okada, Y Tsuda, K Shiotani, Y Sasaki, A Ambo, SD Bryant, LH Lazarus. Novel 2 ', 6 '-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2004. 309. 1. 432-438
2',6'-Dimethylphenylalanine(Dmp)can mimic the N-terminal Tyr in opioid peptides. Biological and Pharmaceutical Bulletin. 2004. 27, 244-247
A Ambo, H Niizuma, A Sasaki, H Kohara, Y Sasaki. Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2003. 13. 7. 1269-1272
A Ambo, H Niizuma, A Sasaki, H Kohara, Y Sasaki. Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2003. 13. 7. 1269-1272

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Books (2)：

New生化学(共著)
廣川書店 1992
New Biochemistry
1992

Works (6)：

Dmp含有オピオイドペプチドの研究
1998 -
Studies on opioid peptides containing Dmp residue
1998 -
ダイノルフィンフラグメントによる抗痴呆薬の開発研究
1995 - 1997
Studies on development of antiamnesic drugs based on dynorphin fragments
1995 - 1997
鎮痛活性デルモルフィンペプチドの研究
1984 - 1992

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Education (4)：

- 1975 東北薬科大学薬学研究科生化学
- 1975 Tohoku Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences
- 1970 東北薬科大学薬学部薬学科
- 1970 Tohoku Pharmaceutical University Faculty of Pharmaceutical Science

Professional career (1)：

(BLANK) (Tohoku Pharmaceutical University)

Work history (6)：

1989 - 1995 東北薬科大学助教授
1989 - 1995 Tohoku Pharmaceutical University, Assistant Professor
1980 - 1989 東北薬科大学講師
1980 - 1989 Tohoku Pharmaceutical University, Lecturer
1975 - 1980 東北薬科大学助手

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Awards (1)：

1987 - 日本薬学会東北支部奨励賞

Association Membership(s) (4)：

日本生化学会 , 米国ペプチド学会(American Peptide Society) , 日本ペプチド学会 , 日本薬学会

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